CAS: 35694-08-7; 2,2',3,3',4,4',5,5'-Octachloro-1,1'-Biphenyl

该化合物是属于多氯联苯(PCB)家族的完全氯化的双联苯化合物,其特点是化学稳定性高,易燃性低,耐热降解的抗药性低,其八氯化结构导致其在水中的挥发性和溶解性低,使其成为环境和毒理学研究的课题.由于其反复性,它成为多氯联苯检测和量化的分析化学的参照标准.然而,其生物累积潜力和毒性需要严格的处理程序.研究应用包括研究多氯联苯代谢,环境持久性和补救技术.

英文名称2,2',3,3',4,4',5,5'-Octachloro-1,1'-Biphenyl
中文名称2,2',3,3',4,4',5,5'-八氯-1,1'-联苯
IUPAC名称1,2,3,4-tetrachloro-5-(2,3,4,5-tetrachlorophenyl)benzene
其它别名2,2',3,3',4,4',5,5'-八氯联苯; 2,2',3,3',4,4',5,5'-Octachlorobiphenyl
CAS编号35694-08-7
MFCD编号:MFCD00152681
EINECS号:621-527-8
FDA UNII编号:9UJN9A379B
分子式:C12H2Cl8分子量:429.77
产品CID: 1365488
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: DTMRKGRREZAYAP-UHFFFAOYSA-N
InChI=1S/C12H2Cl8/c13-5-1-3(7(15)11(19)9(5)17)4-2-6(14)10(18)12(20)8(4)16/h1-2H
计算化学: 氢键受体数*氢键供体数*可旋转键数1.0

MSDS等安全信息

GHS象形图
GHS符号GHS08 & GHS09;
注释: Health hazard & Environment
危险类别特定目标器官毒性-重复接触类别2
水生急性毒性类别1
水生慢性毒性类别1
警示词Warning(警告)
危险描述H373 |长期或反复接触可能损害器官.
H400 |对水生生物毒性极大.
H410 |对水生生物毒性极大并具有长期持续影响.
防范说明P260-P273-P391-P501
危险等级9
UN编号2315.0
包装等级Ⅱ
安全声明The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. Most of the toxic effects of PCBs are believed to be results of Ah receptor binding. Other PBCs are believed to interfere with calcium channels and/or change brain dopamine levels. PCBs can also cause endocrine disurption by altering the production of thyroid hormones and binding to estrogen receptors, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. They will bioaccumulate by binding to receptor proteins such as uteroglobin. (A3, A4, A30, A66)

欧盟法规

ECHA物质C&L通报

上下游产品

perchloro(2,2'-biphenylene)diphenylsilane

合成工艺路线路线简述

📜Magnesium,1,2,3,4,5-Pentachlorobenzene-6-Ide,Chloride置于sodium Hydroxide,四氯化硅体系中,用四氢呋喃用作溶剂,化学反应 26.0H,反应生成2,2',3,3',4,4',5,5'-八氯联苯
参考文献:An Unusual Cyclization Reaction In The Chemistry Of Perchloroorganic Compounds Of Silicon And Germanium. Synthesis And Crystal Structure Of Perchloro(2,2'-Biphenylene)Diphenyl-Silane And-Germane
标题:An Unusual Cyclization Reaction In The Chemistry Of Perchloroorganic Compounds Of Silicon And Germanium. Synthesis And Crystal Structure Of Perchloro(2,2'-Biphenylene)Diphenyl-Silane And-Germane
摘要:
Doi:10.1016/0022-328X(90)80062-5