CAS: 67764-52-7; P,P-Diphenyl-N-(Phenylmethylene)Phosphinic Amide

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diphenylphosphinamide benzaldehyde chloro-diphenylphosphine Benzaldoxime1-Diphenylphosphinylamino-1-phenyl-methanthiophosphonsaeure-O,O-diethylester N-(Benzyl-α-d)-diphenylphosphinamide 3-Diphenylphosphinylamino-3-phenyl-propionsaeuremethylester (RS)-N-(1-phenylethyl)-P,P-diphenylphosphinamide

合成工艺路线路线简述

    📜N-[α-(4-甲基苯基)磺酰基)苄基]二苯基次膦酸酰胺置于potassium Carbonate体系中,用 乙腈 作为反应溶剂,化学反应 12.0H,以91%的收率获得产物n-亚苄基-P,P-二苯基次膦酸酰胺
    参考文献:Preparation Of Enantiomerically Enriched (1S)-1-Phenylpropan-1-Amine Hydrochloride By A Catalytic Addition Of Diorganozinc Reagents To Imines
    标题:Preparation Of Enantiomerically Enriched (1S)-1-Phenylpropan-1-Amine Hydrochloride By A Catalytic Addition Of Diorganozinc Reagents To Imines
    摘要:
    DOI:10.15227/orgsyn.083.0005

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    专利信息


    专利号:US-9328061-B2
    优先权日:2012-03-01
    标题:Simple organic molecules as catalysts for practical and efficient enantioselective synthesis of amines and alcohols
    发明人:HOVEYDA AMIR H; SILVERIO DANIEL L; PILYUGINA TATIANA; TORKER SEBASTIAN; ROBBINS DANIEL
    权利人:TRUSTEES BOSTON COLLEGE
    摘要:The present invention provides organic molecules and methods thereof for reactions between organoboron reagents and double bonds, such as imines or carbonyls, to stereoselectively provide chiral products including amines and alcohols, entities useful for the preparation of biologically active molecules.

    专利号:US-2015057451-A1
    优先权日:2012-03-01
    标 题 :Simple organic molecules as catalysts for practical and efficient enantioselective synthesis of amines and alcohols

    专利号:WO-2013131043-A1
    优先权日:2012-03-01
    标 题:Simple organic molecules as catalysts for practical and efficient enantioselective synthesis of amines and alcohols

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    ✅ COA系统入驻 | 共享模式

    合成参考文献


    参考文献:10.1002/chem.200305418
    摘要:Zhang H, Jiang F, Zhang X, Cui X, Gong L, Mi A, Jiang Y, Wu Y. Modification of (1R,2S)‐1,2‐Diphenyl‐2‐aminoethanol for the Highly Enantioselective, Asymmetric Alkylation of N‐Diphenylphosphinoyl Arylimines with Dialkylzinc. Chemistry A European J. 2004 Mar 15;10(6):1481–92. doi: 10.1002/chem.200305418.
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