CAS: 250285-32-6; 1,3-Bis(2,6-Diisopropylphenyl)Imidazolium Chloride

相似化合物

1157867-61-2 286014-25-3 934008-48-7

上下游产品

1,2-bis(2,6-diisopropylphenylimino)ethane ethyl chloromethyl ether formaldehyd 1,N2-bis(2,6-diisopropylphenyl)-ethane-1,2-diimine(1E,2E)-N1,N2-bis(2,6-diisopropylphenyl)-ethane-1,2-diimine 1,3-bis-(2,6-diisopropylphenyl)-imidazol-2-ylidene 1,3-bis(2,6-diisopropylphenyl)imidazolylium-2-carboxylate 1,3-bis-(2,6-diisopropylphenyl)-4,5-dichloroimidazol-2-ylidene chloro[1,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene]copper(I)

{1,3-Bis[2,6-Di(Propan-2-yl)Phenyl]-1,3-Dihydro-2H-Imidazol-2-Ylidene}(Dichloro)(N,N-Diethylethanamine)Palladium置于三乙胺体系中,用 氘代氯仿,N,N-二甲基甲酰胺 用作溶剂,化学反应 21.0H,反应生成1,3-双(2,6-二异丙基苯基)氯化咪唑鎓
参考文献:防止pd-nhc键断裂并从纳米级转换为分子催化系统:胺和温度作为催化剂活化剂
标题:防止pd-nhc键断裂并从纳米级转换为分子催化系统:胺和温度作为催化剂活化剂
摘要:Pd配合物与n-杂环卡宾(nhc)配体催化的许多反应都是在通常存在偶合剂或弱碱的胺存在下进行的.但是,胺可以通过多种方式与pd / Nhc配合物反应:通过产生不含nhc的活性钯物质,增强分子催化作用,引起催化剂失活或触发无配体催化方式.这项研究深入了解了有效使用胺作为分子pd / Nhc催化活化剂和防止催化体系中pd-Nhc键发生不希望的还原裂解所需的条件.在25-140oc的温度范围内,检测了pd / Nhc配合物与各种胺的反应以及所得氨基配合物的热稳定性.结果表明胺结构和反应温度对催化剂转化的主要影响.特别是,Pd / Nhc配合物与脂肪族胺配体的热分解主要导致还原性pd-Nhc键裂解,而在强碱存在下,在25-60oc下,具有伯和仲脂肪族胺配体的配合物的去质子化促进了激活分子pd / Nhc催化.在这些发现的基础上,提出了适用于强碱促进的芳基卤化物和硫醇之间的cs交叉偶联反应的高效pd
Doi:10.1039/c9Cy02041A

专利信息

专利号:WO-2025119975-A1
优先权日:2023-12-04
标 题:A method for synthesis of harmine
发明人：HETT ROBERT; GRAB HANUSCH; LAGOUTTE ROMAN
权利人:RECONNECT LABS AG
摘要:The invention relates to a method of synthesis of a compound of formula (I), harmine, according to the method comprising a step of transforming the compound of formula (II), into the compound of formula (I). The invention further relates to a compound of formula (II), which is an intermediate in synthesis of harmine according to the present invention.

专利号:WO-2014037963-A1
优先权日:2012-09-06
标 题 :A PROCESS FOR THE SYNTHESIS OF β, Æ´ UNSATURATED KETONES
发明人：MHASKE SANTOSH BABURAO; AHIRE MILIND MUKUND
权利人:COUNCIL SCIENT IND RES
摘要:The present invention disclose Pd/ N -Heterocyclic carbene catalyzed one step process for synthesis of β, Æ´-unsaturated ketones by direct acylation of allylic Carbons with aldehydes.

专利号:US-8071783-B2
优先权日:2007-03-16
标题:N-heterocyclic carbene catalyzed synthesis of N-phenylisoxazolidin-5-one derivative and synthesis of β-amino acid ester derivative
发明人：ZHANG YUGEN; YING JACKIE Y; SEAYAD JAYASREE; PATRA PRANAB K
权利人:ZHANG YUGEN; YING JACKIE Y; SEAYAD JAYASREE; PATRA PRANAB K; AGENCY SCIENCE TECH & RES
摘要:A process for preparing a N-phenylisoxazolidin-5-one derivative is provided. The process for preparing the N-phenylisoxazolidin-5-one derivative comprises reacting an α,β-unsaturated aldehyde with nitrosobenzene in the presence of a N-heterocyclic carbene (NHC) catalyst. A process for preparing an N-alkoxyphenyl protected β-amino acid ester derivative is further provided. The process for preparing the N-alkoxyphenyl protected β-amino acid ester derivative comprises reacting an α,β-unsaturated aldehyde with nitrosobenzene in the presence of a N-heterocyclic carbene (NHC) catalyst to form a N-phenylisoxazolidin-5-one derivative, and then treating the N-phenylisoxazolidin-5-one derivative with an alcohol in the presence of an acid catalyst. A process for preparing an N-alkoxyphenyl protected β-amino acid ester derivative, comprising treating a N-phenylisoxazolidin-5-one derivative with an alcohol in the presence of an acid catalyst, is also provided.

专利号:US-7109348-B1
优先权日:2002-08-30
标题 :Synthesis of 1,3 distributed imidazolium salts
发明人：NOLAN STEVEN P
权利人:UNIV NEW ORLEANS RES AND TECHN
摘要:Imidazolium salts are the immediate precursors to N-heterocyclic carbenes (NHC) yet a simple, general synthetic route to a wide variety of imidazolium salts is not yet available. Such a straightforward route is described for two specific members of this family of ligand precursor: 1,3-Bis(2,4,6-trimethylphenyl)imidazolium chloride (IMes.HCl) and 1,3-Bis(2,6-diispropylphenyl)imidazolium chloride (IPr.HCl). The procedure appears general and similar protocols can be used to isolate various imidazolium salts.

专利号:US-10077242-B2
优先权日:2014-12-01
标题 :Convergent approach to the total synthesis of telmisartan via a suzuki cross-coupling reaction
发明人：GUPTON FRANK; MARTIN ALEX; SIAMAKI ALI; BELECKI KATHERINE
权利人:UNIV VIRGINIA COMMONWEALTH
摘要:Methods of synthesizing the angiotensin II receptor antagonist telmisartan in high yield and purity are provided. The methods involve the coupling of two structurally distinct benzimidazole units via a Suzuki cross-coupling reaction. Methods of regioselectively synthesizing one of the benzimidazole units are also provided.

专利号:US-10457640-B2
优先权日:2016-10-19
标 题:Synthesis of inhibitors of EZH2
发明人：VASWANI RISHI G; HEWITT MICHAEL CHARLES
权利人:CONSTELLATION PHARMACEUTICALS INC
摘要:Provided herein are synthetic methods for the preparation of EZH2 inhibitors.