CAS: 86096-35-7; (R)-2-(Benzyloxycarbonylamino)-3-Methoxypropanoic Acid

该化合物是一个有独特(R)配置的手性构件,具有高对应纯度.该化合物是合成手性有机分子,特别是需要3-甲基代谢物的分子的理想化合物.其苯氧基碳基(Boc)保护组促进受控的去保护,使其成为制药和精细化学合成的多用途中间体.

英文名称(R)-2-(Benzyloxycarbonylamino)-3-Methoxypropanoic Acid
中文名称N-苄氧羰基-O-甲基-D-丝氨酸
IUPAC名称N-((benzyloxy)carbonyl)-O-methyl-D-serine
其它别名Cbz-O-Methyl-D-Serine; (R)-2-Benzyloxycarbonylamino-3-Methoxypropionic Acid; O-Methyl-N-[(Phenylmethoxy)Carbonyl]-D-Serine; (2R)-2-{[(Benzyloxy)Carbonyl]Amino}-3-Methoxypropanoic Acid; D-Serine, O-Methyl-N-[(Phenylmethoxy)Carbonyl]-
CAS编号86096-35-7
MFCD编号:MFCD08063283
分子式:C12H15NO5分子量:253.25
产品CID: 1861294
产品分类有机原料→生命科学→氨基酸及其衍生物→丝氨酸及其衍生物

相似结构搜索
InChIKey: LQHGCFKPNOTYIQ-SNVBAGLBSA-N
InChI=1S/C12H15NO5/c1-17-8-10(11(14)15)13-12(16)18-7-9-5-3-2-4-6-9/h2-6,10H,7-8H2,1H3,(H,13,16)(H,14,15)/t10-/m1/s1
计算化学: 氢键受体数4.0氢键供体数2.0可旋转键数6.0

相似化合物

64356-74-7 1145-80-8 19794-53-7

MSDS等安全信息

上下游产品

CAS号196601-68-0 拉科酰胺中间体

合成工艺路线路线简述

📜(2R)-Methyl-2-(Benzyloxycarbonylamino)-3-Methoxypropanoate置于碳酸氢钠体系中,化学反应 24.0H,反应生成 N-苄氧羰基-O-甲基-D-丝氨酸
参考文献:Synthesis And Anticonvulsant Activities Of (R)-(O)-Methylserine Derivatives
标题:Synthesis And Anticonvulsant Activities Of (R)-(O)-Methylserine Derivatives
摘要:Efficient Procedures For The Synthesis Of (R)-N-Benzyl-2-Amino-3-Methoxypropionamide ((R)-3),2-Acetamido-3-Methoxypropionic Acid (4),And O-Methylserine (5) Are Described Beginning From (R)-Cbz-Serine ((R)-7). The Reactions Proceeded With Little Or No Racemization And Permitted The Synthesis Of The Potent Anticonvulsant (R)N-Benzyl-2-Acetamido-3-Methoxypropionamide ((R)-2). The Anticonvulsant Activities Of 2-4 Were Determined Revealing The Surprising Activity Of (R)-2. (C) 1998 Elsevier Science Ltd. All Rights Reserved.
DOI:10.1016/s0957-4166(98)00403-0

海关参考信息

2902300000-甲苯
2905121000-正丙醇
2905399001-1,3-丙二醇
2906210000-苄醇
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专利信息

专利号:US-10414720-B2
优先权日:2016-09-28
标题:Process for the preparation of lacosamide
发明人：SATHE DHANANJAY G; DAS ARIJIT; Raikar Sanjay; BHAGWATKAR RAHUL; AHIRE RAMDAS
权利人:UNICHEM LAB LTD
摘要:The present invention relates to an improved process for the synthesis of (R)-Lacosamide in which free base of O-methyl-N-benzyl-D-Serinamide is not isolated before acylation. The process avoids the use of column chromatography and chiral resolution for the preparation of different stages of Lacosamide.