CAS: 212779-21-0; 2-Amino-3-Bromo-6-Chloropyrazine

相似化合物

566205-01-4 76537-18-3 173253-42-4

上下游产品

2-氨基-5-溴-6-氯吡嗪 5-Bromo-6-Chloropyrazin-2-Amine 173253-42-4
2-氨基-6-氯吡嗪 2-Amino-6-Chloropyrazine 33332-28-4

2-氨基-6-氯吡嗪 以43的收率获得2-氨基-3-溴-6-氯吡嗪
参考文献:Pyrazine Compounds
标题:Pyrazine Compounds
摘要:化合物的公式(i),其中r1是苯基,其被一个或多个卤素原子取代,萘基和其被一个或多个卤素原子取代;R2是-nh2和-nhc(═o)Ra;R3是-nrbrc,-nhc(═o)Ra或氢;R4是氢,-c1-4烷基,-cn,-ch2Oh,-ch2Ord,-ch2S(O)Xrd和-c1-4烷基,其被一个或多个卤素原子取代,其中ra代表c1-4烷基或c3-7环烷基,而rb和rc可能相同或不同,是氢或c1-4烷基,或者与它们所连接的氮原子一起形成一个含氮的6元杂环,该杂环可以进一步被一个或多个c1-4烷基取代;Rd是c1-4烷基或c1-4烷基,其被一个或多个卤素原子取代;X是整数零,一或二;以及它们的盐,溶剂化合物和前药,但前提是当r2是-nh2时,R1不代表任何物质,而当r3和r4均为氢时,该化合物有用作镇痛剂,抗癫痫药,治疗双相障碍和神经保护剂.

专利信息

专利号:US-11590142-B2
优先权日:2018-03-28
标题 :Oxazolidinone antibiotic compounds and process of preparation
发明人：PEER MOHAMED SHAHUL HAMEED; BHARATHAM NAGAKUMAR; KATAGIHALLIMATH NAINESH; SHARMA SREEVALLI; NANDISHAIAH RADHA; RAMACHANDRAN VASANTHI
权利人:BUGWORKS RES INC
摘要:Compounds of Formula I, its stereoisomers, pharmaceutically acceptable salts, complexes, hydrates, solvates, tautomers, polymorphs, racemic mixtures, optically active forms and pharmaceutically active derivative thereof and pharmaceutical compositions containing them as the active ingredient which can be used as medicaments are provided. The aforementioned substances can also be used in the manufacture of medicaments for treatment, prevention, or suppression of diseases, and conditions mediated by microbes. Methods for the synthesis and characterization of the aforementioned substances are also provided.

专利号:US-2024239799-A1
优先权日:2021-04-02
标 题:(s)-1-(5-((pyridin-3-yl)thio)pyrazin-2-yl)-4'h,6'h-spiro[piperidine-4,5'-pyrrolo [1,2-b]pyrazol]-4'-amine derivatives and similar compounds as shp2 inhibitors for the treatment of e.g. cancer
发明人：DI FABIO ROMANO; MONTALBETTI CHRISTIAN; PETROCCHI ALESSIA; GRILLO ALESSANDRO; RANDAZZO PIETRO; ROSSETTI ILARIA; CIAMMAICHELLA ALINA
权利人:C N C C S S C A R L COLLEZIONE NAZ DEI COMPOSTI CHIMICI E CENTRO SCREENING; IRBM S P A
摘要:The present invention relates to compounds of formula (I). The compounds of the formula (I) are e.g. (S)-1-(5-((pyridin-3-yl)thio) pyrazin-2-yl)-41H,6′H-spiro[piperidine-4,5′-pyrrolo[1,2-b]pyrazol]-41-amine derivatives and similar compounds. The present invention also relates to the compounds of formula (I) for use as Src homology phosphotyrosine phosphatase 2 (SHP2) inhibitors in methods of treatment of e.g. cancer, cardiovascular diseases, immunological disorders, autoimmune disorders, fibrosis, ocular disorders, systemic lupus erythematosus, diabetes, neutropenia, and combinations thereof. The present invention also relates to pharmaceutical compositions containing said compounds and to their methods of synthesis.

专利号:US-11401277-B2
优先权日:2017-11-29
标 题 :Anti-bacterial heterocyclic compounds and their synthesis
发明人：PEER MOHAMED SHAHUL HAMEED; BHARATHAM NAGAKUMAR; KATAGIHALLIMATH NAINESH; SHARMA SREEVALLI; NANDISHAIAH RADHA; RAMACHANDRAN VASANTHI
权利人:BUGWORKS RES INC
摘要:The invention relates to compounds of Formula I and Formula (B) along with their stereoisomers, pharmaceutically acceptable salts, complexes, hydrates, solvates, tautomers, polymorphs, racemic mixtures, optically active forms, and pharmaceutically active derivatives thereof. These compounds are useful for killing or inhibiting the growth of a microorganism selected from the group consisting of bacteria, virus, fungi, and protozoa.

专利号:US-10912780-B2
优先权日:2017-06-08
标题:Heterocyclic compounds useful as anti-bacterial agents and method for production thereof
发明人：PEER MOHAMED SHAHUL HAMEED; BHARATHAM NAGAKUMAR; KATAGIHALLIMATH NAINESH; SHARMA SREEVALLI; NANDISHAIAH RADHA; RAMACHANDRAN VASANTHI; VENKATARAMAN BALASUBRAMANIAN
权利人:BUGWORKS RES INC
摘要:The present disclosure relates to compounds of Formula I, or their stereoisomers, pharmaceutically acceptable salts, complexes, hydrates, solvates, tautomers, polymorphs, racemic mixtures, optically active forms and pharmaceutically active derivatives thereof, and pharmaceutical compositions containing them as the active ingredient which can be used as medicaments. The aforementioned substances can also be used in the manufacture of medicaments for treatment, prevention or suppression of diseases, and conditions mediated by microbes. The present disclosure also relates to the synthesis and characterization of aforementioned substances.

专利号:US-7772246-B2
优先权日:2007-08-01
标题:Pyrazole compounds as RAF inhibitors
发明人：CUI JINGRONG JEAN; DEAL JUDITH GAIL; GU DANLIN; GUO CHUANGXING; JOHNSON MARY CATHERINE; KANIA ROBERT STEVEN; KEPHART SUSAN ELIZABETH; LINTON MARIA ANGELICA; MCALPINE INDRAWAN JAMES; PAIRISH MASON ALAN; PALMER CYNTHIA LOUISE
权利人:PFIZER
摘要:The present invention is directed to compounds of Formula (I), n nand to pharmaceutically acceptable salts thereof, their synthesis, and their use as Raf inhibitors.

专利号:US-10988466-B2
优先权日:2017-03-23
标题:Heterocyclic derivatives useful as SHP2 inhibitors
发明人：MA CUNBO; GAO PANLIANG; HU SHAOJING; XU ZILONG; HAN HUIFENG; WU XINPING; KANG DI
权利人:JACOBIO PHARMACEUTICALS CO LTD
摘要:This invention relates to certain novel pyrazine derivatives (Formula I) as SHP2 inhibitors which is shown as formula I, their synthesis and their use for treating a SHP2 mediated disorder. More particularly, this invention is directed to fused heterocyclic group derivatives useful as inhibitors of SHP2, methods for producing such compounds and methods for treating a SHP2-mediated disorder.