CAS: 13656-60-5; 2,4-Difluorobenzenesulfonamide

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502642-77-5 60230-37-7 30058-40-3

上下游产品

CAS号1336-21-6 氨水 | CAS号13918-92-8 2,4-二氟笨磺酰氯 | CAS号372-18-9 1,3-二氟苯 | CAS号26120-88-7 2,4-dichloroben... | CAS号3782-65-8 2,4-Difluoroben...

1,3-二氟苯置于氯磺酸,Ammonium Hydroxide体系中,用 1,4-二氧六环 用作溶剂,化学反应 13.0H,反应生成2,4-二氟苯磺酰胺
参考文献:Synthesis And Cyclooxygenase-2 Inhibiting Property Of 1,5-Diarylpyrazoles With Substituted Benzenesulfonamide Moiety As Pharmacophore: Preparation Of Sodium Salt For Injectable Formulation†
标题:Synthesis And Cyclooxygenase-2 Inhibiting Property Of 1,5-Diarylpyrazoles With Substituted Benzenesulfonamide Moiety As Pharmacophore: Preparation Of Sodium Salt For Injectable Formulation†
摘要:A Series Of 1,5-Diarylpyrazoles Having A Substituted Benzenesulfonamide Moiety As Pharmacophore Was Synthesized And Evaluated For Cyclooxygenase (Cox-1/cox-2) Inhibitory Activities. Through Sar And Molecular Modeling,It Was Found That Fluorine Substitution On The Benzenesulfonamide Moiety Along With An Electron-Donating Group At The 4-Position Of The 5-Aryl Ring Yielded Selectivity As Well As Potency For Cox-2 Inhibition In Vitro. Among Such Compounds 3-Fluoro-4-[5-(4-Methoxyphenyl)-3-Trifluoromethyl-1H-1-Pyrazolyl]-1-Benzenesulfonamide 3 Displayed Interesting Pharmacokinetic Properties Along With Antiinflammatory Activity In Vivo. Among The Sodium Salts Tested In Vivo,10,The Propionyl Analogue Of 3,Showed Excellent Antiinflammatory Activity And Therefore Represents A New Lead Structure For The Development Of Injectable Cox-2 Specific Inhibitors.
Doi:10.1021/jm020563G

专利信息

专利号:US-6639023-B1
优先权日:1998-06-24
标题:Fluorophenyl resin compounds
发明人：SALVINO JOSEPH M; GRONEBERG ROBERT D; AIREY JOHN E; POLI GREGORY B; MCGEEHAN GERARD M; LABAUDINIERE RICHARD F; CLERC FRANCOIS-FREDERIC; BEZARD DANIEL NOEL ANDRE
权利人:AVENTIS PHARMA INC
摘要:This invention is directed to a fluorophenyl resin compound, to methods of its preparation; and to its use in the solid phase synthesis of amides, peptides, hydroxamic acids, amines, urethanes, carbonates carbamates, sulfonamides and α-substituted carbonyl compounds.

专利号:WO-2024115549-A1
优先权日:2022-11-30
标题:Aryl- and heteroaryl-sulfonamide derivatives as ccr8 modulators
发明人：AISSAOUI HAMED; CORMINBOEUF OLIVIER; DIETHELM STEFAN; REMEN LUBOS; RICHARD-BILDSTEIN SYLVIA
权利人:IDORSIA PHARMACEUTICALS LTD
摘要:The present invention relates to compounds of Formula (I), their synthesis and use as CCR8 receptor modulators in medicine.