CAS: 80448-90-4; Dynorphin A
- 英文名称Dynorphin A
- 中文名称强啡肽A
- 其它别名Dynorphin A(pig); Dynorphin (1-17); Dynorphin A (human); Dynorphin A (porcine); Dynorphin A (rat); L-Glutamine,L-tyrosylglycylglycyl-L-phenylalanyl-L-leucyl-L-arginyl-L-arginyl-L-isoleucyl-L-arginyl-L-prolyl-L-lysyl-L-leucyl-L-lysyl-L-tryptophyl-L-a-aspartyl-L-asparaginyl-; Porcinedynorphin (1-17); Porcine dynorphin A (1-17); dynorphin-A (Bos taurus)
- CAS编号80448-90-4
- MFCD编号:MFCD00079857
- FDA UNII编号:9M18T0TD14
- 分子式:C99H155N31O23分子量:2147.52
- 产品CID: 1799750
- 产品分类生物化工 → 多肽
物理性质
MSDS等安全信息
- 警示词warning
- 危险描述H303 May be harmful if swallowed+H313 Skin contact may be harmful+H333 Inhalation may be harmful to the body
- 防范说明P264Thoroughly clean after treatmentP280Wear protective gloves/Wear protective clothing/Wear protective goggles/Wear a protective maskP305If it enters the eyesP351Rinse carefully with water for a few minutesP338Remove the contact lens(If any)And easy to operate,Continue flushingP337If eye irritation persistsP313Obtain medical advice/care
- UN编号NONH for all modes of transport
- 安全声明22-24/25
- WGK Germany3
合成工艺路线路线简述
- 71989-16-7 + 105047-45-8 + 119062-05-4 + 91000-69-0 + 29022-11-5 + 71989-23-6 + 92954-90-0 + 71989-20-3 + 35661-60-0 + 35737-15-6 + 71989-31-6 + 35661-40-6 = 80448-90-4
反应条件:1.1 Rt1.2 Reagents: Piperidine Solvents: Dimethylformamide; 20 Min,Rt1.3 Reagents: 1-Hydroxybenzotriazole,Diisopropylethylamine,1-[bis(Dimethylamino)Methylene]-1H-Benzotriazolium Hexafluorophosphate(1-) 3-Oxi... Solvents: Dimethylformamide; 1 H,Rt1.4 Reagents: Piperidine Solvents: Dimethylformamide; 20 Min,Rt1.5 Reagents: 1-Hydroxybenzotriazole,Diisopropylethylamine,1-[bis(Dimethylamino)Methylene]-1H-Benzotriazolium Hexafluorophosphate(1-) 3-Oxi... Solvents: Dimethylformamide; 1 H,Rt1.6 Reagents: Piperidine Solvents: Dimethylformamide; 20 Min,Rt1.7 Reagents: 1-Hydroxybenzotriazole,Diisopropylethylamine,1-[bis(Dimethylamino)Methylene]-1H-Benzotriazolium Hexafluorophosphate(1-) 3-Oxi... Solvents: Dimethylformamide; 1 H,Rt1.8 Reagents: Piperidine Solvents: Dimethylformamide; 20 Min,Rt1.9 Reagents: 1-Hydroxybenzotriazole,Diisopropylethylamine,1-[bis(Dimethylamino)Methylene]-1H-Benzotriazolium Hexafluorophosphate(1-) 3-Oxi... Solvents: Dimethylformamide; 1 H,Rt1.10 Reagents: Piperidine Solvents: Dimethylformamide; 20 Min,Rt1.11 Reagents: 1-Hydroxybenzotriazole,Diisopropylethylamine,1-[bis(Dimethylamino)Methylene]-1H-Benzotriazolium Hexafluorophosphate(1-) 3-Oxi... Solvents: Dimethylformamide; 1 H,Rt1.12 Reagents: Piperidine Solvents: Dimethylformamide; 20 Min,Rt1.13 Reagents: 1-Hydroxybenzotriazole,Diisopropylethylamine,1-[bis(Dimethylamino)Methylene]-1H-Benzotriazolium Hexafluorophosphate(1-) 3-Oxi... Solvents: Dimethylformamide; 1 H,Rt1.14 Reagents: Piperidine Solvents: Dimethylformamide; 20 Min,Rt1.15 Reagents: 1-Hydroxybenzotriazole,Diisopropylethylamine,1-[bis(Dimethylamino)Methylene]-1H-Benzotriazolium Hexafluorophosphate(1-) 3-Oxi... Solvents: Dimethylformamide; 1 H,Rt1.16 Reagents: Piperidine Solvents: Dimethylformamide; 20 Min,Rt1.17 Reagents: 1-Hydroxybenzotriazole,Diisopropylethylamine,1-[bis(Dimethylamino)Methylene]-1H-Benzotriazolium