CAS: 45234-02-4; Lysylglutamic Acid

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Dimethyl Nα,Nε-Bis(Trifluoroacetyl)-L-Lysyl-L-Glutamate置于sodium Hydroxide体系中,用 乙醇,水 作为反应溶剂,化学反应 20.0H,以80%的收率获得产物l-赖氨酸-L-谷氨酸盐
参考文献:N-Trifluoroacyl Lysine Derivatives In The Synthesis Of L-Lysyl-L-Glutamic Acid
标题:N-Trifluoroacyl Lysine Derivatives In The Synthesis Of L-Lysyl-L-Glutamic Acid
摘要:Conditions Were Developed For Simultaneous Preparation Of N-(A) Over Circle-Trifluoroacetyl-L-Lysine And N Alpha,N-(A) Over Circle-Bis(Trifluoroacetyl)-L-Lysine At Overall Conversion Of Initial Lysine Monohydrochloride Up To 82%. By Reaction Of Dimethyl L-Glutamate With N-Alpha,N-(A) Over Circle-Bis(Trifluoroacetyl)-L-Lysyl Chloride In The Presence Of Triethylamine Or With Na-Carboxyanhydride Of N-(A) Over Circle-Trifluoroacetyl-L-Lysine With Subsequent Removing Protecting Groups In The Formed Dipeptides By Treating With Water-Ethanol Solution Of Sodium Hydroxide We Obtained L-Lysyl-L-Glutamic Acid. Physicochemical Characteristics Of Samples Obtained Coincided With Characteristics Of L-Lysyl-L-Glutamic Acid Described In The Literature Thus Suggesting That No Racemization occurred Either At The Stage Of Peptide Bond Formation Or At Deprotection.
DOI:10.1134/s1070428007100028

专利信息

专利号:US-2019177392-A1
优先权日:2014-09-23
标 题 :Synthesis of glp-1 peptides
发明人：PENIAS NAVON SHARON; NAVEH SHIRLY; VASILEIOU ZOI; BARLOS KONSTANTINOS
权利人:NOVETIDE LTD
摘要:Disclosed are processes for the synthesis of GLP-1 peptides, such as liraglutide and semaglutide, and a process for purifying liraglutide.

专利号:WO-9720061-A1
优先权日:1995-11-30
标题:Synthesis of hyaluronic acid
发明人：WONG CHI-HUEY; DELUCA CLAUDIO
权利人:SCRIPPS RESEARCH INST; WONG CHI HUEY; DELUCA CLAUDIO
摘要:A preparative enzymatic synthesis of hyaluronic acid (HA) from UDP-N-acetyl-D-glucosamine (UDP-GlcNAc) and UDP-glucuronic acid (UDP-GlcA) catalyzed by hyaluronic acid synthase is coupled with regeneration of the sugar nucleotides. Polymerizing UDP-GlcA and UDP-GlcNAc to form hyaluronic acid results in the formation of released UDP. The released UDP is, in turn, employed in the regeneration of UDP-GlcA and UDP-GlcNAc. Use of the released UDP for regenerating UDP-GlcA and UDP-GlcNAc prevents a build-up of these compounds and prevents or reduces feed back inhibition of the hyaluronic acid synthase reaction that would otherwise be caused by such build-up. Accordingly, the product yield is enhanced by the recycling of these compounds.

专利号:US-11717498-B2
优先权日:2013-12-31
标题 :Methods of treatment using amphetamine controlled release, prodrug, and abuse deterrent dosage forms
发明人：POPP KARL; MECKLER HAROLD
权利人:Chemapotheca LLC; PHARMAPOTHECA A INC
摘要:The invention also relates to pharmaceutical compositions comprising highly pure amphetamine and amphetamine-class compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds, and to methods of manufacturing, delivering, and using the amphetamine compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds.

专利号:US-12208068-B2
优先权日:2013-12-31
标题:Amphetamine controlled release, prodrug, and abuse-deterrent dosage forms
发明人：POPP KARL; MECKLER HAROLD
权利人:PHARMAPOTHECA A INC
摘要:The invention also relates to processes for producing abuse deterrent pharmaceutical compositions comprising highly pure amphetamine and amphetamine-class compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds, and to methods of manufacturing, delivering, and using the amphetamine compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds.

专利号:US-2025213502-A1
优先权日:2016-02-24
标 题 :Amphetamine Controlled Release, Prodrug, and Abuse-deterrent Dosage Forms
发明人：POPP KARL; MECKLER HAROLD
权利人:PHARMAPOTHECA A INC
摘要:The invention also relates to pharmaceutical compositions comprising highly pure amphetamine and amphetamine-class compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds, and to methods of manufacturing, delivering, and using the amphetamine compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds.

专利号:WO-9805758-A1
优先权日:1996-08-02
标题 :STRUCTURE AND EXPRESSION OF THE ALPHA-CARBOXYLTRANSFERASE SUBUNIT OF HETEROMERIC-ACETYL-CoA CARBOXYLASE
发明人：OHLROGGE JOHN B; SHORROSH BASIL S
权利人:UNIV MICHIGAN STATE; OHLROGGE JOHN B; SHORROSH BASIL S
摘要:The nucleic acid sequence encoding the alpha-carboxyltransferase (alpha-CT) subunit of acetyl-CoA carboxylase and its deduced amino acid sequence are provided. Vectors comprising the nucleic acid sequence, plant cells transformed with the vectors, as well as plants transformed with the nucleic acid sequence and seeds of the transgenic plant, are also provided. By controlling the expression of the alpha-CT gene, carboxylation of acetyl-CoA can be controlled. Thus, by introducing constructs of the gene of the present invention in sense or antisense orientation, carboxylation of acetyl-CoA to produce malonyl-CoA may be increased or decreased and fatty acid synthesis and elongation in plants and seeds which depend on malonyl-CoA may be controlled. The figure shows ACCase and CT activities and protein profiles.