CAS: 17476-04-9; Lithium Tri-Tert-Butoxyaluminum Hydride

专利信息

专利号:US-2019047933-A1
优先权日:2016-03-15
标 题:Process for the synthesis of (2e, 4e, 6z, 8e)-8-(3,4-dihydronaphthalen-1(2h)-ylidene)-3,7-dimethylocta-2, 4, 6-trienoic acid
发明人：ABEL ULRICH; RÉPÃ?SI JÓZSEF; Szabó András; SZÃœCSNÉ CSERÉPI STEFÃ?NIA; Bor Ã?dám
权利人:ABEL ULRICH; REPASI JOZSEF; SZABO ANDRAS; SZUECSNE CSEREPI STEFANIA; BOR ADAM; BRICKELL BIOTECH INC
摘要:This invention relates to a novel method for the synthesis of (2E,4E,6Z,8E)-8-(3,4-dihydronaphthalen-1(2H)-ylidene)-3,7-dimethylocta-2,4,6-trienoic acid. In particular, the invention relates to several improvements in several individual steps of the multi-step synthesis scheme

专利号:US-3992413-A
优先权日:1975-07-25
标 题 :Intermediates in the synthesis of prostaglandins
发明人：TAUB DAVID; WENDLER NORMAN L
权利人:MERCK & CO INC
摘要:The invention relates to a new and novel synthesis of prostaglandin E 2 , and it particularly relates to a novel process starting with relatively inexpensive starting materials. The invention further relates to a synthesis which is readily adaptable for large scale processing because of the high yields in the individual reaction steps. n The invention further relates to novel compounds formed as intermediates in the synthesis of prostaglandin E 2 . The invention still further relates to synthetic analogs and known metabolites of prostaglandin E 2 and prostaglandin E 1 , useful as standards in certain biological assays for determining prostaglandin-like activity.

专利号:US-3962291-A
优先权日:1974-09-05
标 题:Total synthesis of 11-alkyl steroids
发明人：GARLAND ROBERT B; PAPPO RAPHAEL
权利人:SEARLE & CO
摘要:A novel total synthesis of 11-alkyl steroids, utilizing readily available and inexpensive raw materials, is described. The resulting products are useful and novel pharmacological agents possessing, for example, selective hormonal properties.

专利号:US-3822254-A
优先权日:1973-05-21
标 题 :Synthesis of 25-hydroxycholesterol
发明人：PARTRIDGE J; USKOKOVIC M
权利人:HOFFMANN LA ROCHE
摘要:25-HYDROXYCHOLESTEROL, AN INTERMEDIATE IN THE PREPARATION OF BIOLOGICALLY IMPORTANT METABOLITES OF VITAMIN D3 IS SYNTHESIZED IN A MULTI-STEP PROCESS FROM STIGMASTEROL.

专利号:US-3919253-A
优先权日:1972-09-20
标 题:Prostaglandin E{HD 1 {B intermediate, 2a-carboxy-3a-(1-hydroxyethyl)-5-oxocyclopentaneheptanoic acid,{65 -lactone, lower alkyl, and aralkyl esters, and processes of their preparation
发明人：KUO CHAN-HWA; TAUB DAVID; WENDLER NORMAN L
权利人:MERCK & CO INC
摘要:Disclosed is a novel stereospecific synthesis of Prostaglandin E1.

专利号:US-9309215-B2
优先权日:2006-06-12
标题:Chiral intermediate, process for producing the same and its use in the manufacture of tolterodine, fesoterodine, or the active metabolite thereof
发明人：MEESE CLAUS
权利人:UCB PHARMA GMBH
摘要:The compound of formula (I): is provided. It may be produced by subjecting a compound of formula (IV) to a reduction reaction wherein R represents hydrogen, straight or branched C1-C6 alkyl. This compound is a valuable intermediate which may be used in the synthesis of fesoterodine, tolterodine, its active metabolite, and related compounds.