CAS: 42558-54-3; Methyl 4-Methyl-3-Oxopentanoate

相似化合物

42558-54-3 55107-14-7 30414-55-2

上下游产品

CAS号563-80-4 甲基异丙基甲酮 | CAS号616-38-6 碳酸二甲酯 | CAS号50652-78-3 4-甲基-2-戊酸甲酯 | CAS号67-56-1 甲醇 | CAS号2033-24-1 丙二酸环(亚)异丙酯 | CAS号79-30-1 异丁酰氯 | CAS号6832-16-2 METHYL DIAZOACETATE | CAS号78-84-2 异丁醛 | CAS号186581-53-3 重氮甲烷 | CAS号5650-76-0 4-methyl-3-oxop... | CAS号1097776-52-7 methyl 5-propan... | CAS号1072913-35-9 methyl 2-isopro... | CAS号23251-28-7 7-羟基-4-异丙基-色烯-2-酮 | CAS号28456-53-3 4(1H)-Pyrimidin... | CAS号29211-67-4 3-异丙基-2-吡唑啉-5-酮 | CAS号278597-28-7 3-(2,6-二氯苯基)-5-... | CAS号265989-30-8 N-4-苄氧基苯基异丁酰基乙酰胺 | CAS号73576-32-6 2-氨基-4-羟基-6-异丙基嘧啶 | CAS号124401-38-3 4-甲基-3-酮基-N-苯基戊酰胺 | CAS号125971-96-2 4-氟-α-[2-甲基-1-氧...

Methyl 4-Methyl-2-Pentenoate置于sodium Tetrachloropalladate(II) 叔丁基过氧化氢体系中,用 溶剂黄146,叔丁醇 作为反应溶剂,化学反应 3.0H,以64%的收率获得产物异丁酰醋酸甲酯
参考文献:使用过氧化物作为 Pd0 的再氧化剂,通过 Pdcl2 催化 α,β-不饱和羰基化合物的区域选择性氧化制备 1,3-二羰基化合物的新方法
标题:使用过氧化物作为 Pd0 的再氧化剂,通过 Pdcl2 催化 α,β-不饱和羰基化合物的区域选择性氧化制备 1,3-二羰基化合物的新方法
摘要:使用 Na2Pdcl4 作为催化剂和叔丁基过氧化氢或过氧化氢作为 Pd0 的再氧化剂,α,β-不饱和酯和酮在乙酸水溶液中被区域选择性氧化,以非常好的收率获得产物 β-酮酯和 1,3-二酮.
DOI:10.1246/cl.1980.257

专利信息

专利号:US-9085538-B2
优先权日:2010-07-26
标题:Process for the preparation of key intermediates for the synthesis of statins or pharmaceutically acceptable salts thereof
发明人：CASAR ZDENKO; STERK DAMJAN; JUKIC MARKO
权利人:CASAR ZDENKO; STERK DAMJAN; JUKIC MARKO; LEK PHARMACEUTICALS
摘要:The invention relates to commercially viable process for the synthesis of key intermediates for the preparation of statins, in particular Rosuvastatin and Pitavastatin or respective pharmaceutically acceptable salts thereof. A new simple and short synthetic route for key intermediates is presented which benefits from the use of cheap and readily available starting materials, by which the conventionally most frequently used DIBAL-H as reducing agent can be avoided.

专利号:US-5998633-A
优先权日:1996-07-29
标 题:Process for the synthesis of protected esters of (S)-3,4-dihydroxybutyric acid
发明人：JACKS THOMAS E; BUTLER DONALD E
权利人:WARNER LAMBERT CO
摘要:The invention is an improved process for the preparation of a compound of formula I wherein R and R 1 are each independently alkyl of from 1 to 3 carbon atoms; and R 2 is alkyl of from 1 to 8 carbon atoms. ##STR1##

专利号:US-7737287-B2
优先权日:2002-03-28
标 题 :Anomeric derivatives of monosaccharides
发明人：MEUTERMANS WIM; WEST MICHAEL LEO; GIANG THANH LE; ADAMSON GEORGE; SCHAFER KARL; ABBENANTE GIOVANNI
权利人:ALCHEMIA LTD
摘要:This invention relates to combinatorial libraries of potentially biologically active mainly monosaccharide compounds and to methods of preparing same. These compounds are variously functionalized, with a view to varying lipid solubility, size, function and other properties, with the particular aim of discovering a drug or drug-like compound, or compounds with useful properties. The invention provides intermediates, processes and synthetic strategies for the solution or solid phase synthesis of monosaccharides, variously functionalized about the sugar ring, including the addition of aromaticity and charge, and the placement of amino acid and peptide side chain units of isosteres thereof.

专利号:US-5194671-A
优先权日:1991-05-23
标题 :Process for the preparation of β-ketocarboxylic acid esters
发明人：MEIER JOSEF
权利人:WACKER CHEMIE GMBH
摘要:The invention relates to a process for the preparation of β-ketocarboxylic acid esters of the general formula ##STR1## in which R 1 is an alkyl radical having 1 to 4 C atoms, R 2 is an alkyl radical or alkenyl radical having 2 to 15 C atoms or a phenyl radical and R 3 is hydrogen or an alkyl or alkenyl radical having 1 to 6 C atoms, characterized in that acetocarboxylic acid esters of the general formula ##STR2## in which R 1 and R 3 are as defined, are reacted with calcium hydroxide or calcium oxide in the presence of an organic solvent and in the absence of water, the calcium chelate complexes formed are acylated with carboxylic acid chloride and the products are then cleaved with aqueous ammonium salt solution to form the β-ketocarboxylic acid esters of formula (I). n The β-ketocarboxylic acid esters readily accessible by the process according to the invention can be used as important intermediates in the synthesis of pharmaceutically active ingredients or plant protection agents.

专利号:US-5155251-A
优先权日:1991-10-11
标题:Process for the synthesis of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate
发明人：BUTLER DONALD E; LE TUNG V; MILLAR ALAN; NANNINGA THOMAS N
权利人:WARNER LAMBERT CO
摘要:An improved process for the preparation of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate is described where a halo hydroxyester or other activated dihydroxyester is converted in two steps to the desired product.

专利号:US-5248793-A
优先权日:1990-10-17
标 题:Process for the synthesis of (4R-cis)-1,1-dimethylethyl 6-iodomethyl or 6-(phenyl-substituted)sulfonyloxymethyl-2,2-dimethyl-1,3-dioxane-4-acetate
发明人：MILLAR ALAN; BUTLER DONALD E
权利人:WARNER LAMBERT CO
摘要:An improved process for the preparation of (4R-cis)-1,1-dimethylethyl 6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate is described where a hydroxy ester derivative is converted in two steps to the desired product, as well as valuable intermediates used in the process.