CAS: 15022-15-8; 2-(Thiophen-2-yl)Acetaldehyde

该化合物是一种七环藻,具有硫苯环,与一个乙酰胆碱酯功能组相连.该化合物是有机合成的多用途中间体,特别是在制备药品,农用化学品和功能材料方面.其反应性甲酰胺组通过凝聚,减少或核循环添加反应,可以使外形衍生,而硫苯混合物会有助于目标分子的电子和结构多样性.该化合物的稳定性和与一系列反应条件的兼容性使它成为进行环球循环和精细化学应用的宝贵建筑块.建议通过对氧化和聚合的敏感度,在惰性条件下进行适当的处理.

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上下游产品

N,N'-(2-[2]thienyl-ethylidene)-bis-carbamic acid diethyl esterN,N'-(2-[2]thienyl-ethylidene)-bis-carbamic acid diethyl ester thiophene-2-carbaldehyde 2-thiophen-2-yl-oxirane 2-thiophenethanol [2]thienyl-acetaldehyde-(2,4-dinitro-phenylhydrazone) 4-phenyl-1-(thiophen-2-yl)but-3-yn-2-ol ethyl 3-benzyl-5-methyl-2-thiophen-2-ylmethyl-3H-imidazole-4-carboxylate 2-phenyl-3,5-di(thiophen-3-yl)pyridine

合成工艺路线路线简述

    📜Diethyl (2-Thienylmethyl)Malonate置于乙醇,硫酸,一水合肼,Sodium Nitrite体系中,化学反应生成噻吩-2-乙醛
    参考文献:Studies On The Chemistry Of Heterocyclics. Xix. The Application Of The Hofmann And Curtius Rearrangements To The Preparation Of 2-Thienylacetaldehydes
    标题:Studies On The Chemistry Of Heterocyclics. Xix. The Application Of The Hofmann And Curtius Rearrangements To The Preparation Of 2-Thienylacetaldehydes
    摘要:
    Doi:10.1021/jo50006A008

    海关参考信息

    专利信息


    专利号:WO-2023102600-A1
    优先权日:2021-12-06
    标题:Synthesis of amphiphilic block copolymers and polymeric nanofibers produced therefrom
    发明人:ZETTERLUND PER B; ISHIZUKA FUMI; KIM HYUN JIN; CHATANI SHUNSUKE; NIINO HIROSHI
    权利人:NEWSOUTH INNOVATIONS PTY LTD
    摘要:The present disclosure relates to the field of synthesis of block copolymers, and polymeric nanofibers having a core-shell morphology produced therefrom. The present disclosure relates to the field of synthesis of block copolymers where one block is more hydrophobic than the other block and is a different composition. The disclosure also relates to uses of these polymeric nanofibers in various applications, such as reinforcing a polymeric matrix and for coatings applications.

    专利号:US-6512081-B1
    优先权日:1997-07-21
    标题:Synthesis of dithioester chain transfer agents and use of bis(thioacyl) disulfides or dithioesters as chain transfer agents
    发明人:RIZZARDO ENZIO; THANG SAN HOA; MOAD GRAEME
    权利人:E I DUPONT NEMOURS AND COMPANY; COMMW SCIENT IND RES ORG
    摘要:This invention relates to the synthesis of dithiocarboxylic acid esters by reaction of bis(thioacyl) disulphides, thioacetals or vinylidane bis(thioether) with free-radicals (optionally in the presence of monomers). The invention also relates to processes for the synthesis of polymers utilising these dithioesters as polymerisation regulators (chain transfer agents) or to the use of bis(thioacyl) disulphides to generate dithioester chain transfer agents in situ.

    专利号:US-2014275582-A1
    优先权日:2013-03-14
    标 题 :Chiral 2-arylpropyl-2-sulfinamide and chiral n-2-arylpropyl-2-sulfinylimines and synthesis thereof
    发明人:LI GUIGEN
    权利人:LI GUIGEN; UNIV TEXAS TECH; NANJING UNIVERSITY INST OF CHEMISTRY AND BIOMEDICAL SCIENCES
    摘要:Provided herein are novel chiral sulfinamide and imine compounds. Also provided herein are methods of synthesizing novel chiral sulfinamide and imine compounds comprising simplified purification methods when compared to prior methods. The novel chiral sulfinamide and imine compounds are useful, for example, in the synthesis of complex natural products and pharmaceutical important compounds.

    专利号:WO-0125179-A1
    优先权日:1999-10-01
    标 题:Preparation of tetracyclic intermediates
    发明人:CHEN QING PING; WOODS ROSS ALEXANDER; ELLIOTT ROBYN LOUISE
    权利人:INST OF DRUG TECHNOLOGY AUSTRA; CHEN QING PING; WOODS ROSS ALEXANDER; ELLIOTT ROBYN LOUISE
    摘要:The invention provides a process for preparing deoxytetracyclic compounds of formula (I) useful in the synthesis of anthracyclines by the rearrangement of thiono ester derivatives followed by reduction, as well as intermediates useful therefor. In said formula, R is H or optionally protected OH.

    专利号:WO-2004096766-A1
    优先权日:2003-04-29
    标题 :A method of indole synthesis
    发明人:BANWELL MARTIN GERHARDT; LUPTON DAVID WILLIAM
    权利人:UNIV AUSTRALIAN; BANWELL MARTIN GERHARDT; LUPTON DAVID WILLIAM
    摘要:The present invention relates to methods for the synthesis of indoles. In particular, the invention relates to the coupling of an a-haloenone or a-haloenal with an ortho-halonitroarene to form an ortho-(enone)nitroarene or ortho-(enal)nitroarene. Reductive cyclization of an ortho-(enone)nitroarene or ortho-(enal)nitroarene affords access to indole compounds.

    专利号:US-9216953-B2
    优先权日:2012-11-02
    标题 :Chiral 2-arylpropyl-2-sulfinamide and chiral N-2-arylpropyl-2-sulfinylimines and synthesis thereof
    发明人:LI GUIGEN; PINDI SURESH
    权利人:LI GUIGEN; PINDI SURESH
    摘要:Provided herein are novel chiral sulfinamide and imine compounds. Also provided herein are methods of synthesizing novel chiral sulfinamide and imine compounds comprising simplified purification methods when compared to prior methods. The novel chiral sulfinamide and imine compounds are useful, for example, in the synthesis of complex natural products and pharmaceutical important compounds.

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    合成参考文献


    摘要:Huang, Y.; Dömling, A., Science of Synthesis: Multicomponent Reactions, (2013) 1, 538.
    摘要:Ilari, A.; Bonamore, A.; Boffi, A., Science of Synthesis: Biocatalysis in Organic Synthesis, (2015) 2, 166.
    摘要:Kwiecień, H. U., Science of Synthesis: Knowledge Updates, (2024) 3, 30.
    摘要:Tang, R.-Y., Science of Synthesis: Knowledge Updates, (2024) 1, 377.
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