CAS: 478-95-5; 6-Methyl-9,10-Didehydro-Ergoline-8-Carboxylic Acid

英文名称6-Methyl-9,10-Didehydro-Ergoline-8-Carboxylic Acid
中文名称D-异麦角酸
其它别名Ergoline-8a-carboxylic acid,9,10-didehydro-6-methyl- (8CI); Isolysergic acid (6CI,7CI); Indolo[4,3-fg]quinoline,ergoline-8-carboxylic acid deriv.; D-Isolysergic acid
CAS编号478-95-5
FDA UNII编号:27ZA71OH94
分子式:C16H16N2O2分子量:268.31
产品CID: 1474626
产品分类有机原料 → 生物碱及其衍生物 → 麦角林及其衍生物

相似结构搜索
InChIKey: ZAGRKAFMISFKIO-IINYFYTJSA-N
1S/C16H16N2O2/c1-18-8-10(16(19)20)5-12-11-3-2-4-13-15(11)9(7-17-13)6-14(12)18/h2-5,7,10,14,17H,6,8H2,1H3,(H,19,20)/t10-,14+/m0/s1
计算化学: 氢键受体数3.0氢键供体数2.0可旋转键数1.0

MSDS等安全信息

上下游产品

麦角酸 D-Lysergic Acid 82-58-6
(6Ar,9R)-7-甲基-4,6,6A,7,8,9-六氢-吲哚并[4,3-Fg]喹啉-9-甲酰肼 (+/-)-Isolysergic Acid Hydrazide 5256-60-0
(+)-9,10-Didehydro-6-Methylergoline-8-One 51867-18-6
(+/-)-9,10-Didehydro-6-Methylergoline-8-One 60384-36-3
Paspalic Acid 5516-88-1
4-[n-Methyl-N-Acetonyl-(2',2'-Ethylenedioxy)]Amino-3,4-Dihydro-1H-Benzo[c,D]Indol-5-One 764710-85-2
4-[methyl(2-Oxopropyl)Amino]-3,4-Dihydro-1H-Benzo[cd]Indol-5-One 764710-84-1
N-Pivaloyl-4-[n-Methyl-N-Acetonyl-(2',2'-Ethylenedioxy)]Amino-3,4-Dihydro-1H-Benzo[c,D]Indol-5-One 764710-81-8

合成工艺路线路线简述

📜麦角酸置于水体系中,化学反应生成 D-异麦角酸
参考文献:311.麦角的生物碱.第七部分 Iso Ergine和异麦角酸
标题:311.麦角的生物碱.第七部分 Iso Ergine和异麦角酸
摘要:
DOI:10.1039/jr9360001440

海关参考信息

2901210000-乙烯
2901220000-丙烯
2902500000-苯乙烯
2902600000-乙苯
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-3968112-A
优先权日:1974-08-02
标题:Synthesis of penniclavine and elymoclavine
发明人：KORNFELD EDMUND C; BACH NICHOLAS J
权利人:LILLY CO ELI
摘要:Synthesis of penniclavine and of elymoclavine, intermediates useful therein, and novel compounds producible therefrom.

专利号:US-3923812-A
优先权日:1974-08-02
标题:Synthesis of elymoclavine
发明人：BACH NICHOLAS J; KORNFELD EDMUND C
权利人:LILLY CO ELI
摘要:Elymoclavine is prepared by oxidation of D-6-methyl-8hydroxymethyl-10 Alpha -methoxy-8-ergolene to the corresponding D-8-aldehyde followed by reduction with an active metal in acid medium.

专利号:US-2023286975-A1
优先权日:2020-07-07
标题:Improved method for the production of lysergic acid diethylamide (lsd) and novel derivatives thereof
发明人：GRILL MATTHIAS
权利人:COMPASS PATHFINDER LTD
摘要:The present invention provides an improved method for the production of lysergic acid diethylamide (LSD) for GMP purposes. Furthermore, the present invention provides novel LSD derivatives of formula I as well as their synthesis and purification. Due to the affinity of the presented substances for the 5-HT 2A receptor, the invention may find application in numerous forms of therapy, such as against depression or drug addiction.

专利号:US-4082753-A
优先权日:1976-02-17
标题:Penniclavine acetonide
发明人：KORNFELD EDMUND C; BACH NICHOLAS J
权利人:LILLY CO ELI
摘要:Synthesis of penniclavine and of elymoclavine, intermediates useful therein, and novel compounds producible therefrom.

专利号:US-4054567-A
优先权日:1975-08-11
标题:6-Methyl-8Î²-hydroxymethyl-8-Î³-substituted-9-ergolene compounds
发明人：KORNFELD EDMUND C; BACH NICHOLAS J
权利人:LILLY CO ELI
摘要:Synthesis of penniclavine and of elymoclavine, intermediates useful therein, and novel compounds producible therefrom.

专利号:CA-1051879-A
优先权日:1974-08-02
标题 :Synthesis of elymoclavine and derivatives

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主要参考文献

参考标题:Enantioefficient Synthesis Of α-Ergocryptine: First Direct Synthesis Of (+)-Lysergic Acid
作者:István Moldvai,Eszter Temesvári-Major,Mária Incze,éva Szentirmay,Eszter Gács-Baitz,Csaba Szántay |发布日期:2004.9.1
摘要:New Resolution Method And Recycling The Undesired Enantiomer. Coupling The Peptide Part With Lysergic Acid Afforded 1. Having Synthetic (+)-7 In Hand, We Can Claim The Total Synthesis Of All The Alkaloids Which Were Prepared Earlier From (+)-7 That Had Been Obtained Through Degradation Of Natural Lysergic Acid.