CAS: 181289-11-2; Methyl 3-Isobutyl-Glutarate

上下游产品

3-异丁基戊二酸酐 3-Isobutylglutaric Anhydride 185815-59-2

📜甲醇,3-异丁基戊二酸酐 反应 18.0H,以97%的收率获得普瑞巴林杂质17
参考文献:Ep1992609
标题:Ep1992609

专利信息

专利号:US-8476441-B2
优先权日:2009-01-29
标 题 :Intermediates in the enantioselective synthesis of 3-(aminomethyl)-5-methyl-hexanoic acid
发明人：CONNON STEPHEN JOSEPH; PESCHIULLI ALDO; MARKEY LYN
权利人:CONNON STEPHEN JOSEPH; PESCHIULLI ALDO; MARKEY LYN; TRINITY COLLEGE DUBLIN
摘要:(S)-(+)-3-(aminomethyl)-5-methyl-hexanoic acid or (S)-pregabalin is an anticonvulsive drug. In addition to its use as an anticonvulsive agent, pregabalin has also been indicated as a medicament in the treatment of anxiety, neuropathic pain and pain in patients with fibromyalgia. Provided herein are thioester intermediates in the synthesis of and processes for the synthesis of 3-(aminomethyl)-5-methyl-hexanoic acid in the (R) or (S) configuration.

专利号:US-7462738-B2
优先权日:2006-05-24
标题:Processes for the preparation of R-(+)-3-(carbamoyl methyl)-5-methylhexanoic acid and salts thereof
发明人：HEDVATI LILACH; GILBOA EYAL; AVHAR-MAYDAN SHARON
权利人:TEVA PHARMA
摘要:Provided are processes for the synthesis of R-(+)-3-(carbamoylmethyl)-5-methylhexanoic acid and salts thereof, intermediates in the synthesis of S-pregabalin.

专利号:US-2012046468-A1
优先权日:2009-01-29
标题 :Intermediates in the enantioselective synthesis of 3-(aminomethyl)-5-methyl-hexanoic acid

专利号:EP-2213659-A1
优先权日:2009-01-29
标题 :Intermediates in the Enantioselective Synthesis of 3-(Aminomethyl)-5-Methyl-Hexanoic Acid

专利号:EP-2391600-B1
优先权日:2009-01-29
标题:Intermediates in the enantioselective synthesis of 3-(aminomethyl)-5-methyl-hexanoic acid

专利号:EP-2297090-A1
优先权日:2008-06-23
标题 :Stereoselective enzymatic synthesis of (s) or (r)-iso-butyl-glutaric ester