CAS: 2419-56-9; H-Glu(Otbu)-Oh

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H-Glu(O-T-Bu)-Obzl置于palladium On Activated Charcoal 氢气体系中,用 乙醇 用作溶剂,化学反应生成L-谷氨酸-5-叔丁基酯
参考文献:Preparation Of T-Butyl Esters Of Free Amino Acids1
标题:Preparation Of T-Butyl Esters Of Free Amino Acids1
摘要:
Doi:10.1021/jo01040A022

专利信息

专利号:US-2019177392-A1
优先权日:2014-09-23
标 题 :Synthesis of glp-1 peptides
发明人：PENIAS NAVON SHARON; NAVEH SHIRLY; VASILEIOU ZOI; BARLOS KONSTANTINOS
权利人:NOVETIDE LTD
摘要:Disclosed are processes for the synthesis of GLP-1 peptides, such as liraglutide and semaglutide, and a process for purifying liraglutide.

专利号:US-8846614-B2
优先权日:2011-08-25
标 题 :Process for the synthesis of 37-mer peptide pramlintide
发明人：MOHE NIKHIL UMESH; CHAVRE PRAFUL SHAMRAO; DESHMUKH BHARTI PRABHAKARRAO; MURALIDHARAN CHANDRAKESAN; LOBO LESTER JOHN; PAWAR DIGAMBER SHRIPATI; SAKSENA DIVYA LAL
权利人:MOHE NIKHIL UMESH; CHAVRE PRAFUL SHAMRAO; DESHMUKH BHARTI PRABHAKARRAO; MURALIDHARAN CHANDRAKESAN; LOBO LESTER JOHN; PAWAR DIGAMBER SHRIPATI; SAKSENA DIVYA LAL; USV LTD
摘要:A process for the production of pramlintide, a 37-mer peptide, is provided. The synthesis provides a high yield synthesis of the peptide in relatively pure form. Further purification can be achieved by preparative HPLC.

专利号:US-6316593-B1
优先权日:1996-02-09
标题:Synthesis of VIP analog
发明人：BOLIN DAVID ROBERT; DANHO WALEED; FELIX ARTHUR M
权利人:HOFFMANN LA ROCHE
摘要:This invention relates to a novel process for the synthesis of vasoactive intestinal peptide analog Ac(1-31)-NH2 from four protected peptide fragments.

专利号:EP-2607373-A1
优先权日:2011-12-23
标 题 :Liquid phase synthesis of self-assembling peptides to be linked to polymers or to other bioactive and/or self-assembling peptides
发明人：MOUSSA WAFA; JEANNIN LAURENT; CALLENS ROLAND; BOUSMANNE MARTIN
权利人:SOLVAY
摘要:The present invention relates to a process for preparing a peptide moiety comprising an amino acid sequence (I) n€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ R-Xaa1-Xaa5-Xaa3-Xaa6-R1€ƒ€ƒ€ƒ€ƒ€ƒ(I), nwherein R1 is selected from OH and NH 2 nand a peptide moiety comprising an amino acid sequence (II) n€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ H-Xaa1-Xaa2-Xaa3-Xaa4-Xaal-Xaa5-Xaa3-Xaa6-R1€ƒ€ƒ€ƒ€ƒ€ƒ(II), nwherein R1 is selected from OH and NH 2 nwhereby Xaa1 and Xaa3 are residues of hydrophobic amino acids and are preferably selected from the group consisting of phenylalanine, tryptophan, histidine, tyrosine, isoleucine, alanine, leucine, norleucine and valine ; and Xaa2, Xaa4, Xaa5 and Xaa6 are residues of charged amino acids and are preferably selected from the group consisting of arginine, aspartic acid, glutamic acid and lysine. The invention further relates to a process for synthesis of a polymer covalently linked with at least one peptide, wherein the peptide comprises said peptide moiety.

专利号:EP-1071442-B9
优先权日:1998-03-23
标题:Methods and compositions for peptide synthesis (t-20)
发明人：KANG MYUNG-CHOL; BRAY BRIAN; LICHTY MAYNARD; MADER CATHERINE; MERUTKA GENE
权利人:TRIMERIS INC
摘要:The present invention relates, first, to methods for the synthesis of peptides, in particular T-20 (also referred to as 'DP-178'; SEQ ID NO:1) and T-20-like peptides. Such methods utilize solid and liquid phase synthesis procedures to synthesize and combine groups of specific peptide fragments to yield the peptide of interest. The present invention further relates to individual peptide fragments which act as intermediates in the synthesis of the peptides of interest (e.g., T-20). The present invention still further relates to groups of such peptide intermediate fragments which can be utilized together to produce full length T-20 and T-20-like peptides.

专利号:US-6281331-B1
优先权日:1998-03-23
标 题 :Methods and compositions for peptide synthesis
发明人：KANG MYUNG-CHOL; BRAY BRIAN; LICHTY MAYNARD; MADER CATHERINE
权利人:TRIMERIS INC
摘要:The present invention relates, first, to methods for the synthesis of peptides, in particular T-20 (also referred to as 'DP-178'; SEQ ID NO:1) and T-20-like peptides. Such methods utilize solid and liquid phase synthesis procedures to synthesize and combine groups of specific peptide fragments to yield the peptide of interest. The present invention further relates to individual peptide fragments which act as intermediates in the synthesis of the peptides of interest (e.g., T-20). The present invention still further relates to groups of such peptide intermediate fragments which can be utilized together to produce full length T-20 and T-20-like peptides.