CAS: 879-48-1; Ethyl 2-Amino-2-Phenylacetate Hydrochloride
该化合物是一种在制药合成中广泛使用的手性中间体,特别是在生产β-光化抗生素和其他精密化学品方面,其盐酸盐形式增强了稳定性和溶性,便利了处理和储存.该化合物由于其对应纯度,在药物开发中成为非对称合成的关键构件,在药物开发中能够进行精确的立体化学控制.其乙酯组改进了在双硫联产和其他有机转化中的回动性.该产品具有高纯度和一贯性能,因此它是需要受控的手艺环境的研究和工业应用的可靠选择.
- 英文名称Ethyl 2-Amino-2-Phenylacetate Hydrochloride
- 中文名称2-氨基-2-苯基乙酸乙酯,盐酸
- IUPAC名称ethyl 2-amino-2-phenylacetate hydrochloride
- 其它别名2-氨基-2-苯基乙酸乙酯,盐酸; Phenylglycine Ethyl Ester Hydrochloride
- CAS编号879-48-1
- MFCD编号:MFCD00114583
- EINECS号:212-907-0
- FDA UNII编号:N3FVZ6FK48
- 分子式:C10H14ClNO2分子量:215.68
- 产品CID: 1888544
- 产品分类有机原料→分子砌块→芳环类化合物→苯类化合物
物理性质
MSDS等安全信息
合成工艺路线路线简述
- 69555-14-2 + 47252-14-2 = 879-48-1
反应条件:1.1 Solvents: Dimethylformamide1.2 Reagents: Hydrochloric Acid Solvents: Diethyl Ether,Water1.3 Reagents: Hydrochloric Acid Solvents: Diethyl Ether
标题:Selective Monophenylation Of An Active Methylene Compound
作者:O'Donnell,Martin J.; Et Al
参考文献:Tetrahedron Letters 日期:1989 卷标:30(30) 页码:3909-12]
69555-14-2 + 47252-14-2 = 879-48-1
反应条件:1.1 Solvents: Dimethylformamide; Reflux
标题:Triphenylbismuth Carbonate
作者:Finet,Jean-Pierre
参考文献:E-Eros Encyclopedia Of Reagents For Organic Synthesis 日期:2001]
2935-35-5 = 879-48-1
反应条件:1.1 Reagents: Thionyl Chloride
标题:Enzymic Reactions In Aqueous-Organic Media. Xvii. Optical Resolution Of Amino Acid Esters By Enzymic Hydrolysis In Organic Solvents
作者:Tomiuchi,Yoshimasa; Et Al
参考文献:Bulletin Of The Chemical Society Of Japan 日期:1992 卷标:65(10) 页码:2599-603
📜Ethyl α-<(Diphenylmethylene)Amino>-(+/-)-Benzeneacetate置于盐酸体系中,用 乙醚,水 作为反应溶剂,化学反应 2.0H,反应生成 α-氨基-2-苯乙酸乙酯盐酸盐
参考文献:Selective Monophenylation Of An Active Methylene Compound
标题:Selective Monophenylation Of An Active Methylene Compound
摘要:
DOI:10.1016/s0040-4039(00)99281-5
海关参考信息
- 2902600000-乙苯
2909110000-乙醚
2912110000-甲醛
2912120000-乙醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-7250410-B2
优先权日:2001-06-07
标题:Cyclic nucleotide phosphodiesterase inhibitors, preparation and uses thereof
发明人：BOURGUIGNON JEAN-JACQUES; LAGOUGE YAN; LUGNIER CLAIRE; KLOTZ EVELINE; MACHER JEAN-PAUL; RABOISSON PIERRE; SCHULTZ DOMINIQUE
权利人:VIA PHARMACEUTICALS INC
摘要:The invention concerns novel benzodiazepine derivatives and their uses in the field of therapeutics particularly for treating pathologies involving the activity of a cyclic nucleotide phosphodiesterase. It also concerns methods for preparing them and novel synthesis intermediates. The inventive compounds more particularly correspond to general formula (I):
专利号:CN-118580159-A
优先权日:2024-05-21
标 题:Synthesis method of nitrogen heterocyclic aromatic hydrocarbon modified beta-amino acid ester
专利号:CN-118930443-A
优先权日:2024-06-28
标 题 :Synthesis method of trimebutine intermediate and trimebutine maleate
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
参考标题:A Convenient Synthesis Of Protected (R)-α-Phenylproline Derivatives Using The Mitsunobu Reaction作者:J. Van Betsbrugge,D. Tourwé,B. Kaptein,H. Kierkels,R. Broxterman |发布日期:1997.7
摘要:Hydrolysis, The Resulting α-Allylphenylglycine Ethyl Ester Was Enzymatically Resolved Using Ple. Hydroboration And Oxidation Of The Double Bond, Boc-Protection And Subsequent Ring Closure Using The Mitsunobu Reaction Protocol Gave Rise To Boc-(R)-α-Phenylproline Ethyl Ester.
📝 需求与反馈
尽可能描述清楚需求与问题信息
