CAS: 5714-73-8; 1,3,5,7-Tetraazaadamantane Benzoylglycinate

该化合物是一种化学化合物,主要用作尿道抗腐蚀剂;一种在水中溶解的白色脱白晶状粉,适合用于各种药物配方;该化合物由三氯胺胺酸和潮纯酸反应形成,有助于其治疗性能;众所周知,甲基氨丙酸能够释放酸尿中的甲醛,对一系列病原体,特别是尿道的病原体产生抗微生物效应;这一特征有助于治疗和预防尿道感染;此外,该物质一般都具有良好的耐受性,尽管有些人可能受到胃肠扰动等副作用;其使用往往伴有适当的水分,以确保有效的排泄和尽量减少潜在毒性;

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

合成工艺路线路线简述

    📜马尿酸,乌洛托品 以 正庚烷,水 作为反应溶剂,化学反应 4.0H,以95.9%的收率获得产物马尿酸乌洛托品
    参考文献:一种马尿酸乌洛托品的合成方法
    标题:一种马尿酸乌洛托品的合成方法
    摘要:本发明公开了一种马尿酸乌洛托品的合成方法,马尿酸和乌洛托品在乙酸乙酯,正庚烷等惰性溶剂中,在少量水诱发下,快速搅拌下进行固固反应反应生成马尿酸乌洛托品盐,过滤,干燥.本发明简化了操作步骤,提高了收率.

    海关参考信息

    专利信息


    专利号:US-9693999-B2
    优先权日:2011-01-26
    标题:Small molecule RNase inhibitors and methods of use
    发明人:DUNMAN PAUL M; OLSON PATRICK D; CHILDERS WAYNE
    权利人:UNIV ROCHESTER; UNIV NEBRASKA; Temple University—Of the Commonwealth System of Higher Education
    摘要:Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing microbial infections and inhibiting bacterial ribonuclease. Also described herein are methods of identifying compounds for treating or preventing a microbial infection.

    专利号:WO-2009056955-A1
    优先权日:2007-10-30
    标题 :Amine-bearing phospholipids (abps), their synthesis and use
    发明人:ZUMBUEHL ANDREAS
    权利人:UNIV BASEL; ZUMBUEHL ANDREAS
    摘要:Disclosed herein are amine-bearing phospholipids (ABP). The ABPs display many properties and functionalities of naturally occurring phospholipids, but also new properties and functionalities, such as the ability to polymerize while maintaining structural integrity, that may supplement or expand the functionalities of naturally occurring phospholipids.

    专利号:US-9868747-B2
    优先权日:2014-02-18
    标题:Marinopyrrole derivatives and methods of making and using same
    发明人:LI RONGSHI; SEBTI SAID; LIU YAN; QIN YONG; SONG HAO; CHENG CHUNWEI
    权利人:H LEE MOFFITT CANCER CT & RES; CHONGQING ZEIN PHARMACEUTICAL CO LTD
    摘要:Marinopyrrole derivatives and methods for their synthesis and use are described herein. Novel cyclic and symmetric marinopyrroles with triazole substituents having antibacterial activity against resistant bacterial strains, such as MRSA are introduced. Also provided are methods of using the compounds for treating or preventing cancer and/or microbial infections.

    专利号:US-9907753-B2
    优先权日:2010-03-19
    标 题 :Lipid vesicle compositions and methods of use
    发明人:IRVINE DARRELL J; MOON JAEHYUN
    权利人:MASSACHUSETTS INST TECHNOLOGY
    摘要:The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles may comprise prophylactic, therapeutic and/or diagnostic agents.

    专利号:US-2013164265-A1
    优先权日:2011-12-21
    标题 :Skin care compositions
    发明人:FLAVIN DANA; OBENLAND SIGRID
    权利人:FLAVIN DANA; OBENLAND SIGRID
    摘要:This invention provides compositions and methods of manufacturing such compositions that employ GRAS compounds which can act to promote the generation of stem, epidermal or other skin cells in the epidermis, activation of collagen synthesis, activation of hyaluronic acid synthesis, enhanced skin hydration, and dermal healing by stimulating stem cell and fibroblast migration to sites of needed repair. These compositions and methods are useful for rejuvenating the skin and for treating some skin-related aging or other dermal damaging conditions, including wrinkle reduction and treatment of minor dermal wounds.

    专利号:US-2014328952-A1
    优先权日:2011-12-21
    标题:Topical compositions
    发明人:FLAVIN DANA
    权利人:FLAVIN DANA
    摘要:This invention provides compositions and methods of manufacturing such compositions that employ GRAS compounds which can act to promote the generation of stem, epidermal or other skin cells in the epidermis, activation of collagen synthesis, activation of hyaluronic acid synthesis, enhanced skin hydration, and dermal healing by stimulating stem cell and fibroblast migration to sites of needed repair. These compositions and methods are useful for rejuvenating the skin and for treating some skin-related aging or other dermal damaging conditions, including wrinkle reduction and treatment of minor dermal wounds.

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    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Barclay J, Veeratterapillay R, Harding C. Non-antibiotic options for recurrent urinary tract infections in women. BMJ. 2017 Nov 23;359:j5193. doi: 10.1136/bmj.j5193. doi: 10.1016/j.actbio.2017.08.019. Epub 2017 Aug 16. doi: 10.3760/cma.j.issn.0529-5807.2017.06.013. Chinese. doi: 10.1586/14787210.2014.904202. Epub 2014 Apr 1. Review.

    合成参考文献


    摘要:Stover SL, Fleming WC. Recurrent bacteriuria in complete spinal cord injury patients on external condom drainage. Arch Phys Med Rehabil. 1980 Apr;61(4):178–82.
    参考文献:10.1007/s00345-011-0700-5
    摘要:Yang SS, Chiang IN, Lin CD, Chang SJ. Advances in non-surgical treatments for urinary tract infections in children. World J Urol. 2012 Feb;30(1):69–75. doi: 10.1007/s00345-011-0700-5.
    参考文献:10.1007/s00345-017-2000-1
    摘要:Jung H, Andonian S, Assimos D, Averch T, Geavlete P, Kohjimoto Y, Neisius A, Philip J, Saita A, Shah H, Osther PJ. Urolithiasis: evaluation, dietary factors, and medical management: an update of the 2014 SIU-ICUD international consultation on stone disease. World J Urol. 2017 Sep;35(9):1331–40. doi: 10.1007/s00345-017-2000-1.
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