CAS: 180-84-7; 1,7-Dioxaspiro[5.5]Undecane

上下游产品

4-[2-(4-hydroxybutyl)[1,3]dioxolan-2-yl]butan-1-ol tetrahydrofuran 3,4,5,6-tetrahydro-2H-pyran-2-one 4-(phenylthio)butan-1-ol

📜2-甲氧基四氢吡喃置于calcium Chloride体系中,用 二氯甲烷 用作溶剂,化学反应 4.0H,反应生成1,7-二氧螺环-[5,5]十一烷
参考文献:2-苯磺酰基四氢吡喃阴离子的烷基化反应及其在螺旋合成中的应用
标题:2-苯磺酰基四氢吡喃阴离子的烷基化反应及其在螺旋合成中的应用
摘要:3,4-二氢-2H-吡喃或2-甲氧基四氢吡喃与苯磺酸反应生成2-苯磺酰基四氢吡喃(1).(1)通过与羰基化合物或卤化物进行烷基化反应进行脱质子化,通过自发消除生成环状烯醇醚加成产物苯磺酸.通过萘二甲磺酸钠的还原性去磺酰化作用,将起始的加成产物与醛类截获,以得到中等收率的烷基化四氢吡喃衍生物.几个囊性烯醇醚加成产物进一步转化成spiroketals包括来自天然产物的信息素的合成和.
Doi:10.1016/s0040-4020(01)87660-2

专利信息

专利号:US-7829124-B2
优先权日:2001-04-26
标题:Use of Phyllanthus constituents for treating or preventing infections caused by hepatitis B-viruses
发明人：OTT MICHAEL; MANNS MICHAEL P
权利人:OTT MICHAEL; MANNS MICHAEL P
摘要:The disclosure relates to a method of inhibiting synthesis of viral DNA in a mammal infected with a hepatitis B virus. This method includes administering at least one Phyllanthus component or substance to a mammal infected with the hepatitis B virus. It also includes inhibiting hepatitis B viral DNA synthesis in the mammal using the Phyllanthus component or substance. The disclosure also relates to a method of inhibiting viral gene expression in a mammal infected with a hepatitis B virus. This method includes administering at least one Phyllanthus component or substance to a mammal infected with the hepatitis B virus. It also includes inhibiting expression of at least one hepatitis B viral gene in the mammal using the Phyllanthus component or substance. These methods may form part of a method of preventing or treating hepatitis B infection.

专利号:US-4814347-A
优先权日:1985-07-22
标 题:Anthelmintic spiroketals and method of use
发明人：NELSON STEPHEN J
权利人:UPJOHN CO
摘要:This invention pertains to a new method for killing and controlling worms (Helminths), new formulations for killing and controlling worms in animals, new chemical compounds, and a new synthesis of northern hemisphere intermediates for the synthesis of milbemycin and avermectin macrolides.

专利号:US-11566042-B2
优先权日:2014-11-18
标 题 :Phosphoramidite synthones for the synthesis of self-neutralizing oligonucleotide compounds
发明人：TABATADZE DAVID R; YANACHKOV IVAN B
权利人:ZATA PHARMACEUTICALS INC
摘要:Compositions and compounds of nucleoside phosphoramidites and modified oligonucleotides, each comprising one or more charge-neutralizing moieties according to the formula VThe nucleoside phosphoramidites permit facile attachment of the neutralizing moieties on the backbones of the modified oligonucleotides. The modified oligonucleotides can be used as therapeutic agents (i.e., oligotherapeutics) for the treatment of cancer, autoimmune disorders, genetic diseases, infectious diseases, neurological diseases, inflammatory diseases, metabolic diseases and others.

专利号:WO-2004058727-A1
优先权日:2002-12-20
标题 :Substituted 3,5-dihydro-4h-imidazol-4-ones for the treatment of obesity
发明人：CHEN YUANWEI; O'CONNOR STEPHEN JAMES; GUNN DAVID; NEWCOM JASON; CHEN JIANQING; YI LIN; ZHANG HAI-JUN; HUNYADI LASZLO MATYAS; NATERO REINA
权利人:BAYER PHARMACEUTICALS CORP; CHEN YUANWEI; O'CONNOR STEPHEN JAMES; GUNN DAVID; NEWCOM JASON; CHEN JIANQING; YI LIN; ZHANG HAI-JUN; HUNYADI LASZLO MATYAS; NATERO REINA
摘要:This invention relates to substituted 3,5-dihydro-4H-imidazol-4-ones compounds which are useful in the treatment of obesity and obesity-related disorders, and as weight-loss and weight-control agents. The invention also provides methods for synthesis of the compounds, pharmaceutical compositions comprising the compounds, and methods of using such compositions for inducing weight loss and treating obesity and obesity-related disorders.

专利号:US-4686297-A
优先权日:1985-07-22
标 题 :Anthelmintic spiroketals useful for killing parasitic worms
发明人：NELSON STEPHEN J
权利人:UPJOHN CO
摘要:This invention pertains to a new method for killing and controlling worms (Helminths), new formulations for killing and controlling worms in animals, new chemical compounds, and a new synthesis of northern hemisphere intermediates for the synthesis of milbemycin and avermectin macrolides.

专利号:US-4680419-A
优先权日:1985-07-22
标题:Spiroketals and process for preparing same
发明人：NELSON STEPHEN J
权利人:UPJOHN CO
摘要:This invention pertains to a new method for killing and controlling worms (Helminths), new formulations for killing and controlling worms in animals, new chemical compounds, and a new synthesis of northern hemisphere intermediates for the synthesis of milbemycin and avermectin macrolides.