CAS: 528-90-5; 2,4,5-Trimethylbenzoic Acid

上下游产品

CAS号95-93-2 1,2,4,5-四甲苯 | CAS号109-72-8 正丁基锂 | CAS号5469-19-2 5-溴-1,2,4-三甲基苯 | CAS号590-93-2 2-丁炔酸 | CAS号513-81-5 2,3-二甲基-1,3-丁二烯 | CAS号64-19-7 冰醋酸 | CAS号124-38-9 二氧化碳 | CAS号3453-84-7 苯磺酸 | CAS号2040-07-5 2',4',5'-三甲基苯乙酮 | CAS号58260-83-6 2,4,5-三甲基苯甲腈 | CAS号6051-66-7 2,5-二甲基对苯二甲酸 | CAS号2790-09-2 4,6-二甲基间苯二甲酸 | CAS号89-05-4 均苯四甲酸 | CAS号4380-67-0 2,4,5-trimethyl...

📜1,2,4,5-四甲苯置于bismuth(Lll) Trifluoromethanesulfonate,2-吡啶甲酸,叔丁基过氧化氢体系中,用 吡啶,水,溶剂黄146 作为反应溶剂,化学反应 20.0H,以72%的收率获得产物2,4,5-三甲基苯甲酸
参考文献:叔丁基氢过氧化铋催化的苄基氧化反应.
标题:叔丁基氢过氧化铋催化的苄基氧化反应.
摘要:[反应:见正文]在吡啶和乙酸中,铋和吡啶甲酸在叔丁基过氧化氢催化下用叔丁基氢过氧化物氧化烷基和环烷基芳烃,得到相应的苄基酮(48-99%).或者,甲基芳烃的氧化得到相应的取代的苯甲酸(50-95%).初期机理研究与激进机理一致,而不是与铋(iii)-铋(v)循环一致.
DOI:10.1021/ol051765K

专利信息

专利号:US-4767853-A
优先权日:1986-07-21
标题:Synthesis of 1-(allyloxycarbonyl)-methyl-3-(hydroxyethyl)-4-beta-naphthoxythiocarbonylthio-2-azetidinones and hydroxy protected analogs thereof
发明人：HOU DONALD
权利人:SCHERING CORP
摘要:A process for producing a compound having the formula wherein Pr is hydrogen or a hydroxy protecting group and Pr<1> is a carboxy protecting group, comprising reacting a compound of the formula wherein Pr is as previously defined, with a compound having the formula Pr<1>-OH, wherein Pr<1> is as previously defined and either mineral acid or a silver salt of an organic base, and reacting the product so produced with a compound having the formula: wherein L is a leaving group. Three reaction schemes are disclosed as well as novel intermediate compounds.

专利号:US-4876338-A
优先权日:1986-07-21
标题:Synthesis of azetidinones using CuCl
发明人：HOU DONALD; WONG YEE-SHING; GALA DINESH; STEINMAN MARTIN
权利人:SCHERING CORP
摘要:A multi-step stereospecific process for preparing (3S,4R,5R)-1-(allyloxycarbonyl)-methyl-3-(1-hydroxyethyl)-4-beta-naphthoxythi ocarbonylthio-2-azetidinone, stereoisomers thereof or hydroxy protected analogs thereof from anhydropenicillin. The azetidinones are intermediates useful for producing penems which are a known group or antibacterial compounds. The process involves protecting the hydroxy group of anhydropenicillin with a readily removable hydroxy protecting group, then reacting the resulting compound by treatment with oxygen and cuprous chloride in methanol, followed by reaction with ozone to produce a hydroxy protected dithiobis azetidinone and convert the methylidene groups originally in the 2-position of anhydropenicillin and in the bis-compound, to a (methoxycarbonyl)-carbonyl group. The resulting compound is converted to the unprotected dithiobis compound by reaction with ammonium hydroxide, then allyliodoacetate followed by an acid. Reaction of the resulting compound with zinc and a mineral acid followed by reaction with 0-2-naphthalenylcarbonochloridothioate converts the unprotected dithiobis compound to 1-(allyloxycarbonyl)methyl-3-(1-hydroxyethyl)-4-beta-naphthoxy (thiocarbonyl)thio-2-azetidinone.

