CAS: 4461-29-4; Thiophene-2-Acetamide

上下游产品

CAS号20893-30-5 2-噻吩乙腈 | CAS号1918-77-0 2-噻吩乙酸 | CAS号88-15-3 2-乙酰基噻吩 | CAS号1918-82-7 2-乙烯基噻吩 | CAS号19432-68-9 2-噻吩乙酸甲酯 | CAS号115510-91-3 1-(thien-2-yl)e... | CAS号98-03-3 2-噻吩甲醛 | CAS号89677-36-1 2-Thiopheneprop... | CAS号6319-47-7 2-sulfanylidene... | CAS号139109-61-8 2-hydroxyimino-... | CAS号20893-30-5 2-噻吩乙腈 | CAS号1003-31-2 2-氰基噻吩 | CAS号62220-82-0 N-(hydroxymethy...

📜2-乙酰基噻吩置于ammonium Hydroxide,Sulfur体系中,用 乙醇 作为反应溶剂,120.0 °C,2.0 Mpa 条件下,反应 8.0H,以99.5%的收率获得产物噻酚-2-乙酰胺
参考文献:一种2-噻吩甲胺的合成方法
标题:一种2-噻吩甲胺的合成方法
摘要:本发明是一种2‑噻吩甲胺的合成方法:原料2‑乙酰噻吩和乙醇,浓氨水,硫磺粉在0.08~2.00Mpa的条件下,反应生产2‑噻吩乙酰胺,2‑噻吩乙酰胺和次氯酸钠或者次溴酸钠在液碱作用下,通过霍夫曼降解,反应生成2‑噻吩甲胺.本发明合成方法原料易得,工艺简单可控,可操作性强,所制得的成品纯度高,收率高.

专利信息

专利号:EP-0439404-B1
优先权日:1990-01-25
标题 :Preparation of 2-(2'-thienyl) alkylamines and derivatives thereof and synthesis of 4,5,6,7- thieno [3,2-c] pyridine derivatives therefrom
发明人：KHATRI HIRALAL N; DEHOFF BRADLEY S
权利人:SANOFI SA
摘要:An improved process for the synthesis of 2-(2 min -thienyl)ethylamine from suitably functionalized derivatives of 2-(2 min -thienyl)ethanol employing ammonia gas in the presence of a metal salt or liquid ammonia and alkyl ketone as a solvent. The 2-(2 min -thienyl)ethylamine produced by this process is advantageously converted to the carbamic acid salt, which is suitably reconverted to 2-(2 min -thienyl)ethylamine, a useful intermediate in the synthesis of ticlopidine.

专利号:US-5068360-A
优先权日:1990-01-25
标题 :Preparation of 2-(2'-thienyl)ethylamine derivatives and synthesis of thieno(3,2-C)pyridine derivatives therefrom
发明人：DEHOFF BRADLEY S
权利人:SYNTEX INC
摘要:An improved process for the synthesis of 2-(2'-thienyl)ethylamine from suitably functionalized derivatives of 2-(2'-thienyl)ethanol employing ammonia gas in the presence of a metal salt or liquid ammonia and alkyl ketone as a solvent. The 2-(2'-thienyl)ethylamine produced by this process is advantageously converted to ticlopidine.

专利号:US-5191090-A
优先权日:1990-01-25
标题:Preparation of 2-(2'-thienyl)ethylamine derivatives and synthesis of thieno[3,2-c]pyridine derivatives therefrom
发明人：DEHOFF BRADLEY S
权利人:SYNTEX INC
摘要:An improved process for the synthesis of 2-(2'-thienyl)ethylamine from suitably functionalized derivatives of 2-(2'-thienyl)ethanol employing ammonia gas in the presence of a metal salt or liquid ammonia and alkyl ketone as a solvent. The 2-(2'-thienyl)ethylamine produced by this process is advantageously converted to ticlopidine.

专利号:EP-0051234-B1
优先权日:1980-10-31
标题:A process for the production of a 2-azetidinone derivative
摘要:A new and efficient process of producing a 2-azetidinone derivative is provided, which comprises cyclizing a beta -amino acid by treating with triphenylphosphine and a heterocyclic disulfide in the presence of an alkylnitrile. The 2-azetidinone derivatives produced are useful as starting compound for synthesis of beta -lactam group antibiotics such as thienamycin and nocardicin.

专利号:US-5516910-A
优先权日:1991-01-31
标题:N--2--chlorobenzyl--2--oxo and n--2--chlorobenzyl--2,2--dioxo--1,2,3--oxathiazolidine derivatives, their preparation and synthesis of thieno[3,2--c]pyridine derivatives therefrom
发明人：COOPER GARY F; MCCARTHY KEITH E
权利人:SYNTEX INC
摘要:Compounds of the formula: ##STR1## wherein: A is oxo or dioxo; n R 1 , R 2 and R 3 are independently hydrogen or lower alkyl of one to six carbon atoms; n R 4 , R 5 , R 6 and R 7 are independently hydrogen, lower alkyl of one to six carbon atoms, alkoxy, acyl or halo; n are advantageously converted to thieno[3,2-c]pyridine derivatives and the pharmaceutically acceptable salts thereof, particularly ticlopidine hydrochloride.

专利号:EP-0522956-B1
优先权日:1991-07-08
标 题 :Preparation of 2-(2-thienyl) ethylamine and synthesis of thieno [3,2-C] pyridine derivatives therefrom
发明人：HARRINGTON PETER J; SANCHEZ IGNACIO H
权利人:SANOFI SA
摘要:Compounds of the formulae: and wherein: R<1>, R<2>, R<3> and R<4> are independently hydrogen, lower alkyl of one to six carbon atoms, aryl or substituted aryl; are advantageously converted to isocyanurate compounds, 2-(2-thienyl)ethylamine compounds and thieno[3,2-c]pyridine derivatives and the pharmaceutically acceptable salts thereof, particularly ticlopidine hydrochloride.