CAS: 442851-50-5; (S)-5-(4-Fluorophenyl)-2-Isopropyl-1-(2-(6-Oxo-3,6-Dihydro-2H-Pyran-2-yl)Ethyl)-N,4-Diphenyl-1H-Pyrrole-3-Carboxamide
- 英文名称(S)-5-(4-Fluorophenyl)-2-Isopropyl-1-(2-(6-Oxo-3,6-Dihydro-2H-Pyran-2-yl)Ethyl)-N,4-Diphenyl-1H-Pyrrole-3-Carboxamide
- 中文名称3-脱羟基2,3-去氢阿托伐他汀内酯
- IUPAC名称5-(4-fluorophenyl)-1-[2-[(2S)-6-oxo-2,3-dihydropyran-2-yl]ethyl]-N,4-diphenyl-2-propan-2-ylpyrrole-3-carboxamide
- CAS编号442851-50-5
- EINECS号:642-041-2
- FDA UNII编号:PTF3BL2VKD
- 分子式:C33H31FN2O3分子量:522.61
- 产品CID: 1451106
- 产品分类分析化学 → 标准品 → 药典标准品和杂质标准品
- 相似结构搜索
- InChIKey: GYIXAUAZYJKKST-MHZLTWQESA-N
- GYIXAUAZYJKKST-MHZLTWQESA-N
- 计算化学: 氢键受体数4.0氢键供体数1.0可旋转键数8.0
物理性质
MSDS等安全信息
上下游产品
lipitor合成工艺路线路线简述
📜Lipitor置于对甲苯磺酸体系中,用 甲苯 作为反应溶剂,化学反应 5.0H,以95%的收率获得产物3-脱羟基2,3-去氢阿托伐他汀内酯
参考文献:用强酸处理后形成的两种新的阿托伐他汀钙降解产物的表征
标题:用强酸处理后形成的两种新的阿托伐他汀钙降解产物的表征
摘要:阿托伐他汀钙(立普妥®,Sortis ®)是一种建立非常好的胆固醇合成酶(cse)抑制剂,通常用于治疗高胆固醇血症.已知该药物对酸处理敏感,但有关降解产物的结构的数据很少.在这里,我们报告鉴定两个仅在剧烈酸性条件下形成的阿托伐他汀的新型降解产物.同时用浓密治疗.用浓硫酸处理会导致羧酰苯胺残留物的损失(伴随侧链预期的内酯化/脱水过程).在盐酸水溶液中,内酯部分与吡咯在c-C键下形成复杂的桥连分子,异丙基迁移,羧酰苯胺残基丢失.通过NMR光谱对新型降解产物进行了表征,
DOI:10.3762/bjoc.15.206
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2905122000-异丙醇
2909110000-乙醚 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-7399773-B2
优先权日:2001-01-09
标 题 :Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid and phenylamide
发明人：NELSON JADE DOUGLAS; PAMMENT MICHAEL GERARD
权利人:WARNER LAMBERT CO
摘要:An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight operations or fewer to the desired product, as well as other valuable intermediates used in the process.
专利号:US-2003195353-A1
优先权日:2001-01-09
标题 :Novel process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo- tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide
专利号:US-7183408-B2
优先权日:2001-01-09
标题:Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide
专利号:US-6476235-B2
优先权日:2001-01-09
标 题:Process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide
专利号:WO-02055519-A2
优先权日:2001-01-09
标 题:Novel process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2r, 4r)-4-hydroxy -6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1h-pyrrole-3-carboxylic acid phenylamide
专利号:US-2007032663-A1
优先权日:2001-01-09
标题:Novel process for the synthesis of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl-4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
参考标题: Process For Preparing 5-(4-Fluorophenyl)-1-[2R,4R)-4-Hydroxy-6-Oxo-Tetrahydro-Pyran-2-Yl)Ethyl]-2-Isopropyl-4-Phenyl-1H-Pyrrole-3-Carboxylic Acid Phenylamide Procede De Preparation De Phenylamide D'Acide Carboxylique 5-(4-Fluorophenyl)-1-[2-((2R,4R)-4-Hydroxy-6-Oxo-Tetrahydro-Pyran-2-Yl)Ethyl]-2-Isopropyl-4-Phenyl-1H-Pyrrole-3摘要:A Method For Preparing 5-(4-Fluorophenyl)-1-[2-((2R,4R)-4-Hydroxy-6-Oxo-Tetrahydro-Pyran-2-Yl)Ethyl]-2-Isopropyl-4-Phenyl-1H-Pyrrole-3-Carboxylic Acid Phenylamide (I), A Key Intermediate In The Synthesis Of Atorvastatin Calcium, Is Described.
合成参考文献
合成方法参考DOI号:10.3762/bj°C.15.206
📝 需求与反馈
尽可能描述清楚需求与问题信息
