1,2,4-苯三甲酸 以 N,N-二甲基乙酰胺,氯苯,甲苯 作为反应溶剂,化学反应 10.0H,以5.7 G的收率获得产物偏苯三酸酐 参考文献:Method For Producing Carboxylic Acid Anhydride,Method For Producing Carboxylic Imide,And Method For Manufacturing Electrophotographic Photosensitive Member 标题:Method For Producing Carboxylic Acid Anhydride,Method For Producing Carboxylic Imide,And Method For Manufacturing Electrophotographic Photosensitive Member 摘要:生产羧酸酐的方法包括加热含有特定化合物的溶剂中的混合物,以产生羧酸酐.该溶剂是具有沸点为50oc或更高的无水极性溶剂.
专利号:US-2004249114-A1 优先权日:2001-02-06 标题 :Methods of synthesis of polysuccinimide or polyaspartate by end capping polymerization 发明人:SWIFT GRAHAM; REDLICH GEORGE H; WEHBY JOHN NOLAN 摘要:Disclosed are methods of synthesis of homopolymers or copolymers containing succinimide or aspartate moieties formed in the presence of an end capping initiator. Also disclosed are methods of isolating, compounding, stabilizing and processing the homopolymers and copolymers.
专利号:US-2006211843-A1 优先权日:2001-02-06 标题:Methods of synthesis of poly(succinimide-aspartate) polysuccinimide or polyaspartate by end capping polymerization 发明人:SWIFT GRAHAM; REDLICH GEORGE H 权利人:SWIFT GRAHAM; REDLICH GEORGE H 摘要:Disclosed are methods of synthesis of homopolymers or copolymers containing succinimide or aspartate moieties formed in the presence of an end capping initiator. Also disclosed are methods of isolating, compounding, stabilizing and processing the homopolymers and copolymers.
专利号:US-7319155-B2 优先权日:2004-05-14 标题:7,7-disubstituted (5H,9H)-6,8-dioxabenzocycloheptene compounds useful in the synthesis of non-steroidal analogues of vitamin D 发明人:TERRANOVA ERIC; PASCAL JEAN-CLAUDE 权利人:GALDERMA RES & DEV 摘要:Novel 7,7-disubstituted (5H,9H)-6,8-dioxabenzocycloheptene compounds having the structural formula (I): n nare useful intermediates in the synthesis of non-steroidal derivatives of vitamin D.
专利号:US-2004249115-A1 优先权日:2001-02-06 标题 :Methods of synthesis of poly(succinimide-aspartate) copolymer by end-capping polymerization 发明人:SWIFT GRAHAM; REDLICH GEORGE H 摘要:Disclosed are methods of synthesis of copoly(succinimide-aspartate), copolymers and derivatives thereof, prepared in a thermal or supercritical fluid method in the presence of an end capping initiator. Also disclosed are methods of isolating, compounding, stabilizing and processing the copoly(succinimide-aspartate), and its derivatives.
专利号:US-2009131651-A1 优先权日:2003-12-05 标题 :Synthesis of 2-substituted adenosines 发明人:BROWN GILES ALBERT; SAVORY EDWARD DANIEL; OUZMAN JACQUELINE VALERIE ANNE; STODDART ALISON MARGARET 权利人:BROWN GILES ALBERT; SAVORY EDWARD DANIEL; OUZMAN JACQUELINE VALERIE ANNE; STODDART ALISON MARGARET 摘要:Synthesis of 2-substituted adenosines of formula (I) using 2-nitro pentabenzoyl adenosine, or 2-nitro pentaacetyl adenosine, as intermediate is described: Formula (I) wherein R=C 1-6 alkoxy (straight or branched), a phenoxy group (unsubstituted, or mono-, or di-substituted by halo, amino, CF 3 —, cyano, nitro, C 1-4 alkyl, or C 1-4 alkoxy), a benzyloxy group (unsubstituted, or mono-, or di-substituted by halo, amino, CF 3 —, cyano, nitro, C 1-6 alkyl, or C 1-6 alkoxy), or a benzoyl group (unsubstituted, or mono-, or di-substituted by halo, amino, CF 3 —, cyano, nitro, C 1-6 alkyl, or C 1-6 alkoxy). The methods provide improved yield and purity of product.
专利号:EP-1747213-B1 优先权日:2004-05-14 标题 :Novel 7,7-disubstituted derivatives of (5h,9h)-6,8-dioxabenzocycloheptene, preparation method thereof and use of same in the synthesis of non-steroidal vitamin d analogues 发明人:TERRANOVA ERIC; PASCAL JEAN-CLAUDE 权利人:GALDERMA RES & DEV 摘要:Optionally 7-substituted or 7,7-disubstituted 2-(formyl or substituted methyl)-(5H,9H)-6,8-dioxabenzocycloheptenes (I) are new. Dioxabenzocycloheptene derivatives of formula (I) and their optical isomers are new. A : -CH 2Y 1> or -CHO; Y 1>halo (specifically Cl or Br), OH, OSO 3R 2> or P(O)(OR 3>) 2; R, R 1>H (but preferably not both H), alkyl, alkoxy or aryl (optionally substituted by 1-5 of halo, alkyl, alkoxy, CN and/or NO 2); or R + R 1>group completing a 5-6C ring (specifically a cyclopentane or cyclohexane ring); R 2>alkyl or aryl; R 3>alkyl. Independent claims are included for: (A) the preparation of (I); (B) the synthesis of non-steroidal vitamin D analogs, specifically (3,4-bis-hydroxymethyl-phenyl)-methyl-substituted biphenyl derivatives of formula (IV), using (I) in at least one of the stages; and (C) the use of biphenyl derivatives of formula (II) for the preparation of (IV). X : CH 2, NH, NR 8> or O; R 4>, R 5>, R 8>1-3C alkyl; R 6>, R 7>Me, Et, CF 3 or C 2F 5; Z 1>OH, NHR 8>, NH 2 or CHO. [Image] [Image] ACTIVITY : None given. MECHANISM OF ACTION : None given.
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合成参考文献
参考文献:10.1155/2011/424203 摘要:Anderson SE, Siegel PD, Meade BJ. The LLNA: A Brief Review of Recent Advances and Limitations. J Allergy (Cairo). 2011;2011():424203.