CAS: 19158-51-1; 4-Methylbenzenesulfonyl Cyanide

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CAS号824-79-3 对甲苯亚磺酸钠 | CAS号506-77-4 氯化氰 | CAS号35274-27-2 2-(p-tolylsulph... | CAS号112033-21-3 2-butyl-4-[(4-m... | CAS号374633-37-1 2-溴-5-氰基-3-甲基吡啶 | CAS号49805-30-3 氮杂双环 | CAS号31909-58-7 2-呋喃甲酰乙腈 | CAS号3288-99-1 对叔丁基苯乙腈 | CAS号56182-43-5 2-溴噻吩-3-腈 | CAS号18791-98-5 3-溴噻吩-2-甲腈 | CAS号4464-60-2 双(苯并[d]噻唑-2-基)甲酮 | CAS号2602-85-9 2-氰基苯并噻唑

4-Tolyl Thiocyanate置于chromium(Vi) Oxide,高碘酸体系中,用 乙腈 用作溶剂,化学反应 2.0H,反应生成4-甲苯磺酰氰
参考文献:未活化的烷基溴和芳烃磺酰氰的镍催化还原硫醇化
标题:未活化的烷基溴和芳烃磺酰氰的镍催化还原硫醇化
摘要:开发了未活化的烷基溴与芳烃磺酰氰在还原条件下由 Ni(Acac) 2催化形成不对称硫化物的交叉亲电偶联.这种硫化物合成方法是实用的,依赖于可用的非官能化材料,例如烷基(伪)卤化物,并且具有可扩展性.这种催化策略为在温和条件下制备具有非常好官能团耐受性的不对称烷基-芳基硫化物提供了一种补充方法.
Doi:10.1021/acs.Joc.1C00903

专利信息

专利号:US-11479577-B2
优先权日:2016-05-18
标题:Intermediates for the synthesis of bile acid derivatives, in particular of obeticholic acid
发明人：WEYMOUTH-WILSON ALEXANDER; KOMSTA ZOFIA; WALLIS LAURA; EVANS TIMOTHY; DAVIES IEUAN; OTTER CARL; BATCHELOR RHYS
权利人:NZP UK LTD
摘要:The present invention relates to compounds which are intermediates in the synthesis of bile acid derivatives with pharmacological activity. The invention relates to compounds of general formula (I):wherein:, R1, R2, R3, R4, R5, R6 and Y are as defined herein.The compounds are intermediates in the synthesis of synthetic bile acids which are useful in the treatment of conditions such as liver disease. In addition, the invention relates to a method of synthesizing these intermediates and a method of preparing obeticholic acid and obeticholic acid analogues from the compounds of the invention.

专利号:US-6271379-B1
优先权日:2000-03-08
标题:Intermediates useful for the synthesis of huperzine A
发明人：TUECKMANTEL WERNER; KOZIKOWSKI ALAN P
权利人:UNIV GEORGETOWN
摘要:Intermediates useful for the synthesis of huperzine A represented by the structures below, n and methods for their synthesis, wherein: n R 1 is lower alkyl, benzyl, or substituted benzyl; n X is a suitable leaving group; n Y is an electron withdrawing group that can subsequently be converted into an amino group; n one broken line is present as a carbon—carbon bond and the other broken line is absent, where the broken line forms an unconjugated carbon—carbon double bond, which double bond may be endocyclic whereby n is 3 or the double bond may be exocyclic whereby n is 2.

专利号:US-10766921-B2
优先权日:2016-05-18
标 题 :Process and intermediates for the 6,7-alpha-epoxidation of steroid 4,6-dienes
发明人：WEYMOUTH-WILSON ALEXANDER; KOMSTA ZOFIA; WALLIS LAURA; EVANS TIMOTHY
权利人:NZP UK LTD
摘要:The invention relates to a process for preparing a compound of general formula (Ia): wherein R2, Y, R4 and R5 are as defined herein, wherein the epoxidation is conducted using an oxidant and methyltrioxorhenium as a catalyst (MeReO3). The invention also relates to certain compounds per se. The compounds are intermediates in the synthesis of synthetic bile acids.

专利号:US-5688933-A
优先权日:1989-10-16
标题 :Preparation of biologically active compounds from substantially pure enantiomers of 2-azabicyclo 2.2.1!hept-5-en-one
发明人：EVANS CHRISTOPHER THOMAS; ROBERTS STANLEY MICAHEL
权利人:CHIROSCIENCE LTD
摘要:Lactams of 1-amino-3-carboxylic acid cyclic compounds are provided in enantiomeric form, together with an enantiomer of the corresponding ring-opened amino-acid or ester, by reaction of the racemic lactam with a novel lactamase. The products are useful in the synthesis of chiral carbocyclic nucleotides. The enantiomer is preferably 2-azabicyclo 2.2.1!hept-5-en-3-one.

专利号:US-5284769-A
优先权日:1989-10-16
标题 :Process for preparing a single enantiomer of a lactam using lactamase
发明人：EVANS CHRISTOPHER T; ROBERTS STANLEY M
权利人:CHIROS LTD
摘要:Lactams of 1-amino-3-carboxylic acid cyclic compounds are produced in enantiomeric form, together with an enantiomer of the corresponding ring-opened amino-acid or ester, by reaction of the racemic lactam with a novel lactamase. The products are useful in the synthesis of chiral carbocyclic nucleotides.

专利号:WO-2007093765-A1
优先权日:2006-02-13
标题 :Process for the cyanation of aldehydes
发明人：NORTH MICHAEL; BELOKON YURI
权利人:NPIL PHARMACEUTICALS UK LTD; NORTH MICHAEL; BELOKON YURI
摘要:The present invention relates to a process for the cyanation of aldehydes, particularly to the asymmetric cyanation of aldehydes, including the synthesis of chiral cyanohydrins and derivatives thereof, such as chiral O-acyl cyanohydrins. The process of the present invention comprises: reacting the aldehyde with a cyanating agent in the presence of a chiral catalyst and less than a stoichiometric amount of an ionic cyanide source. Chiral catalysts employed in the process according to the present invention are of the formula: (1), (3a), (3b).