CAS: 4408-78-0; Phosphonoaceticacid

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CAS号867-13-0 磷酰基乙酸三乙酯 | CAS号1067-74-9 甲基磷酰基乙酸二乙酯 | CAS号2537-48-6 氰甲基磷酸二乙酯 | CAS号72946-10-2 (iPrO)2P(O)CH2CO2Me | CAS号78939-53-4 p-nitrophenyl p... | CAS号35752-46-6 (2-ethoxy-2-oxo... | CAS号53311-88-9 propan-2-yl 2-d... | CAS号2009-81-6 [3-(dimethylami... | CAS号5927-18-4 三甲基膦酰基乙酸酯 | CAS号34164-06-2 (Dichlorophosph... | CAS号35752-46-6 (2-ethoxy-2-oxo... | CAS号36957-54-7 ethyl 2-dichlor... | CAS号70962-63-9 (2-chloro-2-oxo... | CAS号62591-72-4 1-Propyl phosph... | CAS号40203-73-4 环松油烯

📜磷酰基乙酸三乙酯置于盐酸体系中,用 水 作为反应溶剂,化学反应 9.0H,以93%的收率获得产物磷酰基乙酸
参考文献:Applications Of Mesoporous Titanium Phosphonate Functionalized With Carboxylic Groups
标题:Applications Of Mesoporous Titanium Phosphonate Functionalized With Carboxylic Groups
摘要:通过简单的协同冷凝过程,使用磷酸乙酸和四氯化钛在酸性条件下合成了功能化的介孔钛磷酸酯,具有-cooh 基团.所得到的介孔材料具有高比表面积和大孔体积,这些结果通过 Xrd,Tem,Sem 和 N2 吸附分析得到了支持.磷酸酯基团的完整性进一步通过 Ftir 和 NMR 进行了表征.通过金属吸附-还原程序,成功地将钯纳米颗粒负载到材料上,显示出在铃木反应中具有高活性.此外,所获得的催化剂可以回收利用,且催化活性没有显著下降.
DOI:10.1039/c4Ra06952H

专利信息

专利号:WO-2025053792-A1
优先权日:2023-09-06
标题:Collective synthesis of phantomolin family through total synthesis of the sesquiterpene lactone molephantin
发明人：CHIBA SHUNSUKE; PATOURET REMI HENRI LOUIS; LI HOI YEUNG; LAI SOAK KUAN
权利人:UNIV NANYANG TECH
摘要:Disclosed herein are processes to generate an intermediate in the total synthesis of (+)- molephantin or a derivative thereof, and a total synthesis of (+)-molephantin or a derivative thereof. Also disclosed herein are methods of forming a compound of formula XIV and of forming a compound of formula XV, wherein compound of formula XIV and compound of formula XV are as defined in the description.

专利号:US-2024287520-A1
优先权日:2021-06-30
标题:Method for synthesis of linkage modified oligomeric compounds
发明人：RODRIGUEZ ANDREW A
权利人:IONIS PHARMACEUTICALS INC
摘要:The present disclosure provides methods of synthesizing modified oligonucletodies and oligomeric compounds (including oligomeric compounds that are antisense agents or portions thereof) comprising a modified oligonucleotide having at least one modified internucleoside linking group. In certain embodiments, the present disclosure provides stabilized formulations of certain sulfonyl azides for use in the synthesis of olignonucleotides comprising one or more sulfonyl phosphoramidate linkages. Some embodiments provide stabilized compositions of high energy reagents that may be used in the synthesis of modified oligonucleotides, allowing for safe process scale preparation thereof.

专利号:US-11542269-B2
优先权日:2018-01-03
标 题:Prins reaction and compounds useful in the synthesis of halichondrin macrolides and analogs thereof
发明人：CHOI HYEONG-WOOK; FANG FRANCIS G
权利人:EISAI R&D MAN CO LTD
摘要:The invention provides methods utilizing Prins reaction in the preparation of compounds that may be useful as intermediates in the synthesis of halichondrin macrolides and analogs thereof. The invention also provides compounds that may be useful as intermediates in the synthesis of a halichondrin macrolides and methods for preparing the same.

专利号:US-9809566-B2
优先权日:2012-09-06
标题:Organocatalytic process for asymmetric synthesis of decanolides
发明人：RAWAT VARUN; DEY SOUMEN; SHELKE ANIL MARUTI; SURYAVANSHI GURUNATH MALLAPPA; SUDALAI ARUMUGAM
权利人:COUNCIL SCIENT IND RES
摘要:The present invention discloses organocatalytic process for asymmetric synthesis of highly enantioselective decanolide compounds in high yield with >99% ee. Further, the present invention disclose cost effective, improved organocatalytic process for asymmetric synthesis of highly enantioselective decanolides compounds from non-chiral, cheap, easily available raw materials.

专利号:US-6133409-A
优先权日:1996-12-19
标 题:Process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and αβ-unsaturated carboxylic acid and aldehyde compounds
发明人：SALVINO JOSEPH M; MORTON GEORGE C; MASON HELEN J; LABAUDINIERE RICHARD F
权利人:AVENTIS PHARM PROD INC
摘要:This invention is directed to a process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and alpha , beta -unsaturated carboxylic acid and aldehyde compounds and to polymeric hydroxylamine resin compounds useful therefor.

专利号:US-7888337-B2
优先权日:2007-08-31
标 题 :Synthesis of oseltamivir containing phosphonate congeners with anti-influenza activity
发明人：WONG CHI-HUEY; FANG JIM-MIN; SHIE JIUN-JIE; CHENG YIH-SHYUN EDMOND; JAN JIA-TSRONG
权利人:ACADEMIA SINICA
摘要:Novel phosphonate compounds are described. The compounds have activity as neuraminidase inhibitors against wild-type and H274Y mutant of H1N1 and H5N1 viruses. The present disclosure also provides an enantioselective synthetic route to known neuraminidase inhibitors oseltamivir and the anti-flu drug Tamiflu®, as well as novel phosphonate compounds, via D-xylose. Another efficient and flexible synthesis of Tamiflu and the highly potent neuraminidase inhibitor Tamiphosphor was also achieved in 11 steps and >20% overall yields from the readily available fermentation product (1S-cis)-3-bromo-3,5 -cyclohexadiene-1,2-diol. Most of the reaction intermediates were obtained as crystals without tedious purification procedures. The key transformations include an initial regio- and stereoselective bromoamidation of a bromoarene cis-dihydrodiol, as well as the final palladium-catalyzed carbonylation and phosphonylation.