CAS: 142121-48-0; Tert-Butyl (1-Hydroxy-4-Methylpentan-2-yl)Carbamate

相似化合物

53448-09-2 7533-40-6 82010-31-9

上下游产品

2-tert-Butoxycarbonylamino-4-methyl-pentanoic acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester B°C-glycine (1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl (tert-butoxycarbonyl)aminoacetate bromoacetate(1R,2S,5R)-2-(1-methyl-1-phenylethyl)-5-methylcyclohexyl(tert-butoxycarbonyl)aminobromoacetateB°C-DL-Leu-OH

📜(1R,2S,5R)-2-(1-Methyl-1-Phenylethyl)-5-Methylcyclohexyl<(Tert-Butoxycarbonyl)Amino>Bromoacetate置于lithium Aluminium Tetrahydride体系中,用 乙醚 用作溶剂,化学反应 0.08H,反应生成Boc-D-亮氨醇
参考文献:N-Boc-α-氨基醇和α-氨基酸的立体选择性合成
标题:N-Boc-α-氨基醇和α-氨基酸的立体选择性合成
摘要:描述了n-Boc-α-氨基醇和α-氨基酸的立体选择性合成,向手性亲电甘氨酸当量α-溴-N-Boc-甘氨酸(-)苯基薄荷基酯中添加了格氏试剂.
Doi:10.1016/s0040-4039(00)80272-5

专利信息

专利号:US-2009156828-A1
优先权日:2005-12-21
标题:Novel Compounds and Methods for Forming Taxanes and Using the Same
发明人：HENRI JOHN T; MCCHESNEY JAMES D; VENKATARAMAN SYLESH; SUMNER CHRISTIAN; YIANNIKOUROS GEORGE PETROS; STEMPHOSKI AARON MICHAEL; WALKER DONALD G
权利人:TAPESTRY PHARMACEUTICALS INC
摘要:The present invention is broadly directed to novel compounds useful for the synthesis of biologically active compounds. More particularly, the present embodiments disclosed herein relate to novel side chains, that when coupled to a taxane, are useful for the synthesis of pharmaceutically useful taxanes. Methods of forming the novel side chains and coupling them to hindered alcohols, namely taxanes resulting in useful esters are also disclosed. Various taxanes compounds are known to exhibit anti-tumor activity.