CAS: 118974-02-0; Fumitremorgin C

上下游产品

(1S,3S)-7-Methoxy-1-(2-methyl-propenyl)-2-[(S)-1-(2,2,2-trichloro-ethoxycarbonyl)-pyrrolidine-2-carbonyl]-2,3,4,9-tetrahydro-1H-β-carboline-3-carboxylic acid methyl ester -piperazino--β-carboline-(5aHα, 8Hα, 14aHα)-1,6-dione8-(2'-hydroxy-2'-methylpropyl)-7,8,14,14a-tetrahydro-pyrrolidino-1,2-c-piperazino-1',6'-2,3-β-carboline-(5aHα, 8Hα, 14aHα)-1,6-dione N-2,2,2-trichloroethoxycarbonyl-L-prolinyl chloride -β-carboline2,2-dimethyl-5-(ethoxycarbonyl)-9-methoxy-4,5,6,11b-tetrahydro-isoxazolidin2,3-a-β-carboline

📜Ethyl 1-(2-Hydroxy-2-Methylpropyl)-7-Methoxy-2-((S)-1-((2,2,2-Trichloroethoxy)Carbonyl)Pyrrolidine-2-Carbonyl)-2,3,4,9-Tetrahydro-1H-Pyrido[3,4-B]Indole-3-Carboxylate置于氯化亚砜,1,8-二氮杂双环[5.4.0]十一碳-7-烯,锌体系中,用 氯仿 用作溶剂,化学反应 48.0H,反应生成烟曲酶毒素 C
参考文献:(-)-Fumitremorgin C的第一个全合成
标题:(-)-Fumitremorgin C的第一个全合成
摘要:介绍了使用6-甲氧基-N-羟基色氨酸(5A)的震颤性呋喃菌素c(1A)的第一个全合成.我们的方法的特征是形成硝酮(6A),立体选择性环加成生成7A,开环并与l-脯氨酸衍生物偶合以形成14.碱催化的差向异构化得到16,通过脱保护胺将其转化为标题化合物功能,二氧哌嗪的形成和脱水.
Doi:10.1016/s0040-4020(01)90342-4

专利信息

专利号:US-9394264-B2
优先权日:2009-11-13
标 题:Sphingosine 1 phosphate receptor modulators and methods of chiral synthesis
发明人：MARTINBOROUGH ESTHER; BOEHM MARCUS F; YEAGER ADAM RICHARD; TAMIYA JUNKO; HUANG LIMING; BRAHMACHARY ENUGURTHI; MOORJANI MANISHA
权利人:RECEPTOS INC
摘要:Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such compounds are provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated.

专利号:WO-2007141253-A1
优先权日:2006-06-07
标 题 :Process for the production of intermediates for the preparation of tricyclic imidazopyridines
发明人：PALMER ANDREAS; BUHR WILM; ZIMMERMANN PETER JAN; BREHM CHRISTOF; CHIESA MARIA VITTORIA; ZANOTTI-GEROSA ANTONIO
权利人:NYCOMED GMBH; PALMER ANDREAS; BUHR WILM; ZIMMERMANN PETER JAN; BREHM CHRISTOF; CHIESA MARIA VITTORIA; ZANOTTI-GEROSA ANTONIO
摘要:The invention relates to a process for the synthesis of compounds of the formula (1-a) and compounds of the formula (1-b). The compounds of the formula 1-a and the compounds of the formula 1-b, in which the substituents R1, R2, R3, and Arom have the meanings indicated in the description, are valuable intermediates for the preparation of pharmaceutically active compounds.

专利号:US-9156840-B2
优先权日:2010-06-18
标题:D2 antagonists, methods of synthesis and methods of use
发明人：LUEHR GARY W; SUNDARAM ARATHI; JAISHANKAR PRIYADARSHINI; PAYNE PHILIP W; DRUZGALA PASCAL
权利人:ALTOS THERAPEUTICS LLC
摘要:Provided are D 2 or D 3 antagonist compounds and pharmaceutical compositions of formula I n nand pharmaceutically acceptable salts thereof, or isomers thereof, wherein R 1 , R 2 and R 3 are as defined herein. The invention further comprises methods for making the compounds of the invention and methods for the treatment of conditions mediated by the dopamine D 2 or D 3 receptor from the compounds of the invention.

专利号:US-2008280933-A1
优先权日:2006-07-25
标 题:Benzimidazolyl compounds
发明人：EFREMOV IVAN; ROGERS BRUCE N; DUPLANTIER ALLEN J; ZHANG LEI; ZHANG QIAN; MAKLAD NOHA S; EVRARD EDELWEISS; BRODNEY MICHAEL A
权利人:EFREMOV IVAN; ROGERS BRUCE N; DUPLANTIER ALLEN J; ZHANG LEI; ZHANG QIAN; MAKLAD NOHA S; EVRARD EDELWEISS; BRODNEY MICHAEL A
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I n n n n n n n n n n as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:US-8691836-B2
优先权日:2010-06-18
标题 :D2 antagonists, methods of synthesis and methods of use

专利号:CA-2802188-A1
优先权日:2010-06-18
标题:D2 antagonists, methods of synthesis and methods of use