专利号:US-4980291-A 优先权日:1988-02-10 标 题 :Process for the enzymatic separation of the optical isomers of racemic α-alkyl-substituted primary alcohols 发明人:BIANCHI DANIELE; CESTI PIETRO; FRANCALANCI FRANCO; CABRI WALTER 权利人:DONEGANI GUIDO IST 摘要:Biotechnological resolution by means of enzymatic transesterification of the relevant racemic mixture of the optical isomers of α-alkyl-substituted primary alcohols having the formula (I): ##STR1## wherein: R represents a linear or branched (C 1 -C 20 )-alkyl or alkenyl group or an aryl group, also substituted or condensed with other groups, in particular a group of formula (II) or (III): ##STR2## wherein: R ii represents a (C 1 -C 8 )-alkyl group, a (C 1 -C 4 )-alkenyl group, an alkoxy, phenyl, phenoxy, benzoyl, or heterocyclic group; n R iii represents a hydrogen or halogen atom; n R iv represents a (C 1 -C 4 )-alkyl group, n and wherein n R i represents a (C 1 -C 4 )-alkyl group either equal to, or different from, R, n in the presence of an enzyme either free or immobilized on a support capable of selectively causing the S isomer to be esterified, with the R isomer being left substantially unchanged, said isomers being then separated according to techniques known from the prior art. The process is used in the synthesis of antiinflammatory agents.
专利号:US-4954325-A 优先权日:1986-07-29 标题:Composition of synthetic porous crystalline material, its synthesis and use 发明人:RUBIN MAE K; CHU POCHEN 权利人:MOBIL OIL CORP 摘要:This invention relates to a new synthetic porous crystalline material, a method for its preparation and use thereof in catalytic conversion of organic compounds. The new crystalline material exhibits a distinctive X-ray diffraction pattern and unusually large equilibrium adsorption capacities.
专利号:US-5173281-A 优先权日:1991-10-07 标题 :Synthesis of a synthetic porous crystalline material 发明人:CHANG CLARENCE D; MITKO DONNA M 权利人:MOBIL OIL CORP 摘要:There is provided a method for preparing a synthetic crystalline material from a reaction mixture including an organic directing agent selected from 1,4-diazacycloheptane (i.e. homopiperazine), azacyclooctane (i.e. heptamethyleneimine), aminocyclohexane (i.e. cyclohexylamine), aminocyclopentane (i.e. cyclopentylamine) and aminocycloheptane (i.e. cycloheptylamine). The crystalline material may be an aluminosilicate zeolite having considerable catalytic activity, e.g. for hydrocarbon conversion reactions.
[参考文献]: Timothy Lynagh, Et Al. Molecular Basis For Allosteric Inhibition Of Acid-Sensing Ion Channel 1A By Ibuprofen. J Med Chem. 2017 Oct 12;60(19):8192-8200.
合成参考文献
摘要:Lamm, A. S.; Venkitasubramanian, P.; Rosazza, J. P. N., Science of Synthesis: Biocatalysis in Organic Synthesis, (2015) 2, 469.