CAS: 912347-94-5; 1-(2-Amino-4-Methoxy-3-Methylphenyl)Ethanone

该化合物是一种有机化合物,具有甲氧基组,氨基氨基甲基安眠酮组和附于苯环的乙酰基组,其特征是分子结构,包括一个甲基组和一个有助于其反应和潜在生物活动的氨基安乐组,乙酰组的存在表明它可能参与催化反应,而甲氧组则可以影响其溶解性和极性.通常,此类化合物可能具有诸如有机溶剂中中度至高溶解性等特性,并具有不同程度的稳定性,视环境条件而定.此外,氨基组可能具有基本特征,允许与酸和其他电极相互作用.总体而言,2-甲基-3-氨基-氨卡-甲基乙酰胺-甲酰甲基甲酰胺醚可能用于制药或作为有机合成的中间体,尽管具体应用将取决于对其生物活动和化学行为的进一步研究.

英文名称1-(2-Amino-4-Methoxy-3-Methylphenyl)Ethanone
中文名称2-甲基-3-氨基-4-乙酰基苯甲醚
IUPAC名称1-(2-amino-4-methoxy-3-methylphenyl)ethan-1-one
其它别名2-氨基-3-甲基-4-甲氧基苯乙酮; Ethanone, 1-(2-Amino-4-Methoxy-3-Methylphenyl)-
CAS编号912347-94-5
MFCD编号:MFCD11042290
EINECS号:833-546-0
分子式:C10H13NO2
分子量:179.22
产品CID: 1947174
产品分类有机原料→分子砌块→芳环类化合物→苯类化合物

相似结构搜索
InChIKey: VXBGCEDOGYNWHE-UHFFFAOYSA-N
InChI=1S/C10H13NO2/c1-6-9(13-3)5-4-8(7(2)12)10(6)11/h4-5H,11H2,1-3H3…
计算化学: 氢键受体数3.0氢键供体数1.0可旋转键数2.0

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别皮肤腐蚀/刺激类别2
严重眼刺激类别2
警示词Warning(警告)
危险描述H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
危险品标志Xi

欧盟法规

C&L通报

上下游产品

合成工艺路线路线简述

19500-02-8 = 912347-94-5
反应条件:1.1 Reagents: Boron Trichloride Solvents: Dichloromethane,P-Xylene; 30 Min,0 °C1.2 30 Min,0 °C1.3 Reagents: Aluminum Chloride Solvents: Dichloromethane; 0 °C; 45 Min,0 °C; 0 °C -> 70 °C; 18 H,70 °C; 70 °C -> Rt1.4 Reagents: Water; Rt; Rt -> 70 °C; 1 H,70 °C
标题:Discovery Of Novel Urea-Based Hepatitis C Protease Inhibitors With High Potency Against Protease-Inhibitor-Resistant Mutants
作者:Kazmierski,Wieslaw M.; Et Al
参考文献:Journal Of Medicinal Chemistry 日期:2012 卷标:55(7) 页码:3021-3026]

164082-77-3 = 912347-94-5
反应条件:1.1 Reagents: Trifluoroacetic Acid Solvents: Dichloromethane; 20 °C2.1 Catalysts: Boron Trichloride Solvents: Xylene; 0 °C2.2 Catalysts: Aluminum Chloride Solvents: Dichloromethane; 0 °C -> 70 °C
标题:Discovery Of Novel Potent And Selective Dipeptide Hepatitis C Virus Ns3/4A Serine Protease Inhibitors
作者:Raboisson,Pierre; Et Al
参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2008 卷标:18(18) 页码:5095-5100]

5460-31-1 = 912347-94-5
反应条件:1.1 Reagents: Sodium Hydride Catalysts: Tetrabutylammonium Bromide Solvents: Water; 0.5 H,Rt1.2 2 H,Rt1.3 Reagents: Sodium Hydroxide Solvents: Water; 0.5 H,Rt2.1 Reagents: Aluminum Chloride Solvents: 1,2-Dichloroethane; 0.5 H,Cooled2.2 8 H,Cooled3.1 Reagents: Iron,Ammonium Chloride Solvents: Ethanol; 0.5 H,Reflux
标题:Synthesis Of 2-(4-Isopropylthiazol-2-Yl)-7-Methoxy-8-Methylquinolin-4-Ol
作者:An,Chenhong; Et Al
参考文献:Zhongguo Yiyao Gongye Zazhi 日期:2015 卷标:46(10) 页码:1069-1072]