Hexafluorophosphate(1-) 3-Oxi... Solvents: Dimethylformamide; 1 H,Rt1.18 Reagents: Piperidine Solvents: Dimethylformamide; 20 Min,Rt1.19 Reagents: 1-Hydroxybenzotriazole,Diisopropylethylamine,1-[bis(Dimethylamino)Methylene]-1H-Benzotriazolium Hexafluorophosphate(1-) 3-Oxi... Solvents: Dimethylformamide; 1 H,Rt1.20 Reagents: Piperidine Solvents: Dimethylformamide; 20 Min,Rt1.21 Reagents: 1-Hydroxybenzotriazole,Diisopropylethylamine,1-[bis(Dimethylamino)Methylene]-1H-Benzotriazolium Hexafluorophosphate(1-) 3-Oxi... Solvents: Dimethylformamide; 1 H,Rt1.22 Reagents: Piperidine Solvents: Dimethylformamide; 20 Min,Rt1.23 Reagents: 1-Hydroxybenzotriazole,Diisopropylethylamine,1-[bis(Dimethylamino)Methylene]-1H-Benzotriazolium Hexafluorophosphate(1-) 3-Oxi... Solvents: Dimethylformamide; 1 H,Rt1.24 Reagents: Piperidine Solvents: Dimethylformamide; 20 Min,Rt1.25 Reagents: Trifluoroacetic Acid,Triisopropylsilane Solvents: Tetrahydrofuran; 3 H,Rt
标题:Structure-Activity Relationships Of [des-Arg7]Dynorphin A Analogues At The K Opioid Receptor
作者:Ramos-Colon,Cyf N.; Et Al
参考文献:Journal Of Medicinal Chemistry 日期:2016 卷标:59(22) 页码:10291-10298]
132388-59-1 + 143824-78-6 + 29022-11-5 + 71989-38-3 + 71989-14-5 + 132327-80-1 + 71989-23-6 + 154445-77-9 + 71989-26-9 + 35661-60-0 + 71989-31-6 + 35661-40-6 = 80448-90-4
反应条件:1.1 -1.2 Reagents: 4-Methylmorpholine,1-Hydroxybenzotriazole,O-(Benzotriazol-1-Yl)-N,N,N′,N′-Tetramethyluronium Tetrafluoroborate Solvents: Dimethylformamide1.3 Reagents: 4-Methylmorpholine,1-Hydroxybenzotriazole,O-(Benzotriazol-1-Yl)-N,N,N′,N′-Tetramethyluronium Tetrafluoroborate Solvents: Dimethylformamide1.4 Reagents: 4-Methylmorpholine,1-Hydroxybenzotriazole,O-(Benzotriazol-1-Yl)-N,N,N′,N′-Tetramethyluronium Tetrafluoroborate Solvents: Dimethylformamide1.5 Reagents: 4-Methylmorpholine,1-Hydroxybenzotriazole,O-(Benzotriazol-1-Yl)-N,N,N′,N′-Tetramethyluronium Tetrafluoroborate Solvents: Dimethylformamide1.6 Reagents: 4-Methylmorpholine,1-Hydroxybenzotriazole,O-(Benzotriazol-1-Yl)-N,N,N′,N′-Tetramethyluronium Tetrafluoroborate Solvents: Dimethylformamide1.7 Reagents: 4-Methylmorpholine,1-Hydroxybenzotriazole,O-(Benzotriazol-1-Yl)-N,N,N′,N′-Tetramethyluronium Tetrafluoroborate Solvents: Dimethylformamide1.8 Reagents: 4-Methylmorpholine,1-Hydroxybenzotriazole,O-(Benzotriazol-1-Yl)-N,N,N′,N′-Tetramethyluronium Tetrafluoroborate Solvents: Dimethylformamide1.9 Reagents: 4-Methylmorpholine,1-Hydroxybenzotriazole,O-(Benzotriazol-1-Yl)-N,N,N′,N′-Tetramethyluronium Tetrafluoroborate Solvents: Dimethylformamide1.10 Reagents: 4-Methylmorpholine,1-Hydroxybenzotriazole,O-(Benzotriazol-1-Yl)-N,N,N′,N′-Tetramethyluronium Tetrafluoroborate Solvents: Dimethylformamide1.11 Reagents: 4-Methylmorpholine,1-Hydroxybenzotriazole,O-(Benzotriazol-1-Yl)-N,N,N′,N′-Tetramethyluronium Tetrafluoroborate Solvents: Dimethylformamide1.12 Reagents: 4-Methylmorpholine,1-Hydroxybenzotriazole,O-(Benzotriazol-1-Yl)-N,N,N′,N′-Tetramethyluronium Tetrafluoroborate Solvents: Dimethylformamide1.13 Reagents: Trifluoroacetic Acid,Thioanisole,Phenol,1,2-Ethanedithiol Solvents: Trifluoroacetic Acid
