CAS: 61367-62-2; 4-Bromo-3,5-Dimethoxybenzyl Alcohol

上下游产品

methyl 4-bromo-3,5-dimethoxybenzoate 3,5-dimethoxybenzyl alcohol 4-bromo-3,5-dimethoxybenzoic acid 3,5-dihydroxy-4-bromobenzoic acid 4-bromo-3,5-dimethoxybenzyl chloride 2-bromo-1,3-dimethoxy-5-[(1,1-dimethylethyl)diphenylsilyloxymethyl]benzene 1-[(4-bromo-3,5-dimethoxybenzyl)oxy]tetrahydro-2H-pyran tert-butyl-dimethyl-silanyloxymethyl)-2,6-dimethoxy-phenyl]-2-(2-methyl-[1,3]dioxolan-2-yl)-ethanol1-[4-(tert-butyl-dimethyl-silanyloxymethyl)-2,6-dimethoxy-phenyl]-2-(2-methyl-[1,3]dioxolan-2-yl)-ethanol

3,5-二羟基苯甲酸置于盐酸,Lithium Aluminium Tetrahydride,溴,Potassium Carbonate体系中,用 四氢呋喃,水,丙酮 作为反应溶剂,化学反应 6.5H,反应生成 4-溴-3,5-二甲氧基苯甲醇
参考文献:山慈姑星c和bletistrin G的木化合成及生物学评价
标题:山慈姑星c和bletistrin G的木化合成及生物学评价
摘要:从兰花中分离出的天然产物 Shancigusin C (1) 和 Bletistrin G (2) 的生物活性及其首次全合成已被报道. Shancigusin C (1) 的全合成是通过 Perkin 反应形成中心二苯乙烯核进行的,而 Bletistrin G (2) 的合成是通过 Wittig 烯化和几个区域选择性芳香族取代反应来实现的.两种合成都是根据木糖化学原理仅使用可再生原材料来完成的. Shancigusin C (1) 和 Bletistrin G (2) 对抗肿瘤细胞的细胞毒性特性表明适合作为进一步结构变异的起点.
DOI:10.3390/molecules26113224

专利信息

专利号:US-7858809-B2
优先权日:2004-04-12
标题 :Process for production of pyrazole-fused ring derivatives
发明人：NEGI SHIGETO; SHIMIZU TOSHIKAZU; KURODA HIROSHI; SHIMOMURA NAOYUKI; SASHO MANABU; HOSHINO YORIHISA; KUBOTO MANABU
权利人:EISAI R&D MAN CO LTD
摘要:Intermediates useful for the synthesis of pyrazole-fused ring derivatives, such as 7-phenylpyrazolo [1,5-a]pyridine derivatives, and method for producing the same. Method for producing compound represented by the general formula (II), wherein Z 1 and Z 2 each independently represents a methine group or a nitrogen atom; R l represents an ethyl group or the like; R 5 represents a hydrogen atom or the like; R 2 and R 3 each independently represents a C 1-6 alkyl group or the like, salts thereof, or solvates of both, comprising the step of: reacting a compound represented by the general formula (I), wherein Z 1 , Z 2 , R 5 , R 1 , R 2 and R 3 each has the same definition as described above, with an organometallic reagent; and then reacting the resulting product with pentafluoroiodobenzene.