CAS: 67648-61-7; 2-(4-Hydroxyphenoxy)Propanoic Acid

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CAS号65343-67-1 2-(4-羟基苯氧基)丙酸乙酯 | CAS号69033-92-7 Propanoic acid,... | CAS号1634-04-4 甲基叔丁基醚 | CAS号103-16-2 莫诺苯宗 | CAS号63650-08-8 2-(4-苄氧基苯氧基)丙酸乙酯 | CAS号37067-27-9 对苯二酚一硫酸钾 | CAS号108-95-2 苯酚 | CAS号13794-15-5 2-(4-甲氧基苯氧基)丙酸 | CAS号105118-15-8 (S)-2-(4-hydrox... | CAS号94050-90-5 (R)-(+)-2-(4-羟基... | CAS号95977-29-0 氟吡禾灵 | CAS号65343-67-1 2-(4-羟基苯氧基)丙酸乙酯 | CAS号99761-32-7 2-(4-乙氧基-苯氧基)-丙酸 | CAS号60074-23-9 2-[4-(5-chlorop...

📜4-苄氧基苯酚置于palladium On Activated Charcoal 氢氧化钾,氢气,Sodium Hydride体系中,用 四氢呋喃,乙醇,水 作为反应溶剂,化学反应 23.0H,反应生成 2-(4-羟基苯氧基)丙酸
参考文献:微生物对α-取代的羧酸的脱硝作用:底物特异性和机理研究.
标题:微生物对α-取代的羧酸的脱硝作用:底物特异性和机理研究.
摘要:报道了一种用于制备旋光的α-取代的羧酸的新的酶促方法.这项技术称为脱硝反应,它为我们提供了从外消旋混合物开始,理论上以100%的收率获得对映体纯化合物的途径.这意示外消旋体的合成几乎与旋光化合物的合成相同,并且该概念与不对称合成中通常被接受的概念完全不同.使用不断增长的诺卡氏夜蛾诺卡氏菌jcm3208的细胞系统,可以使2-芳基-和2-芳基氧基丙酸的外消旋物顺利脱硫,并以高化学收率(> 50%)回收富含(R)-形式的产物.此外,使用旋光性起始化合物和氘代衍生物以及抑制剂,
DOI:10.1021/jo034253X

专利信息

专利号:US-4837355-A
优先权日:1980-08-21
标 题:Process for the synthesis of phenoxyalkane derivatives
发明人：WATSON KEITH G
权利人:ICI AUSTRALIA LTD
摘要:The invention concerns a process for the synthesis of a compound of formula I ##STR1## wherein: U and V may be chosen from a range of substituents including hydrogen, halogen, alkyl and alkoxy; R 1 and R 2 may be chosen from a range of substituents including hydrogen and alkyl; n is 0, 1 or 2; and W may be chosen from a range of substitutents including the group ##STR2## which may be a free carboxylic acid or derivative thereof; the process comprising reacting a sulfate ester of formula II, wherein Q is a cation, with a compound of formula III, wherein L is a leaving group ##STR3## and hydrolyzing the sulfate ester formed. Preferably the sulfate ester of formula II is prepared by the oxidation of a phenol of formula IV with a persulfate. ##STR4##

专利号:US-6235899-B1
优先权日:1997-07-15
标 题 :Method for preparing alkyloxy furanone derivatives, compounds obtained by said method and use of said compounds
发明人：BOUCHET RAPHAEL; BRION FRANCIS; COLLADANT COLETTE; LAGOUARDAT JACQUES
权利人:HOECHST MARION ROUSSEL INC
摘要:The invention relates to a novel process for preparing compounds of the formula (IV) or (I):from the racemic alkoxyfuranone of the formula (II):R1 and R2 being as defined in the description, to the novel compounds of the formula (IV) as well as to the intermediate compounds of this process, and to the use of the compounds of the formula (IV) or (I) in the process for the synthesis of compounds which inhibit interleukin-1beta converting enzyme.

专利号:WO-2011158257-A1
优先权日:2010-06-18
标题 :Preparation process of fesoterodine and intermediates
发明人：JAIN RAJESH; RAO SIRIPRAGADA MAHENDER; RAO JAGADEESHWAR R; MADADA CHANDRA RAO
权利人:PANACEA BIOTEC LTD; JAIN RAJESH; RAO SIRIPRAGADA MAHENDER; RAO JAGADEESHWAR R; MADADA CHANDRA RAO
摘要:The present invention relates to a process of synthesis of 3,3 dipheylpropylamines, which may be used as pharmaceutical intermediates in the preparation of their pharmacologically active derivatives such as fesoterodine, tolterodine, their enantiomers, pharmaceutically acceptable salts and related compounds useful as antimuscarinic agents.

专利号:US-2005192265-A1
优先权日:2003-03-20
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THOMPSON RICHARD C; WILKIE STEPHEN; STACK DOUGLAS R; VANMETER ELDON E; SHI QING; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; HENRY STEVEN S; MCDANIEL STACEY L; STUCKY RUSSELL D; PORTER WARREN J
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-6906056-B2
优先权日:1998-06-22
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THOMPSON RICHARD C; WILKIE STEPHEN; STACK DOUGLAS R; VANMETER ELDON E; SHI QING; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; HENRY STEVEN S; MCDANIEL STACEY L; STUCKY RUSSELL D; PORTER WARREN J
权利人:LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-6531470-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.