CAS: 5118-07-0; 3-Hydroxythiophene-2-Carboxylic Acid

上下游产品

CAS号186588-88-5 3-苄氧基噻吩-2-羧酸 | CAS号5118-06-9 3-羟基-2-噻吩甲酸甲酯 | CAS号2158-88-5 3-羟基噻吩-2-羧酸乙酯 | CAS号62353-75-7 3-甲氧基噻吩-2-羧酸甲酯 | CAS号647834-01-3 N-benzyl-3-hydr... | CAS号918135-82-7 N-(1-ethynylcyc...

3-苄氧基噻吩-2-羧酸置于钯 氢气体系中,用 乙醇,盐酸 作为反应溶剂,化学反应 2.0H,以to Afford The Title Compound (600 Mg,98%) As An Off-White Solid的收率获得产物3-羟基噻吩-2-甲酸
参考文献:Thiophene-2-Carboxamide Derivatives As Alpha 7 Nicotinic Receptor Modulators
标题:Thiophene-2-Carboxamide Derivatives As Alpha 7 Nicotinic Receptor Modulators
摘要:公式(i)的化合物,其中e,A和r1如说明书所述,药学上可接受的盐,制备方法,含有该化合物的制药组合物以及使用该组合物的方法.

专利信息

专利号:CN-104284891-A
优先权日:2012-03-17
标 题:Conformational Restricted Total Synthesis of Macrocyclic Compounds

专利号:US-10017481-B2
优先权日:2012-03-17
标 题 :Conformationally constrained, fully synthetic macrocyclic compounds
发明人：OBRECHT DANIEL; ERMERT PHILIPP; OUMOUCH SAID; PIETTRE ARNAUD; GOSALBES JEAN-FRANÇOIS; THOMMEN MARC
权利人:POLYPHOR AG
摘要:The conformationally restricted, spatially defined macrocyclic ring system of formula (I) is constituted by three distinct molecular parts: Template A, conformation Modulator B and Bridge C. Macrocycles described by this ring system I are readily manufactured by parallel synthesis or combinatorial chemistry in solution or on solid phase. They are designed to interact with a variety of specific biological target classes, examples being agonistic or antagonistic activity on G-protein coupled receptors (GPCRs), inhibitory activity on enzymes or antimicrobial activity. In particular, these macrocycles show inhibitory activity on endothelin converting enzyme of subtype 1 (ECE-1) and/or the cysteine protease cathepsin S (CatS), and/or act as antagonists of the oxytocin (OT) receptor, thyrotropin-releasing hormone (TRH) receptor and/or leukotriene B4 (LTB4) receptor, and/or as agonists of the bombesin 3 (BB3) receptor, and/or show antimicrobial activity against at least one bacterial strain. Thus they are showing great potential as medicaments for a variety of diseases.