CAS: 43163-94-6; 2-Amino-3-Fluoro-3-Methylbutanoic Acid

上下游产品

2-Bromo-3-fluoro-3-methyl-butyric acid amino-2 fluoro-3 methyl-3 butanonitrile 3-fluoro-2-keto-3-methybutanoic acid 2-phenyl-4-isopropylidene-5(4H)oxazolone 2-((tert-butoxycarbonyl)amino)-3-fluoro-3-methylbutanoic acid (E)-(S)-4-({2-[(S)-2-(tert-Butoxycarbonyl-methyl-amino)-3-methyl-3-phenyl-butyrylamino]-3-fluoro-3-methyl-butyryl}-methyl-amino)-2,5-dimethyl-hex-2-enoic acid tert-butyl 2-fluoro-1,2-dimethylpropyl carbamate

📜2-Phenyl-4-Isopropylidene-5(4H)Oxazolone置于盐酸,Ammonium Hydroxide,Sodium Tetrahydroborate,Acidic Ion Exchange Resin (Ag 50W-X8),碳酸氢钠,Fluorine体系中,用 1,4-二氧六环,氯仿,一氟三氯甲烷 作为反应溶剂,化学反应 24.67H,反应生成 3-氟-Dl-缬氨酸
参考文献:Addition Of Molecular Fluorine To Azlactones: General Synthetic Method Of Erythro-.Beta.-Fluorinated .Alpha.-Amino Acids.
标题:Addition Of Molecular Fluorine To Azlactones: General Synthetic Method Of Erythro-.Beta.-Fluorinated .Alpha.-Amino Acids.
摘要:分子氟与由适当醛类(或酮类)和苯甲酰甘氨酸反应生成的不饱和氮内酯反应,可得到二氟化加合物.通过碱性水解从加合物中得到的 β-氟化 α-氧代烷酸经还原胺化反应反应生成红-β-氟化脂肪族 α-氨基酸.同样的反应用于 3-苯基-2-苯甲酰氨基丙烯酸甲酯时,可得到相应的芳香族氨基酸.因此,整个序列提供了一种合成红-β-氟化 α-氨基酸的通用方法.
DOI:10.1248/cpb.43.760

专利信息

专利号:US-2022243244-A1
优先权日:2019-10-10
标 题 :Compositions and methods for in vivo synthesis of unnatural polypeptides
发明人：ROMESBERG FLOYD E; FISCHER EMIL C; HASHIMOTO KOJI; FELDMAN AARON W; DIEN VIVIAN T; ZHANG YORKE
权利人:SCRIPPS RESEARCH INST
摘要:Disclosed herein are compositions, methods, and kits for a cell incorporating unnatural amino acids into an unnatural polypeptide. Also disclosed herein are compositions, methods, and kits for increasing activity and yield of the unnatural polypeptide synthesized by the cell.

专利号:US-2023037284-A9
优先权日:2018-11-30
标题:Combination therapy of peptidomimetic macrocycles
发明人：GUERLAVAIS VINCENT; ANNIS DAVID ALLEN
权利人:AILERON THERAPEUTICS INC
摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.

专利号:US-2025084410-A1
优先权日:2015-01-12
标 题:Incorporation of unnatural nucleotides and methods thereof
发明人：PTACIN JEROD; MALYSHEV DENIS A; CAFFARO CAROLINA E
权利人:SYNTHORX INC
摘要:Disclosed herein are methods, compositions and kits for the synthesis of proteins which comprises unnatural amino acids that utilize a mutant tRNA.

专利号:US-2018371021-A1
优先权日:2017-05-11
标 题 :Peptidomimetic macrocycles and uses thereof
发明人：AIVADO MANUEL; GUERLAVAIS VINCENT; OLSON KAREN
权利人:AILERON THERAPEUTICS INC
摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.

专利号:US-12234299-B2
优先权日:2018-11-22
标 题 :Peptides for inducing bacteriocin synthesis and methods to identify and/or select and/or optimize the same
发明人：MIGNOLET JOHANN; HOLS PASCAL; LEDESMA GARCÃ?A LAURA
权利人:SYNGULON S A; UNIV CATHOLIQUE LOUVAIN
摘要:Described herein is a peptide or peptidomimetic with a length of at least 6 residues comprising, consisting essentially of, or consisting of the sequence motif Xaa1-Trp-Xaa2-Xaa3-Xaa4-Xaa5 (SEQ ID NO:1), wherein: Xaa1 represents an aromatic residue (Phe, Tyr, Trp, His), Cys or Ser; Xaa2, Xaa3 and Xaa4 represent any residue; and Xaa5 represents Gly, lie or Val.

专利号:WO-2021072167-A1
优先权日:2019-10-10
标 题:Compositions and methods for in vivo synthesis of unnatural polypeptides