CAS: 77883-43-3; (4-(4-Amino-6,7-Dimethoxyquinazolin-2-yl)Piperazin-1-yl)(2,3-Dihydrobenzo[b][1,4]Dioxin-2-yl)Methanone Methanesulfonate

(2,3-Dihydrobenzo[b][1,4]Dioxin-2-yl)(1H-Imidazol-1-yl)Methanone 以 四氢呋喃,丙酮 作为反应溶剂,化学反应生成 甲磺酸多沙唑嗪
参考文献:Process For The Preparation Of Doxazosin And Salts Thereof
标题:Process For The Preparation Of Doxazosin And Salts Thereof
摘要:本发明涉及一种制备多沙唑嗪或其盐的方法.

专利信息

专利号:US-10925977-B2
优先权日:2006-10-05
标 题 :Efficient synthesis of chelators for nuclear imaging and radiotherapy: compositions and applications
发明人：YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S
权利人:YANG DAVID J; YU DONGFANG; THOMPSON ANDREW S; CEIL POINT LLC; UNIV TEXAS
摘要:Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.

专利号:WO-9900440-A1
优先权日:1997-06-26
标 题:Synthesis of a dendritic polyalcohol
发明人：IHRE HENRIK; HULT ANDERS
权利人:PERSTORP AB; IHRE HENRIK; HULT ANDERS
摘要:A process for a double stage convergent synthesis of a polymeric polyalcohol substantially and preferably built up from polyester units and composed of a monomeric or polymeric core to which at least one hyperbranched dendritic branch (dendron) consisting of a number of branching generations is added. The branching generations comprise a polymeric or monomeric branching chain extender having three reactive functions of which two are hydroxyl groups and one is a carboxyl group. The two hydroxyl groups of the branching chain extender is in a first step ketal protected by reacting said two hydroxyl groups with a ketal. A second step includes protection of the carboxyl group of said branching chain extender. The ketal protected branching chain extender and the carboxyl protected chain extender are then employed for repeated addition in a number of step yielding a predetermined number of branching generations. The thus synthesized dendron is finally added to a core having reactive hydroxyl or epoxide groups and the ketal protected hydroxyl groups are optionally deprotected.

专利号:US-8481519-B2
优先权日:2005-02-05
标题 :Isolation of atraric acid, synthesis of atraric acid derivatives, and use of atraric acid and the derivatives thereof for the treatment of benign prostatic hyperplasia, prostate carcinoma and spinobulbar muscular atrophy
发明人：HOFFMANN HANS-RAINER; MATUSCH RUDOLF; BANIAHMAD ARIA
权利人:HOFFMANN HANS-RAINER; MATUSCH RUDOLF; BANIAHMAD ARIA; LOHMANN THERAPIE SYST LTS
摘要:A method for isolating atraric acid from biological material, atraric acid derivatives, the chemical synthesis thereof, and the use of atraric acid and the derivatives thereof for treating or producing a medicament for treating benign prostate hyperplasia, prostate carcinoma or spinobulbar muscular atrophy is provided. In addition, a basic substance for the development of other agents used for treating benign prostate hyperplasia, prostate carcinoma, or spinobulbar muscular atrophy is provided.

专利号:US-6211329-B1
优先权日:1997-06-26
标题:Process for preparation of a dendritic polyol
发明人：REHNBERG NICOLA; PETTERSSON BO; ANNBY ULF; MALMBERG MATS
权利人:PERSTORP AB
摘要:A process for synthesis of a polymeric polyalcohol substantially and preferably built up form polyester units and composed of a monomeric or polymeric initiator molecule to which at least one dentritic branch (dendron) consisting of a number of branching generations is added. The branching generations comprise a polymericor monomeric branching chain extender having three reactive functions of which two are hydroxyl groups. The two hydroxyl groups of the ranching chain extender is acetal protected by reaction between said two hydroxyl groups and an acetal-forming carbonyl compound, preferably an aldehyde. The acetal protected branching chain extender is then employed for addition to the initiator molecule of a first branching generation followed by an optional deprotection of the hydroxyl groups by decomposition of acetals and for addition in repeated steps of further branching generations. Additions of branching generations individually employ an acetal protected branching chain extender synthesized from the same or a different branching chain extender and/or acetal-forming carbonyl compound and addition of a branching generation is optionally followed by addition of a spacing generation.

专利号:WO-2005054219-A1
优先权日:2003-12-05
标 题:Process to modify non glycidyl functional impurities of glycidyl esters to be used in further radical polymerisation
发明人：HEYMANS DENIS MARIE CHARLES; HENRY NATHALIE SOLANGE JEANNE; UYTTERHOEVEN GRIET
权利人:RESOLUTION RES BELGIUM S A; HEYMANS DENIS MARIE CHARLES; HENRY NATHALIE SOLANGE JEANNE; UYTTERHOEVEN GRIET
摘要:The present invention relates to a process to modify the non glycidyl functional products occurring in industrially produced glycidyl esters, which are currently used in the synthesis of radical polymerisable acrylic or methacrylic acid derivatives, to be further reacted too resins for coating applications. The process to modify non glycidyl functional impurities in glycidyl esters of branched alkane carboxylic acids, by reacting the fraction of non-glycidyl functional products with ethylenically unsaturated anhydride. Another aspect of the present invention is formed by the cured coating films derived from the hereinbefore defined coating compositions and applied an a shaped substrate, and more in particular an automotives.

专利号:WO-2009115221-A1
优先权日:2008-03-18
标题:Composition for low colour of unsaturated glycidyl esters derivatives and the use thereof
发明人：HEYMANS DENIS MARIE CHARLES; UYTTERHOEVEN GRIET
权利人:HEXION SPECIALTY CHEMICALS RES; HEXION SPECIALTY CHEMICALS INC; HEYMANS DENIS MARIE CHARLES; UYTTERHOEVEN GRIET
摘要:The present invention relates to a composition comprising an aliphatic branched alcohol and glycidyl functional product esters, which are currently used in the synthesis of radical polymerisable acrylic or methacrylic acid derivatives, to be further reacted into resins for coating applications. Another aspect of the present invention is formed by the cured coating films derived from the hereinbefore defined coating compositions and applied on a shaped substrate, and more in particular on automotives.