CAS: 123654-26-2; 4-Amino-5-Chloro-2,3-Dihydrobenzofuran-7-Carboxylic Acid

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123654-26-2 182808-04-4 1378786-48-1

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CAS号143878-29-9 4-乙酰胺氨基-5-氯-7-苯... | CAS号4093-28-1 4-乙酰氨基水杨酸甲酯 | CAS号110751-41-2 methyl 4-acetam... | CAS号202664-83-3 methyl 4-acetam... | CAS号202664-85-5 4-乙酰氨基-2-羟基-3-(... | CAS号149466-67-1 4-乙酰氨基-2,3-二氢苯并...

4-乙酰氨基-5-氯-2-羟基苯甲酸甲酯置于n-溴代丁二酰亚胺(Nbs),丙二醇甲醚,水,Potassium Carbonate,Sodium Hydroxide,锌体系中,用 N,N-二甲基乙酰胺,N,N-二甲基甲酰胺 用作溶剂,化学反应 36.0H,反应生成4-氨基-5-氯-2,3-二氢苯并呋喃-7-羧酸
参考文献:一种琥珀酸普卡必利中间体4-氨基-5-氯-2,3-二氢苯并呋喃-7-羧酸的合成方法
标题:一种琥珀酸普卡必利中间体4-氨基-5-氯-2,3-二氢苯并呋喃-7-羧酸的合成方法
摘要:本发明属于医药技术领域,涉及一种普卡必利中间体4‑氨基‑5‑氯‑2,3‑二氢苯并呋喃‑7‑羧酸的合成方法.本发明以对氨基水杨酸为起始原料,经酯化,酰化,两次卤代得到4‑乙酰胺基‑3‑溴‑5‑氯‑2‑羟基苯甲酸甲酯,再与1,2‑二溴乙烷发生取代反应得到4‑乙酰胺基‑3‑溴‑2‑(2‑溴乙氧基)‑5‑氯苯甲酸甲酯,再经环合,水解得到最终产物.本发明原料易得,操作简单温和,生产周期短,纯度高,安全性好,成本低,适合工业化生产.

专利信息

专利号:CN-105294620-A
优先权日:2014-06-16
标题 :Synthesis of 4-amino-5-chloro-2,3-dihydro-7-benzofurancarboxylic acid

专利号:CN-104016949-A
优先权日:2014-06-25
标题 :Synthesis of 4-amino-5-chloro-2,3-dihydrobenzofuran-7-carboxylic acid

专利号:RU-2070884-C1
优先权日:1990-03-06
标题:Derivatives of n-(4-piperidinyl)-(dihydrobenzofuran or dihydro-2h-benzopyran)-carboxamide or their salts, or their stereoisomers, methods of their synthesis, intermediate compounds for their, pharmaceutical composition based on derivatives of n-(4-piperidinyl)-(dihydrobenzofuran or dihydro-2h-benzopyran)-carboxamide

专利号:RU-2154634-C2
优先权日:1994-09-27
标题 :Derivatives of phenyloxoalkyl-(4-piperidinyl)-benzoate, methods of their synthesis, pharmaceutical composition based on thereof and method of its preparing and intermediate compound

专利号:CN-111620857-A
优先权日:2020-06-04
标 题:A kind of continuous synthesis method of prucalopride succinate