CAS: 704-38-1; Di(Thiophen-2-yl)Methanone

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CAS号188290-36-0 Thiophene(SIV) | CAS号5271-67-0 2-噻吩甲酰氯 | CAS号201230-82-2 carbon monoxide | CAS号53034-24-5 [diacetyloxy(th... | CAS号5857-39-6 chloro(thiophen... | CAS号45438-82-2 thiophen-2-ylzi... | CAS号3437-95-4 2-碘噻吩 | CAS号609-08-5 甲基丙二酸二乙酯 | CAS号54663-78-4 2-三丁基甲锡烷基噻吩 | CAS号4341-34-8 二(噻吩-2-基)甲烷 | CAS号10558-44-8 双(2-噻吩)甲肟 | CAS号30782-41-3 2-(1-thiophen-2... | CAS号35250-77-2 5-(2-Thenyl)-2-... | CAS号23975-15-7 1,2-二(噻吩-2-基)炔 | CAS号6973-84-8 2-Thiophenemeth... | CAS号62032-07-9 5,5-二噻吩基-2-咪唑烷-...

专利信息

专利号:US-6147226-A
优先权日:1999-02-16
标题 :Synthesis of cyclopentyl 2-thienyl ketone, tiletamine and tiletamine acid addition salts, such as tiletamine hydrochloride
发明人：LAPIN YURI ALEKSANDROVICH; SANCHEZ IGNACIO H
权利人:GREAT LAKES CHEMICAL CORP
摘要:A water-scavenging solvent, such a polyphosphoric acid, can be used for the synthesis of cyclopentyl 2-thienyl ketone by the direct acylation of cyclopentanecarboxylic acid without first reacting the cyclopentanecarboxylic acid with thionylchloride to form the acid chloride, while achieving new and unexpected yields. A tiletamine-free base can be made from the cyclopentyl 2-thienyl ketone with a halide in the presence of a solvent for the cyclopentyl 2-thienyl ketone to form a halogenated cyclopentane 2-thienyl ketone, aminating the halogenated cyclopentane 2-thienyl ketone by reaction with an amine, and subjecting the reaction product to thermal rearrangement, in a suitable solvent, and at a sufficient temperature to form tiletamine free base. Each step for the formation of tiletamine free base can be accomplished using the same solvent, e.g., dichlorobenzene so that intermediates need not be isolated between reactions.

专利号:US-5969159-A
优先权日:1999-02-16
标 题 :Synthesis of cyclopentyl 2-thienyl ketone tiletamine and tiletamine acid addition salts such as tiletamine hydrochloride
发明人：LAPIN YURI ALEKSANDROVICH; SANCHEZ IGNACIO H
权利人:GREAT LAKES CHEMICAL CORP
摘要:Solid, non-tin-containing catalysts can be used for the synthesis of cyclopentyl 2-thienyl ketone by the reaction of cyclopentanecarboxylic acid chloride and thiophene, while achieving new and unexpected yields. Aluminum trichloride is both cheaper than stannic chloride and it is easier to deal with as a waste stream. The successful use of graphite as a catalyst for the reaction of cyclopentanecarboxylic acid chloride and thiophene provides a mild and ecologically friendly method for carrying out the Friedel-Crafts reaction. A tiletamine-free base can be made from the cyclopentyl 2-thienyl ketone with a halide in the presence of a solvent for the cyclopentyl 2-thienyl ketone to form a halogenated cyclopentane 2-thienyl ketone; aminating the halogenated cyclopentane 2-thienyl ketone by reaction with an amine; and subjecting the reaction product to thermal rearrangement, in a suitable solvent, and at a sufficient temperature to form tiletamine free base. Each step for the formation of tiletamine free base can be accomplished using the same solvent, e.g., dichlorobenzene so that intermediates need not be isolated between reactions.

专利号:CZ-2012226-A3
优先权日:2012-03-30
标 题:Process for preparing di- (2-thienyl) glycolic acid scopine ester intermediate in the synthesis of tiotropium bromide

专利号:CZ-305012-B6
优先权日:2012-03-30
标题 :Process for preparing di (2-thienyl) glycolic acid scopine ester intermediate in the synthesis of tiotropium bromide

专利号:CN-109020994-A
优先权日:2017-06-12
标题 :A kind of benzothiophene spirooxindole derivative and its synthesis method and application

专利号:CN-105017209-B
优先权日:2015-07-07
标题:A kind of multi-substituted dihydrothiophene-3-ketone compound and its synthesis method