CAS: 1405-90-9; Candidin
- 英文名称Candidin
- 中文名称制假丝菌素
- IUPAC名称(1S,3R,4R,9S,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-(((2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-1,3,4,9,11,17,37-heptahydroxy-15,16,18-trimethyl-7,13-dioxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
- 其它别名Amphotericin B, 8,9-Dideoxy-10-Hydroxy-7-Oxo-; Candidin; Amphotericin B, 8,9-Dideoxy-10-Hydroxy-7-Oxo-, (10R)-
- CAS编号1405-90-9
- EINECS号:215-788-3
- FDA UNII编号:1N0J75483Y
- 分子式:C47H71NO17分子量:922.08
- 产品CID: 625556
- 产品分类有机原料 → 有机氧化合物
物理性质
- 沸点800.21°C (粗估)
- 密度1.1480 (粗估)
- PH:D27 +363° (c = 0.3 in DMF); D27 +205° (c = 0.3 in glacial acetic acid)
- pKa:3.72±0.70(预测)
- PSA:316.45
- LogP:-0.4
- 折射率1.5280 (估算)
- 外观形态固体-粉末
- 储存条件Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
- 产品应用该化合物是被杀死的酵母细胞的悬浮, 通常用于延迟超敏度的皮肤试验, 以评估在试验与其他类似试验同时进行时病人的免疫细胞能力.
MSDS等安全信息
合成工艺路线路线简述
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2901241000-1,3-丁二烯
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供应商参考报价(招募中)
品牌试剂参考报价(招募中)
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主要参考文献
1: Candon S, Rammaert B, Foray AP, Moreira B, Gallego Hernanz MP, Chatenoud L, Lortholary O. Chronic Disseminated Candidiasis During Hematological Malignancies: An Immune Reconstitution Inflammatory Syndrome With Expansion of Pathogen-Specific T Helper Type 1 Cells. J Infect Dis. 2020 May 11;221(11):1907-1916. doi: 10.1093/infdis/jiz688. 44(9):1882-1888. Chinese. doi: 10.19540/j.cnki.cjcmm.20190111.005. 66(1):27-37. Spanish. doi: 10.29262/ram.v66i1.531. 54(1):182-190. doi: 10.1007/s12020-016-1061-z. Epub 2016 Aug 3. 53(6):476-8. doi: 10.1002/mrc.4211. Epub 2015 Apr 27. 6(12):1255-64. doi: 10.2217/imt.14.89. 154(1):72-83. doi: 10.1016/j.clim.2014.06.009. Epub 2014 Jun 30. 71(1):120-8. doi: 10.1136/annrheumdis-2011-200063. Epub 2011 Sep 12. 44(5):542-5. doi: 10.1590/s0037-86822011005000054. Epub 2011 Aug 26. 30(5):659-68. doi: 10.1007/s10875-010-9430-5. Epub 2010 Jun 11. 23(3):407-11. doi: 10.1002/ptr.2643. 25(1):32-6. Spanish. doi: 10.1016/s1130-1406(08)70008-1. 176(4):409-16. doi: 10.1164/rccm.200701-084OC. Epub 2007 May 31. 65(6):577-80. doi: 10.1111/j.1365-3083.2007.01941.x. 23(3):299. doi: 10.1111/j.1525-1470.2006.00240.x. 191(10):1670-9. doi: 10.1086/429670. Epub 2005 Apr 5. 158(4):407-14. doi: 10.1007/s11046-004-3126-4. 101(33):11992-5. doi: 10.1073/pnas.0401552101. Epub 2004 Jun 10.
19: Arzumanyan VG, Serdyuk OA, Kozlova NN, Basnak'yan IA, Fedoseeva VN. IgE and IgG antibodies to Malassezia spp. yeast extract in patients with atopic dermatitis. Bull Exp Biol Med. 2003 May;135(5):460-3. doi: 10.1023/a:1024967426025. 80(8):450-4. French.
合成参考文献
摘要:CRC Handbook of Antibiotic Compounds, Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980, 2(288), 1980
摘要:Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals, 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989, 11(263), 1989
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