55289-06-0 = 912347-94-5
反应条件:1.1 Reagents: Triethylamine,Diphenylphosphoryl Azide Solvents: Toluene; 100 °C1.2 Solvents: Toluene; 100 °C2.1 Reagents: Trifluoroacetic Acid Solvents: Dichloromethane; 20 °C3.1 Reagents: Boron Trichloride Solvents: Xylene; 0 °C3.2 Reagents: Aluminum Chloride Solvents: Dichloromethane; 0 - 70 °C
标题:Structure-Activity Relationship Study On A Novel Series Of Cyclopentane-Containing Macrocyclic Inhibitors Of The Hepatitis C Virus Ns3/4A Protease Leading To The Discovery Of Tmc435350
作者:Raboisson,Pierre; Et Al
参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2008 卷标:18(17) 页码:4853-4858]

1640962-73-7 = 912347-94-5
反应条件:1.1 Reagents: Iron,Ammonium Chloride Solvents: Ethanol; 0.5 H,Reflux
标题:Synthesis Of 2-(4-Isopropylthiazol-2-Yl)-7-Methoxy-8-Methylquinolin-4-Ol
作者:An,Chenhong; Et Al
参考文献:Zhongguo Yiyao Gongye Zazhi 日期:2015 卷标:46(10) 页码:1069-1072]

19500-02-8 = 912347-94-5
反应条件:1.1 Catalysts: Boron Trichloride Solvents: Xylene; 0 °C1.2 Catalysts: Aluminum Chloride Solvents: Dichloromethane; 0 °C -> 70 °C
标题:Discovery Of Novel Potent And Selective Dipeptide Hepatitis C Virus Ns3/4A Serine Protease Inhibitors
作者:Raboisson,Pierre; Et Al
参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2008 卷标:18(18) 页码:5095-5100]

19500-02-8 = 912347-94-5
反应条件:1.1 Reagents: Boron Trichloride Solvents: Xylene; 0 °C1.2 Reagents: Aluminum Chloride Solvents: Dichloromethane; 0 - 70 °C
标题:Structure-Activity Relationship Study On A Novel Series Of Cyclopentane-Containing Macrocyclic Inhibitors Of The Hepatitis C Virus Ns3/4A Protease Leading To The Discovery Of Tmc435350
作者:Raboisson,Pierre; Et Al
参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2008 卷标:18(17) 页码:4853-4858]

164082-77-3 = 912347-94-5
反应条件:1.1 Reagents: Trifluoroacetic Acid Solvents: Dichloromethane; 20 °C2.1 Reagents: Boron Trichloride Solvents: Xylene; 0 °C2.2 Reagents: Aluminum Chloride Solvents: Dichloromethane; 0 - 70 °C
标题:Structure-Activity Relationship Study On A Novel Series Of Cyclopentane-Containing Macrocyclic Inhibitors Of The Hepatitis C Virus Ns3/4A Protease Leading To The Discovery Of Tmc435350
作者:Raboisson,Pierre; Et Al
参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2008 卷标:18(17) 页码:4853-4858]

4837-88-1 = 912347-94-5
反应条件:1.1 Reagents: Aluminum Chloride Solvents: 1,2-Dichloroethane; 0.5 H,Cooled1.2 8 H,Cooled2.1 Reagents: Iron,Ammonium Chloride Solvents: Ethanol; 0.5 H,Reflux
标题:Synthesis Of 2-(4-Isopropylthiazol-2-Yl)-7-Methoxy-8-Methylquinolin-4-Ol
作者:An,Chenhong; Et Al
参考文献:Zhongguo Yiyao Gongye Zazhi 日期:2015 卷标:46(10) 页码:1069-1072]

55289-06-0 = 912347-94-5
反应条件:1.1 Reagents: Triethylamine,Diphenylphosphoryl Azide Solvents: Toluene; 100 °C1.2 Solvents: Toluene; 100 °C2.1 Reagents: Trifluoroacetic Acid Solvents: Dichloromethane; 20 °C3.1 Catalysts: Boron Trichloride Solvents: Xylene; 0 °C3.2 Catalysts: Aluminum Chloride Solvents: Dichloromethane; 0 °C -> 70 °C
标题:Discovery Of Novel Potent And Selective Dipeptide Hepatitis C Virus Ns3/4A Serine Protease Inhibitors
作者:Raboisson,Pierre; Et Al
参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2008 卷标:18(18) 页码:5095-5100

2-甲基-3-甲氧基苯胺置于三氯化铝盐酸,三氯化硼体系中,用二氯甲烷,乙腈作为反应溶剂,以2.31 G (43%)的收率获得产物2-甲基-3-氨基-4-乙酰基苯甲醚
参考文献:Novel Macrocyclic Inhibitors Of Hepatitis C Virus Replication
标题:Novel Macrocyclic Inhibitors Of Hepatitis C Virus Replication
摘要:该实施例提供了一般式i,Ii,Iii,Iv,V,Vi,Vii和x的化合物,以及包括药物组合物在内的组合物,其中包括一种主体化合物.该实施例还提供了治疗方法,包括治疗丙型肝炎病毒感染的方法和治疗肝纤维化的方法,这些方法通常涉及向需要的个体施用一种主体化合物或组合物的有效量.