CAS: 83635-12-5; Butyl Cyclopropanesulfonate

该化合物是一种有机硫化合物,其特点是环丙烷磺酸酯结构,该化学品具有作为烷基制剂的稳定性和再活性,因此具有价值,在有机合成和制药应用中有用.丁基混合物会提高有机溶剂的溶性,促进其在各种反应条件下的使用.其环丙烷会有助于产生生命和电子效应,促成选择性变异.磺酸酯的功能允许高效的核细胞替代反应,为构建复杂的分子框架提供多种用途.适用于受控的烷基化过程,通常用于精细的化学和中间合成.建议妥善处理和储存,因为其反应性质.

英文名称Butyl Cyclopropanesulfonate
中文名称环丙烷磺酸丁酯
IUPAC名称butyl cyclopropanesulfonate
其它别名环丙磺酸丁酯
CAS编号83635-12-5
MFCD编号:MFCD09261379
分子式:C7H14O3S
分子量:178.25
产品CID: 1824714
产品分类有机原料→分子砌块→脂肪环类化合物→环丙烷类化合物

相似结构搜索
InChIKey: VWGWOTXVWXTFMB-UHFFFAOYSA-N
InChI=1S/C7H14O3S/c1-2-3-6-10-11(8,9)7-4-5-7/h7H,2-6H2,1H3…
计算化学: 氢键受体数3.0氢键供体数0.0可旋转键数5.0

相似化合物

2095432-70-3 146475-51-6 923032-56-8

物理性质

闪点132.9±18.2°C
密度1.167g/ cm3
PSA:43.37
LogP:1.2953
蒸汽压0.003 mmHg at 25 °C
溶解性Chloroform, Dichloromethane, Ethyl Acetate
外观形态无色油状物
储存条件密封, 常温干燥保存

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H302-H315-H319-H335
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

上下游产品

1-butyl 3-chloro-1-propanesulfonate butyl 3-(dimethylamino)propanesulfonate cyclopropanesulfonyl chloride butan-1-olbutyl 1-((benzyloxy)methyl)cyclopropane-1-sulfonate

合成工艺路线路线简述

83634-86-0 = 83635-12-5
反应条件:1.1 Catalysts: Fluorosulfuric Acid,Methyl Ester2.1 Catalysts: Butyllithium
标题:Betylates. 3. Preparative Nucleophilic Substitution By Way Of [2]-,[3]-,And [4]Betylates. Stoichiometric Phase Transfer And Substrate-Reagent Ion-Pair (Srip) Reactions Of Betylates
作者:King,J. F.; Et Al
参考文献:Journal Of The American Chemical Society 日期:1982 卷标:104(25) 页码:7108-22]

15181-47-2 = 83635-12-5
反应条件:1.1 Catalysts: Butyllithium
标题:Betylates. 3. Preparative Nucleophilic Substitution By Way Of [2]-,[3]-,And [4]Betylates. Stoichiometric Phase Transfer And Substrate-Reagent Ion-Pair (Srip) Reactions Of Betylates
作者:King,J. F.; Et Al
参考文献:Journal Of The American Chemical Society 日期:1982 卷标:104(25) 页码:7108-22]

71-36-3 + 15181-47-2 = 83635-12-5
反应条件:1.1 -2.1 Catalysts: Fluorosulfuric Acid,Methyl Ester3.1 Catalysts: Butyllithium
标题:Betylates. 3. Preparative Nucleophilic Substitution By Way Of [2]-,[3]-,And [4]Betylates. Stoichiometric Phase Transfer And Substrate-Reagent Ion-Pair (Srip) Reactions Of Betylates
作者:King,J. F.; Et Al
参考文献:Journal Of The American Chemical Society 日期:1982 卷标:104(25) 页码:7108-22

Butyl 3-(Dimethylamino)Propanesulfonate置于正丁基锂体系中,用四氢呋喃,二氯甲烷作为反应溶剂,化学反应 3.0H,反应生成环丙烷磺酸丁酯
参考文献:Betylates. 3. Preparative Nucleophilic Substitution By Way Of [2]-,[3]-,And [4]Betylates. Stoichiometric Phase Transfer And Substrate-Reagent Ion-Pair (Srip) Reactions Of Betylates
标题:Betylates. 3. Preparative Nucleophilic Substitution By Way Of [2]-,[3]-,And [4]Betylates. Stoichiometric Phase Transfer And Substrate-Reagent Ion-Pair (Srip) Reactions Of Betylates
摘要:
DOI:10.1021/ja00389A038

海关参考信息

2905121000-正丙醇
2905130000-正丁醇
2904100000-仅含磺基的衍生物及其盐和乙酯
2901100000-饱和无环烃
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-9328066-B2
优先权日:2011-05-27
标题 :Chiral synthesis of N-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-methoxyphenyl}-1-[2,3-dihydroxy-propyl]cyclopropanesulfonamides
发明人：FEY PETER; MAYER AGATHE CHRISTINE
权利人:FEY PETER; MAYER AGATHE CHRISTINE; BAYER IP GMBH
摘要:The present invention relates to a novel enantioselective method of preparing (S)- and (R)-enantiomers of N-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-5 methoxyphenyl}-1-[2,3-dihydroxy-propyl]cyclopropanesulfonamide, to novel intermediate compounds, and to the use of said novel intermediate compounds for the preparation of said (S)- and (R)-enantiomers of N-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-methoxyphenyl}-1-[2,3-dihydroxy-propyl]cyclopropanesulfonamide.

专利号:ES-2682247-T3
优先权日:2011-05-27
标题 :Chiral synthesis of N- {3,4-difluoro-2 - [(2-fluoro-4-iodophenyl) amino] -6-methoxyphenyl} -1- [2,3-dihydroxy-propyl] cyclopropanesulfonamides

专利号:CA-2837162-A1
优先权日:2011-05-27
标题:Chiral synthesis of n-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-methoxyphenyl}-1-[2,3-dihydroxy-propyl]cyclopropanesulfonamides

专利号:EP-2714652-A1
优先权日:2011-05-27
标题:Chiral synthesis of n-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-methoxyphenyl}-1-[2,3-dihydroxy-propyl]cyclopropanesulfonamides

专利号:US-2014155637-A1
优先权日:2011-05-27
标题 :Chiral synthesis of n--1-[2,3-dihydroxy-propyl]cyclopropanesulfonamides

专利号:IL-228911-A
优先权日:2011-05-27
标题:Cyralic synthesis of} -n-4,3-diplooro-2 [(2-fluoro-4-iodophenyl) amino] -6-methoxyphenyl} -1- [3,2-dihydroxy-profile] cyclopropanesulfonamides