专利号:US-12281398-B2 优先权日:2022-02-07 标题:Microfluidic process for the general electrochemical synthesis of geminal dipseudohalide or halide-pseudohalide compounds 发明人:SCHROER THORSTEN G; LECROY GREGORY E; AGUILA MIGUEL; RODRIGUEZ MAYRA P; DOWNARD TYLER J; MACLEOD BRIANNA L 权利人:US GOV AIR FORCE; US AIR FORCE 摘要:A process for the microfluidic electrochemical synthesis of geminal dipseudohalide or halide-pseudohalide compounds comprising the steps ofpumping a solution comprising a compound of Formula Iinto a microfluidic electrochemical reactor in the presence of a base, one of a halide or pseudohalide salt (MY), and a mediator;applying an electrical current through the microfluidic electrochemical reactor; andperforming oxidative addition to create a geminal dipseudohalide or halide-pseudohalide compound of the general Formula II
专利号:US-6765114-B1 优先权日:1998-12-29 标题 :Process for the synthesis of 1-(aminomethyl)cyclohexyl-acetic acid 发明人:GIZUR TIBOR; LENGYEL ZOLTANNE; SZALAI KRISZTINA 权利人:RICHTER GEDEON VEGYESZET 摘要:The invention relates to a new process for the synthesis of 1-(aminomethyl)cyclohexyl-acetic acid of formula (I) via the new intermedier 1-(nitromethyl)cyclohexyl-acetic acid derivative of formula (II), wherein R represents hydrogen, benzyl group, diphenylmethyl group or C 1 -C 4 alkyl or alkoxy aromatic ring substituted derivatives thereof.
专利号:US-7109377-B2 优先权日:1996-10-16 标 题:Synthesis of combinatorial libraries of compounds reminiscent of natural products 发明人:SCHREIBER STUART L; SHAIR MATTHEW D; TAN DEREK S; FOLEY MICHAEL A; STOCKWELL BRENT R 权利人:HARVARD COLLEGE 摘要:The present invention provides complex compounds reminiscent of natural products and libraries thereof, as well as methods for their production. The inventive compounds and libraries of compounds are reminiscent of natural products in that they contain one or more stereocenters, and a high density and diversity of functionality. In general, the inventive libraries are synthesized from diversifiable scaffold structures, which are synthesized from readily available or easily synthesizable template structures. In certain embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from a shikimic acid based epoxyol template. In other embodiments, the inventive compounds and libraries are generated from diversifiable scaffolds synthesized from the pyridine-based template isonicotinamide. The present invention also provides a novel ortho-nitrobenzyl photolinker and a method for its synthesis. Furthermore, the present invention provides methods and kits for determining one or more biological activities of members of the inventive libraries. Additionally, the present invention provides pharmaceutical compositions containing one or more library members.
专利号:US-8765668-B2 优先权日:2010-06-04 标 题 :Methods of synthesis of β-aminobutyryl substituted compounds 发明人:STERK DAMJAN; USTAR MATJAZ; ZLICAR MARKO 权利人:STERK DAMJAN; USTAR MATJAZ; ZLICAR MARKO; LEK PHARMACEUTICALS 摘要:The present invention relates to process to prepare β-aminobutyryl compounds having β-amino acid core structural moieties and optionally having γ-phenyl and/or heterocyclic structural moieties. Such compounds are useful as key structure framework of modern drug chemistry.
专利号:US-4774366-A 优先权日:1985-01-31 标题 :Synthesis of geminal dinitro compounds 发明人:GRAKAUSKAS VYTAUTAS; GARVER LEE C; BAUM KURT 权利人:US AIR FORCE 摘要:Geminal dinitro compounds are prepared by reacting an organic nitro compound having a replaceable hydrogen on the carbon to which the nitro group is attached with a source of nitrite ions in the presence of an oxidizing agent and a catalytic amount of an alkali metal ferricyanide.
专利号:US-7772431-B1 优先权日:1999-07-27 标 题 :Performance of energy storage devices: potential areas for dendritic chemistry involvement 发明人:NEWKOME GEORGE R 权利人:NEWKOME GEORGE R 摘要:A compound consists of a fractal-like, plain or organometallic array useful for energy storage devices. A dendrimer useful in the synthesis of the fractal-like compound includes a single ligating moiety bound to a surface of each quadrant of the dendrimer. A method of making metallo-based (macro) molecules includes the steps of combining monomers selected from the group consisting of bipyridal- and terpyridal-based ligands with connecting metals and self assembling macrocycles wherein the monomes are interconnected by the metals.
1: Ranganayaki S, Jamshidi N, Aiyaz M, Rashmi SK, Gayathri N, Harsha PK, Padmanabhan B, Srinivas Bharath MM. Inhibition of mitochondrial complex II in neuronal cells triggers unique pathways culminating in autophagy with implications for neurodegeneration. Sci Rep. 2021 Jan 15;11(1):1483. doi: 10.1038/s41598-020-79339-2. 140:104846. doi: 10.1016/j.neuint.2020.104846. Epub 2020 Sep 11. 128:110291. doi: 10.1016/j.biopha.2020.110291. Epub 2020 Jun 8.
合成参考文献
参考文献:10.1007/s11596-010-0110-8 摘要:Dong X, Zhao H, Ma X, Wang S. Reduction in bile acid pool causes delayed liver regeneration accompanied by down-regulated expression of FXR and c-Jun mRNA in rats. J Huazhong Univ Sci Technolog Med Sci. 2010 Feb;30(1):55–60. doi: 10.1007/s11596-010-0110-8. 参考文献:10.18632/aging.100077 摘要:Hsieh CC, Papaconstantinou J. Dermal fibroblasts from long-lived Ames dwarf mice maintain their in vivo resistance to mitochondrial generated reactive oxygen species (ROS). Aging (Albany NY). 2009 Jul 31;1(9):784–802. 参考文献:10.1007/s10545-011-9375-8 摘要:Breuer ME, Willems PHGM, Russel FGM, Koopman WJH, Smeitink JAM. Modeling mitochondrial dysfunctions in the brain: from mice to men. J of Inher Metab Disea. 2011 Jul 14;35(2):193–210. doi: 10.1007/s10545-011-9375-8. 参考文献:10.1179/1476830511y.0000000005 摘要:Tasset I, Pontes AJ, Hinojosa AJ, de la Torre R, Túnez I. Olive oil reduces oxidative damage in a 3-nitropropionic acid-induced Huntington's disease-like rat model. Nutr Neurosci. 2011 May;14(3):106–11. doi: 10.1179/1476830511y.0000000005. 参考文献:10.1016/j.ntt.2011.07.002 摘要:Lugo-Huitrón R, Blanco-Ayala T, Ugalde-Muñiz P, Carrillo-Mora P, Pedraza-Chaverrí J, Silva-Adaya D, Maldonado PD, Torres I, Pinzón E, Ortiz-Islas E, López T, García E, Pineda B, Torres-Ramos M, Santamaría A, La Cruz VP. On the antioxidant properties of kynurenic acid: free radical scavenging activity and inhibition of oxidative stress. Neurotoxicol Teratol. 2011 Sep;33(5):538–47. doi: 10.1016/j.ntt.2011.07.002.