CAS: 7361-31-1; Methyl 2-Amino-3-(4-Hydroxyphenyl)-2-Methylpropanoate Hydrochloride
该化合物是一种化学化合物,是合成各种药物和生物化学研究的重要中间体,是氨基酸乙基乙酰胺的衍生物,经专门修改后,包括甲型和酯功能组的甲基组,该化合物一般是白色的脱白晶粉,在水和有机溶剂中溶解,因此在各种实验室应用中有用.盐的盐质形式增强了其稳定性和溶解性. -甲基甲基盐酸乙酯因其作为酶聚苯乙酰胺抑制剂的作用而著称,该抑制剂在乙酸酚胺的生物合成中至关重要,这种抑制作用在与...
- 英文名称Methyl 2-Amino-3-(4-Hydroxyphenyl)-2-Methylpropanoate Hydrochloride
- 中文名称Α-甲基-DL-酪氨酸甲酯盐酸盐
- IUPAC名称methyl (2S)-2-amino-3-(4-hydroxyphenyl)-2-methylpropanoate;methyl (2R)-2-amino-3-(4-hydroxyphenyl)-2-methylpropanoate;dihydrochloride
- 其它别名DL-Tyrosine,a-methyl-, methyl ester,hydr°Chloride; Tyrosine, a-methyl-, methyl ester, hydr°Chloride (9CI); Tyrosine, a-methyl-, methyl ester,hydr°Chloride, DL- (8CI); (dl)-a-Methyl-p-tyrosine methyl ester hydr°Chloride; (?à)-a-Methyl-p-tyrosine methyl ester hydr°Chloride; DL-a-Methyl-p-tyrosine methyl esterhydr°Chloride; DL-a-Methyltyrosine methyl ester hydr°Chloride; H 44/68; Methyl DL-a-methyltyrosine hydr°Chloride; a-Methyl-p-tyrosinemethyl ester hydr°Chloride; a-Methyltyrosine methyl ester hydr°Chloride
- CAS编号7361-31-1
- MFCD编号:MFCD00012606
- EINECS号:230-900-0
- 分子式:C11H15NO3.ClH分子量:245.7
- 产品CID: 1723320
- 产品分类有机原料→生命科学→氨基酸及其衍生物→酪氨酸及其衍生物
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专利信息
专利号:US-2014309424-A1
优先权日:2011-06-30
标题:Direct synthesis of 18f-fluoromethoxy compounds for pet imaging and the provision of new precursors for direct radiosynthesis of protected derivatives of o-([18f] fluoromethyl) tyrosine
发明人：BRUMBY THOMAS; GRAHAM KEITH; KRUGER MARTIN
权利人:BRUMBY THOMAS; GRAHAM KEITH; KRUGER MARTIN; PIRAMAL IMAGING SA
摘要:The invention describes novel direct synthesis methods for converting a precursor into a PET-tracer with a 18 F-fluoromethoxy-group. The invention is also directed to novel and stable precursors for the direct radiosynthesis of protected derivatives of O—([ 18 F]Fluoromethyl)tyrosines.
专利号:WO-2013001088-A1
优先权日:2011-06-30
标 题 :Direct synthesis of 18f-fluoromethoxy compounds for pet imaging and the provision of new precursors for direct radiosynthesis of protected derivatives of o-([18f]fluoromethyl) tyrosine
专利号:EP-2751087-A1
优先权日:2011-06-30
标题 :Direct synthesis of 18f-fluoromethoxy compounds for pet imaging and the provision of new precursors for direct radiosynthesis of protected derivatives of o-([18f]fluoromethyl)tyrosine
专利号:CN-103857660-A
优先权日:2011-06-30
标 题:For PET imaging18Direct synthesis of F-fluoromethoxy compounds and use thereof in direct radiosynthesis of O- ([ 2 ]18F]Novel precursors of protected derivatives of fluoromethyl) tyrosine
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主要参考文献
[参考文献]: G Magnusson, Et Al. Renal Lesions Induced By Alpha-Methyltyrosine Methylester And Alpha-Methyltyrosine. Acta Pharmacol Toxicol (Copenh). 1970;28(6):435-44.[参考文献]: A Lu, Et Al. Conditional Mouse Mutants Highlight Mechanisms Of Corticotropin-Releasing Hormone Effects On Stress-Coping Behavior. Mol Psychiatry. 2008 Nov;13(11):1028-42.
[参考文献]: Alexander Kuzmin, Et Al. Evidence In Locomotion Test For The Functional Heterogeneity Of Orl-1 Receptors. Br J Pharmacol. 2004 Jan;141(1):132-40.
[参考文献]: C Miguelez, Et Al. Alpha(2)-Adrenoceptors Mediate The Acute Inhibitory Effect Of Fluoxetine On Locus Coeruleus Noradrenergic Neurons. Neuropharmacology. 2009 May-Jun;56(6-7):1068-73.
[参考文献]: J M Pequignot, Et Al. Transection Of Carotid Sinus Nerve Inhibits The Turnover Of Dopamine And Norepinephrine In Long-Term Hypoxic Carotid Bodies: A Biochemical And Morphometric Study. J Auton Nerv Syst. 1991 Feb;32(2):165-76.
合成参考文献
摘要:Toxicology and Applied Pharmacology., 28(227), 1974 []
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