CAS: 452-67-5; 2,5-Difluorotoluene

上下游产品

CAS号95-52-3 邻氟甲苯 | CAS号455-88-9 2-氟-5-硝基甲苯 | CAS号495-07-8 2,5-二氟苄氯 | CAS号85117-99-3 2,5-二氟溴苄 | CAS号116465-48-6 2,5-二氟-4-硝基苯甲酸 | CAS号141412-60-4 2,5-二氟-4-硝基甲苯 | CAS号2646-90-4 2,5-二氟苯甲醛 | CAS号7498-31-9 L-Glutamicacid,...

2-氟-5-硝基甲苯 反应生成 2,5-二氟甲苯
参考文献:Jerumanis,S.; Bruylants,A.,Bulletin Des Societes Chimiques Belges,1960,Vol. 69,P. 312-322
标题:Jerumanis,S.; Bruylants,A.,Bulletin Des Societes Chimiques Belges,1960,Vol. 69,P. 312-322

专利信息

专利号:US-7148356-B2
优先权日:2001-07-13
标题:Process for the catalytic synthesis of biaryls and polymers from aryl compounds
发明人：SMITH III MILTON R; MALECZKA ROBERT E
权利人:UNIV MICHIGAN STATE
摘要:A process for producing organic substituted aromatic or heteroaromatic compounds including biaryl and biheteroaryl compounds in a two-step reaction. In the first step, the aromatic or heteroaromatic compound is borylated in a reaction comprising a borane or diborane reagent (any boron reagent where the boron reagent contains a B—H, B—B or B—Si bond) and an iridium or rhodium catalytic complex. In the second step, a metal catalyst catalyzes the formation of the organic substituted aromatic or heteroaromatic compound from the borylated compound and an electrophile such as an aryl or organic halide, triflate (OSO 2 CF 3 ), or nonaflate (OSO 2 C 4 F 9 ). The steps in the process can be performed in a single reaction vessel or in separate reaction vessels. The present invention also provides a process for synthesis of complex polyphenylenes starting from halogenated aromatic compounds.

专利号:US-RE42890-E
优先权日:2003-05-23
标题 :Furazanobenzimidazoles
发明人：EBERLE MARTIN; BACHMANN FELIX; STREBEL ALESSANDRO; ROY SUBHO; SRIVASTAVA SUDHIR; SAHA GOUTAM
权利人:BASILEA PHARMACEUTICA AG
摘要:The invention relates to compounds of formula (I) wherein R represents aryl or heteroaryl, X is oxygen, a carbonyl group, an oxime derivative of a carbonyl group or an α,β-unsaturated carbonyl group, and the substituents R 1 to R 6 have the meanings given in the specification, for use as medicaments, to novel compounds of formula (I), to methods of synthesis of such compounds, to pharmaceutical compositions containing compounds of formula (I), to the use of a compounds of formula (I) for the preparation of a pharmaceutical composition for the treatment of neoplastic and autoimmune diseases, and to methods of treatment of neoplastic and autoimmune diseases using such compounds of formula (I) or of pharmaceutical compositions containing same

专利号:US-8981092-B2
优先权日:2008-09-19
标题 :Substituted 3,4-dihydro-2H-pyrrolo[1,2-a]pyrazin-1-ones as modulators of protein kinase activity
发明人：MIRIZZI DANILO; CERVI GIOVANNI; D ANELLO MATTEO; PAPEO GIANLUCA MARIANO ENRICO; FERGUSON RON; CASUSCELLI FRANCESCO
权利人:MIRIZZI DANILO; CERVI GIOVANNI; D ANELLO MATTEO; PAPEO GIANLUCA MARIANO ENRICO; FERGUSON RON; CASUSCELLI FRANCESCO; NERVIANO MEDICAL SCIENCES SRL
摘要:Compounds which are 4,7-disubstituted derivatives of 3,4-dihydro-2H-pyrrolo[1,2-a]pyrazin-1-one compounds, n nor pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, viral infection, prevention of AIDS development in HIV-infected individuals, cell proliferative disorders, autoimmune and neurodegenerative disorders; also disclosed is a process under Solid Phase Synthesis conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.

专利号:US-7329769-B2
优先权日:2001-07-13
标 题:Catalytic boronate ester synthesis from boron reagents and hydrocarbons
发明人：SMITH III MILTON R
权利人:UNIV MICHIGAN STATE
摘要:A process for producing a ring-substituted arene borane which comprises reacting a ring-substituted arene with an HB organic compound in the presence of a catalytically effective amount of an iridium or rhodium complex with three or more substituents, excluding hydrogen, bonded to the iridium or rhodium and a phosphorus organic ligand, which is at least in part bonded to the iridium or rhodium, to form the ring-substituted arene borane. Also provided are catalytic compounds for catalyzing the process comprising an iridium or rhodium complex with three or substituents, excluding hydrogen, bonded to the iridium or rhodium and optionally, a phosphorus organic ligand, which is at least in part bonded to the iridium or rhodium.

专利号:US-2005182261-A1
优先权日:2001-07-13
标 题:Process for the catalytic synthesis of biaryls and polymers from aryl compounds

专利号:US-8455479-B2
优先权日:2008-01-24
标 题 :Heterocyclic compounds
发明人：JAIN RAJESH; TREHAN SANJAY; DAS JAGATTARAN; SINGH NISHAN; NANDA GURMEET KAUR; MAGADI SITARAM KUMAR; SHARMA SUDHIR KUMAR
权利人:JAIN RAJESH; TREHAN SANJAY; DAS JAGATTARAN; SINGH NISHAN; NANDA GURMEET KAUR; MAGADI SITARAM KUMAR; SHARMA SUDHIR KUMAR; PANACEA BIOTEC LTD
摘要:The present invention relates to novel compounds of Formula I, their pharmaceutically acceptable derivatives, tautomeric forms, stereoisomers including R and S isomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The invention also relates to the processes for the synthesis of novel compounds of Formula I, their pharmaceutically acceptable derivatives, tautomeric forms, stereoisomers, polymorphs, prodrugs, metabolites, salts or solvates thereof. The present invention also provides pharmaceutical compositions comprising compounds of Formula I and methods of treating or preventing one or more conditions that may be regulated or normalized via inhibition of dipeptidyl peptidase IV (DPP-IV).