CAS: 78471-43-9; Methyl 4-Bromo-2-Bromomethylbenzoate

上下游产品

4-溴-2-甲基苯甲酸甲酯 4-Bromo-2-Methyl-Benzoic Acid Methyl Ester 99548-55-7
4-溴-2-甲基苯甲酸 4-Bromo-2-Methylbenzoic Acid 68837-59-2

4-溴-2-甲基苯甲酸置于n-溴代丁二酰亚胺(Nbs),偶氮二异丁腈体系中,用 四氯化碳 作为反应溶剂,化学反应生成 4-溴-2-溴甲基苯甲酸甲酯
参考文献:推出 Fm-1088:异吲哚酮类杀螨剂开发的突破
标题:推出 Fm-1088:异吲哚酮类杀螨剂开发的突破
摘要:农业害虫对现有杀螨剂的抗药性不断增强,对可持续农业提出了重大挑战.因此,本研究引入了fm-1088,这是一种新型异吲哚啉酮基苯基三氟乙基硫醚衍生物,通过结合生物电子等排作用和新颖环化方法的创新设计策略反应生成.我们合成了几种化合物,并评估了它们对温室中朱砂叶螨和田间柑橘全爪螨的杀螨功效. Fm-1088成为出色的候选药物,与商业杀螨剂 Cyetpyrafen 相比,其中位致死浓度 (Lc 50) 较低,为 0.722 Mg/l.值得注意的是,施用 30 天后,Fm-1088对柑橘疫病菌的田间防效高达 96.4%,凸显了其更广泛应用的潜力.研究结果强调了异吲哚酮支架在农药开发中的实用性,为对抗害虫抗性提供了一种有前景的解决方案,对增强作物保护和农业生产力具有重要意义.未来的研究应探索fm-1088的详细作用模式及其在不同农业环境中的潜在适用性,进一步确认其作为害虫管理可持续解决方案的作用.
DOI:10.1021/acs.Jafc.4C05027

专利信息

专利号:US-10112955-B2
优先权日:2015-10-29
标题 :Isoindoline, azaisoindoline, dihydroindenone and dihydroazaindenone inhibitors of Mnk1 and Mnk2
发明人：SPRENGELER PAUL A; REICH SIEGFRIED H; ERNST JUSTIN T; WEBBER STEPHEN E; SHAGHAFI MIKE; MURPHY DOUGLAS; TRAN CHINH
权利人:EFFECTOR THERAPEUTICS INC
摘要:The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof. n nFor Formula I compounds A 1 , A 2 , A 3 , A 4 , A 5 , W 1 , Y, R 1 , R 2 , R 3 , R 4 , R 5 , R 6a , R 6b , R 7 , R 8 , R 8a , R 8b , R 9 , R 9a , R 9b , and R 10 and subscript “nâ€? are as defined in the specification. The inventive Formula I compounds are inhibitors of Mnk and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.

专利号:US-9856241-B2
优先权日:2013-07-03
标 题:Substituted benzofuranyl and benzoxazolyl compounds and uses thereof
发明人：BALOGLU ERKAN; SHACHAM SHARON; SENAPEDIS WILLIAM; MCCAULEY DILARA; LANDESMAN YOSEF; GOLAN GALI; KALID ORI; SHECHTER SHARON
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to substituted benzofuranyl and substituted benzoxazolyl compounds, and more particularly to a compound represented by Structural Formula (A): or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of Structural Formula (A), or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders.

专利号:CN-111170991-B
优先权日:2014-07-11
标题 :Antiproliferative compounds and methods of synthesis thereof

专利号:CN-111170991-A
优先权日:2014-07-11
标 题:Antiproliferative compounds and methods of synthesis thereof

专利号:US-2011212078-A1
优先权日:2008-06-25
标 题:Synthesis and use of heterocyclic antibacterial agents