CAS: 863888-33-9; Flurpiridaz

上下游产品

2-叔丁基-4-氯-5-[4-(2-羟基乙氧基甲基)苄氧基]-3-(2H)-哒嗪酮 2-(Tert-Butyl)-4-Chloro-5-((4-((2-Hydroxyethoxy)Methyl)Benzyl)Oxy)Pyridazin-3(2H)-One 863888-31-7
2-Tert-Butyl-5-{4-[2-(Tert-Butyldimethyl-Silanyloxy)Ethoxymethyl]Benzyloxy}-4-Chloro-2H-Pyridazin-3-One 863888-30-6
2-((4-(((1-(Tert-Butyl)-5-Chloro-6-Oxo-1,6-Dihydropyridazin-4-yl)Oxy)Methyl)Benzyl)Oxy)Ethyl 4-Methylbenzenesulfonate 863888-32-8
哒嗪酮 2-Tert-Butyl-4,5-Dichloro-2H-Pyridazin-3-One 84956-71-8

📜Toluene-4-Sulfonic Acid 2-[4-(1-Tert-Butyl-5-Chloro-6-Oxo-1,6-Dihydro-Pyridazin-4-Yloxymethyl)-Benzyloxy]-Ethyl Ester置于potassium Fluoride,4,7,13,16,21,24-六氧-1,10-二氮双环[8.8.8]二十六烷体系中,用 乙腈 作为反应溶剂,化学反应 0.17H,以79%的收率获得产物2-叔丁基-4-氯-5-[[4-(2-氟乙氧基甲基)苯基]甲氧基]哒嗪-3-酮
参考文献:Contrast Agents For Applications Including Perfusion Imaging
标题:Contrast Agents For Applications Including Perfusion Imaging
摘要:本发明在一定程度上涉及用于成像中枢神经系统或癌症的化合物和方法,包括向受试者施用包含结合mc-I的化合物和成像基团的造影剂,并利用诊断成像对受试者进行扫描.

专利信息

专利号:US-9603951-B2
优先权日:2010-02-08
标题 :Methods and apparatus for synthesizing imaging agents, and intermediates thereof
发明人：LAZEWATSKY JOEL; DEVINE MARYBETH
权利人:LANTHEUS MEDICAL IMAGING INC
摘要:The present invention generally relates to methods and system for the synthesis of imaging agents, and precursors thereof. The methods may exhibit improved yields and may allow for the large-scale synthesis of imaging agents, including imaging agents comprising a radioisotope (e.g., 18 F). Various embodiments of the invention may be useful as sensors, diagnostic tools, and the like. In some cases, methods for evaluating perfusion, including myocardial perfusion, are provided. Synthetic methods of the invention have also been incorporated into an automated synthesis unit to prepare and purify imaging agents that comprise a radioisotope. In some embodiments, the present invention provides a novel methods and systems comprising imaging agent 1, including methods of imaging in a subject comprising administering a composition comprising imaging agent 1 to a subject by injection, infusion, or any other known method, and imaging the area of the subject wherein the event of interest is located.

专利号:US-9919064-B2
优先权日:2012-08-10
标 题 :Compositions, methods, and systems for the synthesis and use of imaging agents
发明人：CESATI RICHARD R; RADEKE HEIKE S; PANDEY SURESH K; PUROHIT AJAY; ROBINSON SIMON P
权利人:LANTHEUS MEDICAL IMAGING INC
摘要:The present invention provides compounds with imaging moieties for imaging a subject. The present invention also relates to systems, compositions, and methods for the synthesis and use of imaging agents, or precursors thereof. An imaging agent precursor may be converted to an imaging agent using the methods described herein. In some cases, a composition or plurality of imaging agents is enriched in 18 F. In some cases, an imaging agent may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs.

专利号:US-12162009-B2
优先权日:2018-03-29
标题 :Solid phase purification
发明人：ENGELL TORGRIM; JACKSON ALEXANDER; KHAN IMTIAZ AHMED; CLARKE ALAN P; MCROBBIE GRAEME; GRIGG JULIAN
权利人:GE HEALTHCARE LTD
摘要:The present invention provides a method for the synthesis of an injectable composition comprising a [ 18 F]-labelled pyridaben derivative that is amenable to automation. In particular, the method of the present invention comprises a method of purification carried out by means of solid phase extraction (SPE) alone.

专利号:US-2018318456-A1
优先权日:2012-08-10
标题:Compositions, methods, and systems for the synthesis and use of imaging agents

专利号:US-2020230264-A1
优先权日:2012-08-10
标 题 :Compositions, methods, and systems for the synthesis and use of imaging agents

专利号:US-2024100199-A1
优先权日:2012-08-10
标 题:Compositions, methods, and systems for the synthesis and use of imaging agents