CAS: 5600-62-4; 4-(4-Nitrophenyl)Butanoic Acid

该化合物是一种硝基苯替代品的箱式酸衍生物,广泛用作有机合成和制药研究的中间体,其主要优点包括:一个定义明确的芳香硝基硝酸组,通过减少或替代反应促进进一步发挥作用,以及一个灵活的丁基酸链,增强有机溶剂的溶性.该化合物对于培养生物活性分子,消化器和材料科学应用特别宝贵.其晶体形式确保高纯度和稳定性,使之适合精确的合成工作流程.该硝基苯组还充当分析反应监测的光谱处理器.

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ECHA物质C&L通报REACH预注册

上下游产品

4-(4-氨基苯基)丁酸 4-(4-Aminophenyl)Butyric Acid 15118-60-2
4-苯基丁酸 4-Phenylbutyric Acid 1821-12-1

合成工艺路线路线简述

    📜4-苯基丁酸置于硫酸,硝酸,溶剂黄146体系中,化学反应生成 4-(4-硝基苯)丁酸
    参考文献:Fieser Et Al.,Journal Of The American Chemical Society,1948,Vol. 70,P. 3177
    标题:Fieser Et Al.,Journal Of The American Chemical Society,1948,Vol. 70,P. 3177

    海关参考信息

    专利信息


    专利号:US-5786448-A
    优先权日:1996-11-07
    标题:Combinatorial libraries of cyclic urea and cyclic thiourea derivatives and compounds therein
    发明人:NEFZI ADEL; OSTRESH JOHN M; HOUGHTEN RICHARD
    权利人:TREGA BIOSCIENCES INC
    摘要:The invention provides a rapid approach for combinatorial synthesis and screening of libraries of cyclic urea and cyclic thiourea compounds. The present invention further provides the compounds made by the combinatorial synthesis.

    专利号:US-6531470-B1
    优先权日:1998-01-23
    标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
    发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
    权利人:UPJOHN CO
    摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

    专利号:US-6562844-B2
    优先权日:1998-01-23
    标 题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
    发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
    权利人:UPJOHN CO
    摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

    专利号:US-9217012-B2
    优先权日:2009-04-08
    标题 :Inhibitors of protein tyrosine phosphatases
    发明人:ZHANG ZHONG-YIN; ZHANG SHENG
    权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP
    摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.

    专利号:EA-002100-B1
    优先权日:1996-12-23
    标题:CYCLOALCYL COMPOUNDS, LACTAMS, LACTONES AND RELATED COMPOUNDS CONTAINING THEIR PHARMACEUTICAL COMPOSITIONS AND METHODS OF INHIBITING THE SURVIVAL AND / OR SYNTHESIS OF β-AMYLOUS PEPTIDE SOFTWARE AGREED SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE, SOFTWARE AND SOFTWORK

    专利号:WO-9009446-A1
    优先权日:1989-02-17
    标 题 :Cutinase
    发明人:DE GEUS PIETER
    权利人:PLANT GENETIC SYSTEMS NV
    摘要:A pure cutinase is secreted from E. coli transformed with a DNA sequence from Fusarium solani pisi. The pure cutinase can efficiently catalyse the hydrolysis and the synthesis of esters in aqueous and non-aqueous media, both in the absence and the presence of an interface between the cutinase and the substrates.

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    ✅ COA系统入驻 | 共享模式

    合成参考文献


    摘要:Ouyang, Y.; Shou, J.-Y.; Qing, F.-L., Science of Synthesis: Special Topics, (2022) 1, 296.
    摘要:Sawamura, M.; Shimizu, Y., Science of Synthesis: Knowledge Updates, (2024) 2, 214.
    参考文献:10.1124/dmd.30.5.541
    摘要:Xie M, Yang D, Liu L, Xue B, Yan B. Human and rodent carboxylesterases: immunorelatedness, overlapping substrate specificity, differential sensitivity to serine enzyme inhibitors, and tumor-related expression. Drug Metab Dispos. 2002 May;30(5):541–7. doi: 10.1124/dmd.30.5.541.
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