专利号:US-6987186-B2 优先权日:2003-01-28 标 题 :Synthesis of small particle size quinacridone of beta crystal phase 发明人:COLE DAMIEN THURBER; JEGANATHAN SURULIAPPA GOWDER; HE YINGXIA 权利人:CIBA SC HOLDING AG 摘要:The present invention relates to a process for the synthesis of beta-quinacridone by oxidation in the presence of selected additives that promote the formation of the desired crystal phase and particle size.
专利号:US-5457203-A 优先权日:1993-09-15 标 题:Pigmentary synthesis of quinacridone solid solutions 发明人:HENDI SHIVAKUMAR B; JAFFE EDWARD E 权利人:CIBA GEIGY CORP 摘要:A general method for the direct preparation of pigmentary quinacridone solid solutions is disclosed. The disclosed process comprises oxidizing a mixture of dihydroquinacridones directly to a pigmentary quinacridone solid solution wherein the oxidation is carried out by heating a reaction mixture comprising the dihydroquinacridone mixture, an alkali metal hydroxide, a water miscible organic solvent, water and effective mounts of an oxidizing agent and a particle growth inhibitor. In addition, an analogous process useful for the direct pigmentary synthesis of α-quinacridone is disclosed. The pigments prepared by the disclosed processes do not require additional particle-size reducing after treatments in order to be useful as pigments.
专利号:US-4133828-A 优先权日:1975-08-28 标题:Manufacture of dimethylaminobenzenesulfonates 发明人:SCHEUERMANN HORST; HOCH HELMUT 权利人:BASF AG 摘要:Dimethylaminobenzenesulfonates are manufactured by reacting nitrobenzenesulfonates with formaldehyde and hydrogen in the presence of a hydrogenation catalyst containing a metal of atomic number from 24 to 29 and of phosphoric acid and water at a pH of from 2 to 3.5, at from 50 to 150° C, under a pressure of at least 40 bars, with a residence time of from 1 to 15 minutes. The products are starting materials for the synthesis of dyes, especially of rhodamine dyes, oxazine dyes and reactive dyes, and also of pharmaceuticals and pesticides.
专利号:US-RE45612-E 优先权日:2001-05-04 标 题 :Corrosion inhibitor composition applicable for aluminum and steel protection and procedure 发明人:SINKO JOHN 权利人:SINKO JOHN; MD FIFTH WARD PROPERTIES INC 摘要:A corrosion-inhibiting composition for application to a metal substrate, such as aluminum or steel, and in connection with a paint, and the synthesis of the composition. The active inhibitor constituent of the composition can be selected from the group consisting of 2,5-dimercapto-1,3,4 thiadiazole (DMTD), 2,4-dimercapto-s-triazolo-[4,3-b]-1,3-4-thiadiazole, trithiocyanuric acid (TMT), and derivatives of DMTD and TMT, including various N— or S— and N, N—, S— and N—,S-substituted derivatives of DMTD, including salts of DMTD of the general formula: M(DMTD) n , where n=1,2 or 3, and M is a metal cation and preferably M=Zn(II), Bi(III), Co(II), Ni(II), Cd(II), Pb(II), Ag(I), Sb(III), Cu(II), Li(I), Ca(II), Sr(II), Mg(II), La(III), Ce(III), Pr(III), Al(III) or Zr(IV). DMTD, TMT, and their derivatives may also be combined with phosphates, molybdates, borates, silicates, tungstates, phosphotungstates, phosphomolybdates, cyanamides, carbonates, SiO 2 and mixtures thereof.
专利号:US-2004229057-A1 优先权日:2003-01-28 标 题 :Synthesis of small particle size quinacridone of beta crystal phase
专利号:US-2016038528-A1 优先权日:2013-03-15 标 题:Rapidly Adaptable Nano Therapeutics for Treatment of Infectious Disease 发明人:MALONE BRETT; BRYSON JOSHUA 权利人:TECHULON INC 摘要:The invention relates to rapidly adaptable nanotherapeutics. The therapeutics are nucleic acid molecules, such as, RNA, DNA, or modified-DNA. The nucleic acid therapeutics are preferably administered as a nanoparticle composition, further containing one or more synthetic polymers. The therapeutics are rapidly adaptable because the identification and design of the polynucleotide sequence containing the therapeutic sequence is based upon rapid computer-implemented bioinformatics and nucleic acid synthesis protocols. The rapid adaptable protocols differ from traditional methods of antibiotic and antipathogenic drug development, which are slow and do not address drug resistance issues. Furthermore, the invention encompasses a facility with dedicated apparatus for practicing the invention in military theater or where emerging pathogenic threats are located. This facility may be mobile and transportable as a dedicated unit.
[参考文献]: Dwight Macdonald, Et Al. Discovery Of A Substituted 8-Arylquinoline Series Of Pde4 Inhibitors: Structure-Activity Relationship, Optimization, And Identification Of A Highly Potent, Well Tolerated, Pde4 Inhibitor. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5241-6. [参考文献]: Hao Xu, Et Al. Asymmetric Cooperative Catalysis Of Strong Brnsted Acid-Promoted Reactions Using Chiral Ureas. Science. 2010 Feb 19;327(5968):986-90. [参考文献]: Nichina Gomi, Et Al. Degradation Of The Synthetic Dye Amaranth By The Fungus Bjerkandera Adusta Dec 1: Inference Of The Degradation Pathway From An Analysis Of Decolorized Products. Biodegradation. 2011 Nov;22(6):1239-45. [参考文献]: Wenyi Zheng, Et Al. Fabrication Of Biocompatible And Tumor-Targeting Hyaluronan Nanospheres By A Modified Desolvation Method. J Pharm Sci. 2014 May;103(5):1529-37.
合成参考文献
摘要:Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku, Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972, -(179), 1972 摘要:S13 | EUCOSMETICS | Combined Inventory of Ingredients Employed in Cosmetic Products (2000) and Revised Inventory (2006) | DOI:10.5281/zenodo.2624118 摘要:Journal of the American College of Toxicology 15(4):337-347, 1996