CAS: 619-45-4; Methyl 4-Aminobenzoate

上下游产品

CAS号67-56-1 甲醇 | CAS号150-13-0 对氨基苯甲酸 | CAS号1126-46-1 甲基-4-氯苯甲酸甲酯 | CAS号106896-49-5 4-氨基-3-溴苯甲酸甲酯 | CAS号619-42-1 对溴苯甲酸甲酯 | CAS号619-50-1 4-硝基苯甲酸甲酯 | CAS号20442-96-0 Methyl 4-azidob... | CAS号99768-12-4 4-甲酯基苯硼酸 | CAS号1147543-77-8 2-(4-methoxycar... | CAS号18144-47-3 4-氨基苯甲酸叔丁酯 | CAS号108871-76-7 methyl 4-(2-met... | CAS号107920-79-6 4-苯磺酰氨基苯甲酸甲酯 | CAS号107233-58-9 Methyl 4-[(cyan... | CAS号555-06-6 对氨基苯甲酸钠 | CAS号36729-27-8 6,7,8,9-四氢-5H-咔... | CAS号54472-45-6 4-氨基苯甲酰胺基乙醇 | CAS号14266-19-4 methyl 3,5-diio... | CAS号41727-48-4 4-氨基-3,5-二氯苯甲酸甲酯 | CAS号3662-78-0 4-甲氧基羰酰基苯基硫氰酸酯 | CAS号17595-86-7 4-噻吩-2-硼酸甲酯

对氯苯甲酸甲酯置于potassium Phosphate,双(三-O-甲苯磷)钯(0),(R)-(-)-1-[(S)-2-(Dicyclohexylphosphino)Ferrocenyl]Ethyl-Di-Tert-Butylphosphine,氨体系中,用 1,4-二氧六环 作为反应溶剂,70.0 °C,551.59 Kpa 条件下,反应 12.0H,以79%的收率获得产物4-氨基苯甲酸甲酯
参考文献:氨与芳基氯化物,溴化物,碘化物和磺酸盐的钯催化偶联:制备伯芳胺的一般方法
标题:氨与芳基氯化物,溴化物,碘化物和磺酸盐的钯催化偶联:制备伯芳胺的一般方法
摘要:我们报告说,由 Pd[p(O-Tol)(3)](2) 和烷基双膦 Cypf-T-Bu 反应生成的复合物是一种高活性和选择性的催化剂,用于将氨与芳基氯化物,溴化物,碘化物,和磺酸盐.用氨在二恶烷中的溶液进行的氨与该催化剂的偶联以高产率从各种芳基亲电试剂形成伯芳基胺.低至 0.1 Mol% 的催化剂负载量足以进行许多芳基氯化物和溴化物的反应.在这种催化剂的存在下,芳基磺酸盐也首次以高产率与氨偶联.将这种催化剂存在下的反应与现有铜和钯系统存在下的反应进行比较,揭示了互补的底物范围,如果不是更广泛的话.该方法用于反应生成酰胺,酰亚胺,和氨基甲酸酯通过从芳基溴化物和氯化物,氨和酰基氯或酸酐一锅合成这些羰基化合物的小库来说明.机理研究表明,与使用 Cypf-T-Bu 和钯 (II) 作为催化剂前体,因为钯 (II),氨和碱的组合产生的活性催化剂浓度低.
DOI:10.1021/ja903049Z

专利信息

专利号:WO-2021260722-A1
优先权日:2020-06-21
标 题:Design, synthesis of novel oxyindole inhibitors of denv rna dependent rna polymerase
发明人：GUNDLA RAMBABU; ASTHANA SHAILENDRA; BHATTACHARYYA SANKAR; MADDIPATI VENKATANARAYANA CHOWDARY; MITTAL LOVIKA; KAUR JASKARAN; RAWAT YOGITA
权利人:TRANSLATIONAL HEALTH SCIENCE AND TECH INSTITUTE; GANDHI INSTITUTE OF TECH AND MANAGEMENT
摘要:The present invention is drawn to novel compounds of formula I, II and III, including any conformational isomeric form, salts and solvates for inhibition of DENV RNA dependent and RNA polymerase. The present invention also discloses a process of synthesis of the compounds, compositions comprising the said compounds and use of the compounds and treatment comprising the compounds of the present invention.

专利号:US-8809526-B2
优先权日:2010-07-19
标题 :Synthesis of cyclopentaquinazolines
发明人：KERSCHEN JAMES ALAN; BRIDGES ALEXANDER JAMES; DALZIEL SEAN MARK; DAPREMONT Olivier; KIM HYUNJUNG; THOMPSON ANDREW S; ZELLER JAMES ROBERT
权利人:KERSCHEN JAMES ALAN; BRIDGES ALEXANDER JAMES; DALZIEL SEAN MARK; DAPREMONT Olivier; KIM HYUNJUNG; THOMPSON ANDREW S; ZELLER JAMES ROBERT; ONYX PHARMA INC
摘要:A method of producing 6-amino-cyclopenta[g]quinazolines, in enantiomerically enriched form, is provided. In particular, the method may be applicable to the synthesis of N—{N-{4-[N-((6S)-2 -hydroxymethyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclo-penta[g]quinazolin-6-yl)-N-(prop-2 -ynyl)amino]benzoyl}-L-γ-glutamyl}-D-glutamic acid (ONX-0801).

专利号:US-10005720-B2
优先权日:2013-04-05
标题:Compounds useful for the treatment of metabolic disorders and synthesis of the same
发明人：SEXTON JONATHAN Z; BRENMAN JAY E; MUSSO DAVID L
权利人:NORTH CAROLINA CENTRAL UNIV; UNIV NORTH CAROLINA CHAPEL HILL
摘要:The present invention provides compounds of Formula (I): wherein variables X, Y, Z and R1 are as described herein. Some of the compounds described herein are glutamate dehydrogenase activators. The invention is also directed to pharmaceutical compositions comprising these compounds, uses of these compounds and compositions in the treatment of metabolic disorders as well as synthesis of the compounds.

专利号:EP-1641729-B1
优先权日:2003-07-09
标题:Use of functionalized onium salts as a soluble support for organic synthesis
发明人：VAULTIER MICHEL; GMOUH SAID; HASSINE FATIMA
权利人:CENTRE NAT RECH SCIENT; UNIV RENNES
摘要:The invention relates to the use of a onium salt functionalized by at least one organic function, as a soluble support, in the presence of at least one organic solvent, for organic synthesis of a molecule, in a homogenous phase, by at least one transformation of said organic function. The onium salt enables the synthesized molecule to be released. The onium salt is present in liquid or solid form at room temperature and corresponds to formula A₁⁺, X₁^-, wherein A₁⁺ represents a cation and X₁^- represents an anion.

专利号:US-2012196989-A1
优先权日:2005-02-11
标题:Synthesis of homopolymers and block copolymers
发明人：BREITENKAMP KURT; SILL KEVIN N
权利人:BREITENKAMP KURT; SILL KEVIN N; INTEZYNE TECHNOLOGIES INC
摘要:The present invention relates to the field of polymer chemistry and more particularly to homopolymers and block copolymers and methods of preparing the same.

专利号:US-4897484-A
优先权日:1986-12-19
标题 :Process for the preparation of substituted pyridines
发明人：WEIS CLAUS D; SUTTER PETER
权利人:CIBA GEIGY CORP
摘要:A process is described for the preparation of compounds of the formula (1) in which R and X are as defined in claim 1. The compounds of the formula (1) are valuable intermediates in the synthesis of triarylmethane dyes and triarylmethanelactones.