CAS: 31462-58-5; 5-Iodopyrimidine

相似化合物

32779-38-7 905856-70-4 697300-79-1

上下游产品

CAS号289-95-2 嘧啶 | CAS号58759-01-6 5-thiophen-2-yl... | CAS号58759-02-7 5-(thiophen-3-y... | CAS号63558-71-4 Pyrimidine, 5-(...

📜嘧啶置于n-碘代丁二酰亚胺体系中,用 乙醇,溶剂黄146 作为反应溶剂,化学反应生成 5-碘嘧啶
参考文献:Method For Treating Arthritis With 6-Aryl Pyrimidine Compounds
标题:Method For Treating Arthritis With 6-Aryl Pyrimidine Compounds
摘要:这项发明涉及6-芳基嘧啶化合物,现已发现其可用于治疗或预防关节炎.

专利信息

专利号:US-9845501-B2
优先权日:1998-12-14
标题 :System and methods for nucleic acid sequencing of single molecules by polymerase synthesis
发明人：WILLIAMS JOHN G K
权利人:PACIFIC BIOSCIENCES CALIFORNIA INC; PACIFIC OF BIOSCIENCES OF CALIFORNIA INC
摘要:This invention relates to improved methods for sequencing and genotyping nucleic acid in a single molecule configuration. The method involves single molecule detection of fluorescent labeled PPi moieties released from NTPs as a polymerase extension product is created.

专利号:US-3869456-A
优先权日:1972-03-13
标 题 :Synthesis of 5-pyrimidinecarbinols
发明人：TAYLOR HAROLD M; DAVENPORT JAMES D; HACKLER RONALD E
权利人:LILLY CO ELI
摘要:There is disclosed an improved method of synthesizing 5pyrimidinecarbinols by the addition of an alkyllithium to a mixture of 5-halopyrimidine and a ketone at a low temperature. The product compounds are useful as plant fungicides and as plant growth regulators.

专利号:US-6288221-B1
优先权日:1998-08-20
标 题 :Methods of synthesis of halogen base-modified oligonucleotides and subsequent labeling with a metal-catalyzed reaction
发明人：GRINSTAFF MARK W; BEILSTEIN AMY E; KHAN SHOEB I
权利人:UNIV DUKE
摘要:The present invention provides metal-containing purines, pyrimidines, nucleosides, nucleotides and oligonucleotides; including phosphoramidite and photolabile derivatives thereof, including methods of making and method of using same. The present invention provides a method for detection of nucleic acid sequences via electrochemical or photochemical means.

专利号:US-7544794-B1
优先权日:2005-03-11
标题 :Method for sequencing DNA and RNA by synthesis
发明人：BENNER STEVEN ALBERT
权利人:BENNER STEVEN ALBERT
摘要:This invention relates to the field of nucleic acid chemistry, more specifically to the field of compositions and processes that are nucleic acid analogs. More specifically, this invention relates to compositions that allow the sequencing of oligonucleotides by synthesis, and processes for sequencing by synthesis that exploit these compositions. Most specifically, the instant invention discloses compositions of matter that are 5′-triphosphates of ribo- and 2′-deoxyribonucleosides wherein the 3′-OH group is replaced by a 3′-ONHR group in the alpha configuration, wherein R is either a H or CH 3 group. Also disclosed are these triphosphates where the nucleobase carries, via a linker, a reporter groups, such as a fluorescent species that can be used in single- or multi-copy DNA sequencing, or a tag that can be visualized by ultramicroscopy. Also disclosed are processes that use these compositions to do sequencing by synthesis.

专利号:WO-2021062168-A1
优先权日:2019-09-25
标 题 :Synthetic sphingolipid inspired molecules with heteroaromatic appendages, methods of their synthesis and methods of treatment
发明人：EDINGER AIMEE; HANESSIAN STEPHEN
权利人:UNIV CALIFORNIA; UNIV MONTREAL
摘要:Small molecules compounds and methods of their synthesis are provided. Formulations and medicaments are also provided that are directed to the treatment of disease, such as, for example, neoplasms, cancers, and other diseases. Therapeutics are also provided containing a therapeutically effective dose of one or more small molecule compounds, present either as pharmaceutically effective salt or in pure form, including, but not limited to, formulations for oral, intravenous, or intramuscular administration.

专利号:US-7179906-B2
优先权日:1996-04-01
标 题 :Asymmetric benzoxanthene dyes
发明人：BENSON SCOTT C; MENCHEN STEVEN M; THEISEN PETER D; HENNESSEY KEVIN M; FURNISS VERGINE C; HAUSER JOAN D
权利人:APPLERA CORP
摘要:A class of asymmetric monobenzoxanthene compounds useful as fluorescent dyes are disclosed having the structure n nwherein Y 1 and Y 2 are individually hydroxyl, amino, imminium, or oxygen, R 1 –R 8 are hydrogen, fluorine, chlorine, alkyl, alkene, alkyne, sulfonate, amino, amido, nitrile, alkoxy, linking group, and combinations thereof, and R 9 is acetylene, alkane, alkene, cyano, substituted phenyl, and combinations thereof. The invention further includes novel intermediate compounds useful for the synthesis of asymmetric benzoxanthene compounds having the general structuren n nwhere substituents R 3 –R 7 correspond to like-referenced substituents in the structure of described above, and Y 2 is hydroxyl or amine. In another aspect, the invention includes methods for synthesizing the above dye compounds and intermediates. In yet another aspect, the present invention includes reagents labeled with the asymmetric benzoxanthene dye compounds, including deoxynucleotides, dideoxynucleotides, phosphoramidites, and polynucleotides. In an additional aspect, the invention includes methods utilizing such dye compounds and reagents including dideoxy polynucleotide sequencing and fragment analysis methods.