欧盟法规
ECHA物质ECHA物质C&L通报REACH预注册专利信息
专利号:US-9914695-B2
优先权日:2015-07-10
标题:Two-step process for preparing 3-substituted phenylalkylamines
发明人:Teramura Doug; LIAO SUBO
权利人:MALLINCKRODT LLC
摘要:Processes for preparing 3-substituted phenylalkylamines comprising reacting a phenyl boronic compound with an α-β unsaturated carbonyl-containing compound via an asymmetric 1,4-addition reaction, followed by reductive alkylation. The processes may be useful in the synthesis of tapentadol.
专利号:US-9556108-B2
优先权日:2014-07-10
标题 :Process for preparing substituted phenylalkanes
发明人:LIAO SUBO; MCCLURG JOSEPH; TRAWICK BOBBY
权利人:MALLINCKRODT LLC
摘要:The invention provides methods for preparing substituted phenylalkanes. In particular, the processes comprise reacting a phenyl boronic compound with an α-β unsaturated carbonyl-containing compound via an asymmetric 1,4-addition reaction. The processes may be useful in the synthesis of tapentadol.