CAS: 878757-08-5; (R)-N,N-Dimethyl-3-(Naphthalen-1-Yloxy)-3-(Thiophen-2-yl)Propan-1-Amine

英文名称(R)-N,N-Dimethyl-3-(Naphthalen-1-Yloxy)-3-(Thiophen-2-yl)Propan-1-Amine
中文名称度洛西汀N-甲基(R)-异构体
IUPAC名称(R)-N,N-dimethyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine
其它别名(R)-N,N-Dimethyl-3-(Naphthalen-1-Yloxy)-3-(Thiophen-2-yl)Propan-1-Amine; Duloxetine Impurity 14; Duloxetine Impurity 8/(R)-N,N-Dimethyl-3-(Naphthalen-1-Yloxy)-3-(Thiophen-2-yl)Propan-1-Amine; Duloxetine-10; 2-Thiophenepropanamine, N,N-Dimethyl-γ-(1-Naphthalenyloxy)-, (γr)-; Duloxetine Impurity56; (R)-N,N-Dimethyl-3-(Naphthalen-1-Yloxy)-3-(Thiophen-2-yl)Propan-1-Amine (Duloxetine Impurity）
CAS编号878757-08-5
MFCD编号:MFCD34472966
EINECS号:603-566-2
分子式:C19H21NOS分子量:311.45
产品CID: 1887728

相似结构搜索
InChIKey: JFTURWWGPMTABQ-GOSISDBHSA-N
InChI=1S/C19H21NOS/c1-20(2)13-12-18(19-11-6-14-22-19)21-17-10-5-8-15-7-3-4-9-16(15)17/h3-11,14,18H,12-13H2,1-2H3/t18-/m1/s1
计算化学: 氢键受体数*氢键供体数*可旋转键数*

MSDS等安全信息

上下游产品

N,N-dimethyl-3-(1-naphthalenyloxy)-3-(thien-2-yl)propanamine oxalate N,N-dimethylamino-3-(1-naphthanyloxy)-3-(2-thienyl)-1-propanamine 1-Fluoronaphthalene (S)-3-dimethylamino-1-(2-thienyl)propan-1-ol (R)-Duloxetine N,N-dimethylamino-3-(1-naphthanyloxy)-3-(2-thienyl)-1-propanamine (R)-(-)-N-methyl-3-(1-napthalenyloxy)-3-(2-thienyl)propanamine hydr°Chloride (R)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine oxalate

合成工艺路线路线简述

116539-60-7 = 878757-08-5
反应条件:1.1 Reagents: Sodium Carbonate Catalysts: Iron Solvents: Dimethyl Sulfoxide,Water; 24 H,130 °C
标题:Convenient Iron-Catalyzed Reductive Aminations Without Hydrogen For Selective Synthesis Of N-Methylamines
作者:Natte,Kishore; Et Al
参考文献:Nature Communications 日期:2017 卷标:8(1) 页码:1-9]

132335-44-5 + 321-38-0 = 878757-08-5 + 132335-46-7
反应条件:1.1 Reagents: Sodium Hydride Solvents: Sulfolane; Rt -> 80 °C; 1 H,80 °C1.2 80 °C -> 100 °C; 16 H,100 °C; 100 °C -> 5 °C1.3 Reagents: Hydrochloric Acid Solvents: Toluene,Water; 10 Min,5 °C1.4 Reagents: Hydrochloric Acid Solvents: Water; Ph 2 - 2.31.5 Reagents: Sodium Hydroxide; Ph 11
标题:An Improved Process For The Preparation Of (S)-(+)-N-Methyl-3-(1-Naphthalenyloxy)-3-(2-Thenyl)Propanamine And Its Intermediate
作者:Anonymous
参考文献:Ip.Com Journal 日期:2008 卷标:8