CAS: 5959-52-4; 3-Amino-2-Naphthoic Acid

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CAS号92-70-6 2-羟基-3-萘甲酸 | CAS号5810-96-8 1H-benzo[f]indo... | CAS号91-59-8 2-萘胺 | CAS号5580-64-3 Acetamide,2-(hy... | CAS号10546-24-4 3-甲基-2-萘胺 | CAS号104877-13-6 2-Naphthaleneca... | CAS号110571-73-8 2-phenylbenzo[g... | CAS号532-18-3 2,2-二萘胺 | CAS号100171-44-6 7H-dibenz[a,i]a... | CAS号92-70-6 2-羟基-3-萘甲酸 | CAS号21815-18-9 N-苯基-2,3-萘二甲酰亚胺基 | CAS号21597-54-6 3-Aminonaphthal... | CAS号29005-25-2 2-cyanoindene | CAS号91-59-8 2-萘胺

📜2-羟基-3-萘甲酸置于ammonium Hydroxide,Zinc(II) Chloride体系中,用 水 作为反应溶剂,化学反应 108.0H,以60%的收率获得产物3-氨基-2-萘甲酸
参考文献:一种新型的克罗霉素/多卡霉素混合天然产物的合成和生物学评价
标题:一种新型的克罗霉素/多卡霉素混合天然产物的合成和生物学评价
摘要:实验方法:所有空气敏感反应均在氩气气氛下在火焰干燥烧瓶中进行,反应物通过注射器或转移套管引入.所有溶剂均通过标准方法干燥,从商业来源获得的试剂无需进一步纯化即可使用.在预涂硅胶板(tlc硅胶60 F254,Merck)上进行薄层色谱.硅胶 60 (0.032-0.064 Mm,Merck) 用于柱层析.使用 Biotage 的 Isoleratm One 快速纯化系统和预装硅胶柱 (Snap 10,25,50,100 G) 进行快速柱层析.
DOI:10.3987/com-12-S(N)37

专利信息

专利号:US-9206222-B2
优先权日:2009-06-29
标题:Solid phase peptide synthesis of peptide alcohols
发明人：CAUSSIL-AMBLARD MURIEL; MARTINEZ JEAN; TAILHADES JULIEN
权利人:CAUSSIL-AMBLARD MURIEL; MARTINEZ JEAN; TAILHADES JULIEN; CENTRE NAT RECH SCIENT
摘要:The present invention relates to the synthesis of depsipeptides on solid phase support. Said depsipeptides are then implicated in a solution phase O—N acyl shift enabling to obtain the corresponding peptide alcohols.

专利号:US-6051704-A
优先权日:1996-07-22
标题:Synthesis of macrocyclic tetraamido-N ligands
发明人：GORDON-WYLIE SCOTT W; COLLINS TERRENCE J
权利人:UNIV CARNEGIE MELLON
摘要:New synthetic methods for the preparation of macrocyclic amido-N donor ligands are provided. The primary method of the present invention involves in general only two synthetic steps. In the first step, an α or β amino carboxylic acid is allowed to react with an optimal (approximately stoichiometric) amount of an activated malonate or oxalate derivative with mild heating. Upon completion of the double coupling reaction, hydrolysis of the reaction mixture yields a diamide containing intermediate (a macro linker). In the second step, stoichiometric amounts of a diamine, preferably an orthophenylene diamine, are added to the macro linker intermediate in the presence of a coupling agent and heat. This second double coupling reaction, is allowed to proceed for a period of time sufficient to produce a macrocyclic tetraamido compound. The substituent groups on the α or β amino carboxylic acid, the malonate, and the aryl diamine may all be selectively varied so that the resulting tetraamido macrocycle can be tailored to specific desired end uses. The macrocyclic tetraamide ligand may then be complexed with a metal, such as a transition metal, and preferably the middle and later transition metals, to form a robust chelate complex suitable for catalyzing oxidation reactions.

专利号:US-5783577-A
优先权日:1995-09-15
标题 :Synthesis of quinazolinone libraries and derivatives thereof
发明人：HOUGHTEN RICHARD A; OSTRESH JOHN M
权利人:TREGA BIOSCIENCES INC
摘要:The present invention provides synthetic combinatorial libraries of organic compounds based on the quinazolinone ring.

专利号:US-7060818-B2
优先权日:2003-02-21
标题:Synthesis of macrocyclic tetraamido compounds and new metal insertion process
发明人：HORWITZ COLIN P; GHOSH ANINDYA
权利人:UNIV CARNEGIE MELLON
摘要:An improved method of synthesizing a macrocyclic tetraamido compound includes protecting the amino portion of an amino carboxylic acid to form a protected amino carboxylic acid; exposing the protected amino carboxylic acid to a first solvent, preferably a hydrocarbon solvent, such as toluene or 1,2-dichloroethane, dichloromethane, dibromomethane and 1,2-dibromoethane. The carboxylic acid portion of the protected amino carboxylic acid is then converted to an activated carboxylic acid by one of esterification or acid halide formation, to form a protected amino activated carboxylic acid derivative. The protected amino activated carboxylic acid derivative is reacted with a diamine in the presence of a second solvent, such as THF or ,2-dichloroethane, dichloromethane, dibromomethane and 1,2-dibromoethane, to form a protected diamide diamine intermediate. Following deprotection, the diamide diamine intermediate is reacted with an activated diacid, such as an activated malonate, oxalate or succinate derivative to form the macrocyclic tetraamido compound. The macrocyclic tetraamido compound may further be complexed with a transition metal.

专利号:US-2023364251-A1
优先权日:2020-08-06
标 题:Methods for the synthesis of protein-drug conjugates
发明人：BORCHARDT ALLEN; HUGHES ROBERT MICHAEL
权利人:CIDARA THERAPEUTICS INC
摘要:The present invention relates to intermediates and methods for synthesizing protein-drug conjugates that can be used for the treatment of diseases and related conditions.

专利号:US-7365197-B2
优先权日:2000-12-29
标题 :Method for the regioselective preparation of substituted benzo[g]quinoline-3-carbonitriles and benzo[g]quinazolines
发明人：BERGER DAN MAARTEN; BIRNBERG GARY HAROLD; WANG YANONG
权利人:WYETH CORP
摘要:This invention relates to a method for the regioselective synthesis of 4,6,7,8-substituted benzo[g]quinoline-3-carbonitriles and 4,6,7,8-substituted benzo[g]quinazolines as well as intermediates thereof. The compounds derived from this invention are useful for the treatment of a variety of diseases that are a result of deregulation of these PTK's, and more specifically, are anti-cancer agents and are useful for the treatment of cancer in mammals. In addition, the compounds derived from this invention are useful for the treatment of polycystic kidney disease in mammals.