专利号:US-9452425-B2
优先权日:2002-09-26
标 题 :Compositions containing ionic liquids and their uses, in particular in organic synthesis
发明人：VAULTIER MICHEL; GMOUH SAID
权利人:VAULTIER MICHEL; GMOUH SAID; CENTRE NAT RECH SCIENT; UNIV RENNES
摘要:An ionic liquid is used as liquid matrix for organic synthesis in homogeneous phase on soluble support, the ionic liquid being presented in liquid or solid form at ambient temperature, of formula A 1 + X 1 − , A 1 + representing a cation, functional or non-functional, or a mixture of cations in which either none of the cations is functional or at least one of the cations is functional, and X 1 − an anion, functional or non-functional, or a mixture of anions in which either none of the anions is functional or at least one of the anions is functional.

专利号:US-6350429-B1
优先权日:1997-09-29
标 题 :Method for making molecular sieves and novel molecular sieve compositions
发明人：MURRELL LAWRENCE L; OVERBEEK RUDOLF A; CHANG YUN-FENG; VAN DER PUIL NELLEKE; YEH CHUEN Y
权利人:ABB LUMMUS GLOBAL INC
摘要:This invention relates to the synthesis of large pore composite molecular sieves and to the synthetic large pore composite molecular sieves so produced. The molecular sieves of the invention have the same general utilities of the comparable molecular sieves of the prior art but have been found to be superior catalysts and absorbents. This invention relates to a hydrothermal synthesis of large pore molecular sieves from nutrients, at least one of which contains an amorphous framework-structure, and which framework-structure is essentially retained in the synthetic molecular sieve. This invention stems from a discovery that the intrinsic porosity characteristics of a nutrient that possesses an amorphous cation oxide-framework can be substantially retained in the final molecular sieve containing product formed by a hydrothermal process by carefully controlling the conditions under which the hydrothermal process is conducted. For example, the invention contemplates retention of the particle size in a final molecular sieve-containing product that corresponds with that of an amorphous cation oxide-framework nutrient used in its manufacture. This invention drives the selection of process conditions to achieve one or more of macro and meso porosity ('large pore composite porosity') in the final molecular sieve product as a direct product of the hydrothermal reaction producing the molecular sieve. The invention allows the production of a molecular sieve that is in situ incorporated in the framework morphology of a solid cation oxide-framework used in the molecular sieve's manufacture.

专利号:US-9777013-B2
优先权日:2013-08-14
标题 :Derivatives of uncialamycin, methods of synthesis and their use as antitumor agents
发明人：NICOLAOU KYRIACOS C; LU MIN; MANDAL DEBASHIS; GANGWAR SANJEEV; CHOWDARI NAIDU S; POUDEL YAM B
权利人:UNIV RICE WILLIAM M; BRISTOL MYERS SQUIBB CO; SCRIPPS RESEARCH INST
摘要:In one aspect, the present disclosure provides new analogs of uncialamycin of formulae (I) and (II). The present disclosure also provides novel synthetic pathways to obtaining uncialamycin and analogs thereof. Additionally, the present disclosure also describes methods of use of uncialamycin and analogs thereof. In another aspect, the present disclosure provides antibody-drug conjugates comprising the compounds of formulae (I) and (II).

专利号:US-12024521-B2
优先权日:2020-06-30
标 题:Isoquinoline derivatives, methods of synthesis and uses thereof
发明人：Paulvannan Kumarapandian; SOLAS DENNIS; KITAYGORODSKYY ANATOLIY; LINGAPPA VISHWANATH R
权利人:PROSETTA BIOSCIENCES INC
摘要:Described herein are compounds, pharmaceutical compositions and methods of using these compounds and pharmaceutical compositions for treating and/or preventing conditions such as amyotrophic lateral sclerosis. These compounds and pharmaceutical compositions are also useful as antivirals and antimicrobial agents.