CAS: 858431-29-5; 3-(Chloromethyl)Pyridin-2-Amine
该化合物是多种化学中间体,主要用于制药和农用化学合成,其活性氯甲基组有助于进一步发挥作用,对构建异环化合物和活性药物成分(API)很有价值.盐盐状增强稳定性和溶性,确保合成应用的一贯性能.该化合物对于制作基于的衍生物特别有用,这些衍生物是发现和开发药物的有机组成部分.高纯度和定义明确的再活性使研究人员和工业化学家有可靠的选择.建议适当处理,因为在某些条件下它可能敏感地适应水分和再活性.
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1603-40-3 858431-27-3 866806-96-4物理性质
MSDS等安全信息
合成工艺路线路线简述
海关参考信息
- 2933310010-吡啶
2903110000-一氯甲烷及氯乙烷
2939800000-其他生物碱 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-2009209554-A1
优先权日:2004-03-24
标题 :Thiazoliums as transketolase inhibitors
发明人：BOYD STEVEN A; CONDROSKI KEVIN R; DE MEESE JASON; GONZALES STEPHEN S; GUNAWARDANA INDRANI W; KAPLAN TOMAS; HUEROU YVAN LE; LYSSIKATOS JOSEPH; ROMOFF TODD T; SULLIVAN FRANCIS X; THOMAS ALLEN
权利人:ARRAY BIOPHARMA INC
摘要:The present invention provides N-3′-pyridyl-methyl or N-2′-pyrazinylmethyl thiazolium derivatives of formula (I) which are useful as transketolase inhibitors wherein R 1 , R 2 , R 3 , Y, R 5 -R 9 , R a -R d , n and X − are as defined herein. The present invention also provides pharmaceutical compositions comprising the compounds of formula (I). The invention provides methods for inhibiting transketolase activity, reducing cellular ribose-5-phosphate levels, inhibiting nucleic acid synthesis, inhibiting cell proliferation and tumor cell growth in vitro and in vivo, stimulating apoptosis in tumor cells and treating cancer by administering a compound of formula (I) or a pharmaceutical composition thereof.
