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CAS号5663-71-8 2-(amin°Carbony... | CAS号5538-51-2 邻乙酰水杨酰氯 | CAS号2757-23-5 氯羰基亚磺酰氯 | CAS号54789-70-7 2-methyl-1,3-be... | CAS号54789-69-4 2-methyl-1,3-be... | CAS号108-24-7 乙酸酐 | CAS号65-45-2 水杨酰胺 | CAS号75-36-5 乙酰氯 | CAS号78-39-7 原乙酸三乙酯 | CAS号20602-57-7 4H-1,3-BENZOXAZ... | CAS号65483-96-7 6-(5-methyl-2-p... | CAS号79349-23-8 2-(3-甲基-1,2,4-恶...

📜水杨酰胺置于吡啶,Titanium(Iv) Isopropylate,盐酸,Bis(1,5-Cyclooctadiene)Diiridium(I) Dichloride,氢气,C45H36F6Fen2P2S体系中,用 异丙醇 作为反应溶剂,20.0~25.0 °C,6.08 Mpa 条件下,反应 24.0H,反应生成 醋水杨胺
参考文献:阳离子中间体的不对称氢化,用于合成手性n,O-缩醛.
标题:阳离子中间体的不对称氢化,用于合成手性n,O-缩醛.
摘要:半个多世纪以来,过渡金属催化的均相加氢主要集中在中性和易于制备的不饱和底物上.尽管将分子氢加到c = C,C = N和c = O键上代表了一个经过充分研究的范例,但阳离子物种的不对称氢化仍然是一个欠发达的领域.在这项研究中,我们寻求以阳离子中间体为目标的不对称氢化方面的突破,并因此有望将此强大工具应用于具有挑战性的手性分子的构建.在酸性条件下,N-或o-乙酰水杨酰胺都进行环化反应生成阳离子中间体,随后被铱或氢化铑配合物还原.结果n,O-乙缩醛的合成具有很高的对映选择性.这种催化策略显示出高效率(周转数高达4400)和高化学选择性.机理研究支持了阳离子中间体在原位形成并随后氢化的假说.已经提出了催化循环,其中氢化物从铱配合物转移到阳离子sp 2碳原子是决定速率的步骤.已经创建了催化剂的空间图以说明手性环境,并且定量结构-选择性关系分析显示了在此化学转化中如何实现对映异构体诱导.
DOI:10.1002/chem.202002930

专利信息

专利号:US-8546532-B2
优先权日:2008-04-17
标题:Synthesis of directed sequence polymer compositions and antibodies thereof for the treatment of protein conformational disorders
发明人：BONNIN DUSTAN; ZANELLI ERIC; MATHERS THOMAS
权利人:BONNIN DUSTAN; ZANELLI ERIC; MATHERS THOMAS; DECLION PHARMACEUTICALS INC
摘要:The instant invention comprises a process for the solid phase synthesis of directed epitope peptide mixtures useful in the treatment and diagnosis of protein conformational disorders, such process defined by a set of rules regarding the identity and the frequency of occurrence of amino acids that substitute a base or native amino acid of a known epitope. The resulting composition is a mixture of related peptides for therapeutic use. The invention also pertains to the process of generating antibodies using the directed epitope peptide mixtures as the antigens, and antibodies generated by such process, useful in the treatment and diagnostics of the said protein conformational disorder.

专利号:US-4879389-A
优先权日:1986-06-25
标题:Chiral phosphinopyrrolidine compounds and their use for asymmetric synthesis of optically active compounds
发明人：ACHIWA KAZUO
权利人:ACHIWA KAZUO
摘要:New chiral phosphinopyrrolidine compounds of the general formula: (I) or (I') wherein R1 is a hydrogen atom, -COR, -COOR, -CONHR or -SO2-R where R is an alkyl or aryl group, R2 and R3 each represents independently an aryl group which may have a substituent or substituents, and R4 and R5 each represents independently an aliphatic or cycloaliphatic hydrocarbyl group which may have a substituent or substituents, as well as the use of these compounds as ligand for a metal complex catalyst for asymmetric synthesis of optically active compounds. The new chiral phosphinopyrrolidine compounds are useful ligands which attain both of high optical yield and high reaction efficiency in catalytic asymmetric reduction.

专利号:US-8202985-B2
优先权日:2005-10-31
标 题:Monomer compositions for the synthesis of polynucleotides, methods of synthesis, and methods of deprotection
发明人：DELLINGER DOUGLAS J; TIMAR ZOLTAN; SIERZCHALA AGNIESZKA; DELLINGER GERALDINO; CARUTHERS MARVIN H
权利人:DELLINGER DOUGLAS J; TIMAR ZOLTAN; SIERZCHALA AGNIESZKA; DELLINGER GERALDINO; CARUTHERS MARVIN H; AGILENT TECHNOLOGIES INC; UNIV COLORADO
摘要:Nucleotide monomers, polynucleotides, methods of making each, and methods of deprotecting each, are disclosed. An embodiment of the nucleotide monomer, among others, includes a nucleotide monomer having a heterobase protecting group selected from structures I through III as described herein. An embodiment of the polynucleotide, among others, includes a plurality of nucleotide moieties having a heterobase protecting group selected from one of structures I through III as described herein.

专利号:US-7759471-B2
优先权日:2005-10-31
标题 :Monomer compositions for the synthesis of RNA, methods of synthesis, and methods of deprotection
发明人：DELLINGER DOUGLAS J; TIMAR ZOLTAN; SIERZCHALA AGNIESZKA; DELLINGER GERALDINE; CARUTHERS MARVIN H
权利人:AGILENT TECHNOLOGIES INC; UNIV COLORADO
摘要:Nucleotide monomers, polynucleotides, methods of making each, methods of deprotecting each, and the like are disclosed herein.

专利号:US-9051302-B2
优先权日:2008-01-15
标 题 :Synthesis of resorcylic acid lactones useful as therapeutic agents
发明人：WINSSINGER NICOLAS; BARLUENGA SOFIA; KARPLUS MARTIN
权利人:WINSSINGER NICOLAS; BARLUENGA SOFIA; KARPLUS MARTIN; UNIV STRASBOURG
摘要:Disclosed are macrocyclic compounds of formulae I, I′, II, II′, III, III′, IV, and V, which are analogs of the pochonin resorcylic acid lactones, pharmaceutical compositions comprising the compounds, and methods and uses comprising the compounds for the treatment of diseases mediated by kinases and Heat Shock Protein 90 HSP90.

专利号:US-2024287041-A1
优先权日:2021-05-20
标题 :Methods of synthesis of heteroaryl derivatives of triazolyl acrylamides and crystalline forms
发明人：BALOGLU ERKAN; AUSTAD BRIAN C; ROE DAVID G; KEDUC ANDREW; GOTTSCHLING STEPHEN EDMUND; HECKER EVAN
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The present invention relates to a method of preparing a compound represented by structural formula (VII), comprising reacting a compound represented by structural formula (II), with a compound represented by structural formula (III), in a solvent, in the presence of a Pd catalyst and one or more inorganic bases under conditions suitable to prepare a compound represented by structural formula (VII): The values and example values of the variables in structural formulas (VII), (II), and (III) are defined herein. The present invention also relates to crystalline Forms I and II of the compound represented by Structural Formula (VII), the use of the crystalline Forms in treating disease or disorders associated with CRM1 and method of preparing the crystalline Forms.