标题:Recombinant Cathepsin E Has No Proteolytic Activity At Neutral Ph
作者:Zaidi,Nousheen; Et Al
参考文献:Biochemical And Biophysical Research Communications 日期:2007 卷标:360(1) 页码:51-55
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专利信息
专利号:US-2020354404-A1
优先权日:2019-05-09
标 题 :Peptidomimetic agents, synthesis and uses thereof
发明人：AL-ABED YOUSEF
权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
摘要:Compounds for use in synthesis of peptidomimetic agents; synthesis of peptidomimetic agents; peptidomimetic diagnostic and therapeutic agents; and uses of the compounds and peptidomimetic agents in drug discovery, diagnosis, prevention and treatment of diseases are described.
专利号:US-2008214827-A1
优先权日:2004-02-03
标 题:Synthesis of Cyanoimino-Benzoimidazoles
发明人：GOEHRING R RICHARD; WHITEHEAD JOHN; SHAO BIN
权利人:EURO CELTIQUE SA
摘要:Disclosed in certain embodiments is a process for synthesizing a compound of formula (V) and salts thereof.
专利号:US-10125163-B2
优先权日:2015-10-23
标 题 :Solid phase peptide synthesis
发明人：COLLINS JONATHAN M
权利人:CEM CORP
摘要:An improved method of deprotection in solid phase peptide synthesis is disclosed. In particular the deprotecting composition is added in high concentration and small volume to the mixture of the coupling solution, the growing peptide chain, and any excess activated acid from the preceding coupling cycle, and without any draining step between the coupling step of the previous cycle and the addition of the deprotection composition for the successive cycle. Thereafter, the ambient pressure in the vessel is reduced with a vacuum pull to remove the deprotecting composition without any draining step and without otherwise adversely affecting the remaining materials in the vessel or causing problems in subsequent steps in the SPPS cycle.
专利号:US-6787668-B2
优先权日:2000-04-13
标 题 :2-amino-4,5 heptenoic acid derivatives useful as nitric oxide synthase inhibitors
发明人：PITZELE BARNETT S; SIKORSKI JAMES A; WEBBER RONALD KEITH
权利人:PHARMACIA CORP
摘要:The present invention is directed to a compound of formula I:or a pharmaceutically acceptable salt thereof, wherein:R1 is selected from the group consisting of H and methyl; andR2 is selected from the group consisting of H and methyl.The compounds possess useful nitric oxide synthetase inhibiting activity, and are expected to be useful in the treatment or prophylaxis of a disease or condition in which the synthesis or over synthesis of nitric oxide forms a contributory part.
专利号:WO-2011011384-A9
优先权日:2009-07-20
标 题 :Synthesis of dendrimer conjugates
专利号:US-10919882-B2
优先权日:2019-05-09
标题:Compounds for use in synthesis of peptidomimetics
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📌 第三方产品分析报告
合成参考文献
参考文献:10.1073/pnas.92.15.7006
摘要:Simonin F, Gavériaux-Ruff C, Befort K, Matthes H, Lannes B, Micheletti G, Mattéi MG, Charron G, Bloch B, Kieffer B. kappa-Opioid receptor in humans: cDNA and genomic cloning, chromosomal assignment, functional expression, pharmacology, and expression pattern in the central nervous system. Proc. Natl. Acad. Sci. U.S.A. 1995 Jul 18;92(15):7006–10. doi: 10.1073/pnas.92.15.7006.
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